ID A0A8M9PIB5_DANRE Unreviewed; 1638 AA. AC A0A8M9PIB5; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 08-NOV-2023, entry version 8. DE SubName: Full=Neurexin 2a isoform X8 {ECO:0000313|RefSeq:XP_021324529.1}; GN Name=nrxn2a {ECO:0000313|RefSeq:XP_021324529.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_021324529.1}; RN [1] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|RefSeq:XP_021324529.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021324529.1}; RG RefSeq; RL Submitted (JUL-2023) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_021324529.1; XM_021468854.1. DR Proteomes; UP000000437; Chromosome 21. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt. DR CDD; cd00054; EGF_CA; 2. DR CDD; cd00110; LamG; 6. DR Gene3D; 2.60.120.200; -; 6. DR Gene3D; 2.10.25.10; Laminin; 3. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR003585; Neurexin-like. DR PANTHER; PTHR15036:SF89; NEUREXIN 1, ISOFORM F; 1. DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1. DR Pfam; PF02210; Laminin_G_2; 6. DR SMART; SM00294; 4.1m; 1. DR SMART; SM00181; EGF; 3. DR SMART; SM00282; LamG; 6. DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6. DR PROSITE; PS50026; EGF_3; 3. DR PROSITE; PS50025; LAM_G_DOMAIN; 6. PE 4: Predicted; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..28 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 29..1638 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5035439513" FT TRANSMEM 1563..1583 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 28..204 FT /note="Laminin G" FT /evidence="ECO:0000259|PROSITE:PS50025" FT DOMAIN 200..238 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 280..478 FT /note="Laminin G" FT /evidence="ECO:0000259|PROSITE:PS50025" FT DOMAIN 485..673 FT /note="Laminin G" FT /evidence="ECO:0000259|PROSITE:PS50025" FT DOMAIN 677..714 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 717..891 FT /note="Laminin G" FT /evidence="ECO:0000259|PROSITE:PS50025" FT DOMAIN 905..1080 FT /note="Laminin G" FT /evidence="ECO:0000259|PROSITE:PS50025" FT DOMAIN 1084..1121 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1125..1295 FT /note="Laminin G" FT /evidence="ECO:0000259|PROSITE:PS50025" FT REGION 1445..1504 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1593..1638 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1594..1625 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1638 AA; 178320 MW; 4664791C7BC81A0A CRC64; MMTRKWRCVK LSPAFVWLGL VVLSVTTALE FDGLPGQWVR YGPWEAGATG ELSFTMKTNI SKAIVLYLDD GGNCDFLELL INDGRLQLRF AIHCGEPASL HMETHISDER WHRVLLTRNY RETMLVMDGE SKVAEVKSKR REMMVASDLY VGGIPPDVRL SALTSSTVKY EPPFRGLIAN LKLGETAPAL LDSQGVKNDL DYLCTKQNPC SNGGRCSIQG SEVLCDCSNT GYKGKYCTEV LQQVLGGLAH LTLKSQAPGA APLMATPAAG DPKSGQVESV ATFKGNEFFS YDLSQKPIQS STDEITLSFR TLQRNGLLLH TGKSADYVNL SLKSGAVCLV INLGSGAFEA LVEPSDGKFN DNAWHAVRVS RNLRQRAGVG LPTVNKLHYM QVTISVDGLL TTTGYTQEDY TMLGSDDFFY VGGSPNTADL PGSPVSNNFM GCLKDVVYTN NEFRLELSHL AELRDPKVTL HGDLTFRCED VAALDPVSFD APTAYVTLPR WNGKKAGSVS FDFRTTEPNG LLLFSHGRPQ GSKDHRPRVD FFAMELLDGF LHLLMDMGSG SIKIKVGNKK VNDGEWCHVD FQREGRKGSI SVNGRSLPFS TNEGSEILDL DGEMYLGGLP ENSGDLSLPP EVWTARLRLG FVGCVRDLFV DGRSKDLRRL AELQSAPGVS SFCTRETHRR CSSEPCVHGG RCREGWNRHV CDCTGTGYMG PNCEMESAVL SYDGSMFLKV LMPHAAHSEA EDVSLRFMSQ RAYGLLMATT SKESADTLRL ELDGGRVKLT VNLDCIGIDC NLSKGPETLF AGHKLNDNEW HSVKVVRRGK SLQLSVDNVT VEGQMSGAHT QLEFHHIETG IMTERRFISV MPSNFIGHLQ GLSFNGMPYL DQCKNGDISY CELNARFGMR RIVADPVSFR NRASYVALST LQAYASMHLF FQFKTTSPDG LILFNSGDGS DFIVIELVKG YIHYVFDLGN GPSLMKGNSD KPLNDNQWHN VMVSRDDSNV HTLKIDSRTV TQHSNGARNL DLKGELYIGG VGKSMYNSLP KLIASRDGYQ GCLASVDLNG RLSDLIADAL HRVGQVERGC EAGPGTTCTE DSCSNQGVCL QQWEGFTCDC TMTTYGGPLC SDPGTTYIFG RGGALITYTW APNDRPSTRA DRLAVGFSTQ QSDAILVQVE SSQGLGDYLQ LHIEQGKVGV IFNVGTDDIT IDEPAVTVND GKYHVVRFTR SGGNATLQVD NQPVIERFPS GRQLTIFNSQ AAIKVGGQDK GRPFQGQISG LYYNGLQVLK LAAEGDPNVQ VAGNLRLVGD APSVLSTETT SATPPAAADM STTIMETTTT MATTTTRRQR SPSLKDSITQ NSDDLLVASA ECPSDDEDLE ECEPGTGGEL VLPIITVDTQ DPISMATRYP AIPAPPTSLT PLQTTKESLI LSDPRPPCPP DQEDCGDPME VSAFGSGEMT ESDDEDFNRN SPMVTDRTVL PPPPGVGKSG HGDHRPPVPA PTTHPNQLHI PAGKMNTRDQ VLLPPVPSSR HTPGLTYPPD FPHVPTAHPT DLMEKGRPGA VEVIRESSST TGMVVGIVAA AALCILILLY AMYKYRNRDE GSYQVDQSRN SGSESNGAVV KEKTPSTTAA VAKTTTKGKK NKDKEYYV //