ID A0A8M9PHR9_DANRE Unreviewed; 2773 AA. AC A0A8M9PHR9; F1QL44; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 13-SEP-2023, entry version 7. DE SubName: Full=Filamin C, gamma b (actin-binding protein 280) {ECO:0000313|Ensembl:ENSDARP00000024947}; DE SubName: Full=Filamin-C isoform X1 {ECO:0000313|RefSeq:XP_009298480.1, ECO:0000313|RefSeq:XP_021330897.1}; GN OrderedLocusNames=flncb {ECO:0000313|Ensembl:ENSDARP00000024947, GN ECO:0000313|RefSeq:XP_009298480.1, ECO:0000313|RefSeq:XP_021330897.1, GN ECO:0000313|ZFIN:ZDB-GENE-041008-175}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_021330897.1}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000024947} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024947}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000024947, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024947}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|RefSeq:XP_009298480.1, ECO:0000313|RefSeq:XP_021330897.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009298480.1, RC ECO:0000313|RefSeq:XP_021330897.1}; RG RefSeq; RL Submitted (MAR-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the filamin family. CC {ECO:0000256|ARBA:ARBA00009238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX470230; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009298480.1; XM_009300205.3. DR RefSeq; XP_021330897.1; XM_021475222.1. DR STRING; 7955.ENSDARP00000024947; -. DR Ensembl; ENSDART00000026492.9; ENSDARP00000024947.8; ENSDARG00000018820.11. DR GeneID; 570288; -. DR KEGG; dre:570288; -. DR CTD; 570288; -. DR ZFIN; ZDB-GENE-041008-175; flncb. DR eggNOG; KOG0518; Eukaryota. DR HOGENOM; CLU_000783_0_0_1; -. DR OMA; YPVMAGK; -. DR OrthoDB; 298396at2759; -. DR TreeFam; TF313685; -. DR Reactome; R-DRE-446353; Cell-extracellular matrix interactions. DR Proteomes; UP000000437; Chromosome 4. DR Bgee; ENSDARG00000018820; Expressed in tail bud paraxial mesoderm and 28 other tissues. DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt. DR GO; GO:0051015; F:actin filament binding; IEA:InterPro. DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN. DR GO; GO:0007507; P:heart development; IMP:ZFIN. DR GO; GO:0007626; P:locomotory behavior; IMP:ZFIN. DR GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:ZFIN. DR GO; GO:0045214; P:sarcomere organization; IMP:ZFIN. DR Gene3D; 1.10.418.10; Calponin-like domain; 2. DR Gene3D; 2.60.40.10; Immunoglobulins; 24. DR InterPro; IPR001589; Actinin_actin-bd_CS. DR InterPro; IPR001715; CH_dom. DR InterPro; IPR036872; CH_dom_sf. DR InterPro; IPR044801; Filamin. DR InterPro; IPR017868; Filamin/ABP280_repeat-like. DR InterPro; IPR001298; Filamin/ABP280_rpt. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR PANTHER; PTHR38537:SF8; FILAMIN-A; 1. DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1. DR Pfam; PF00307; CH; 2. DR Pfam; PF00630; Filamin; 23. DR SMART; SM00033; CH; 2. DR SMART; SM00557; IG_FLMN; 24. DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1. DR SUPFAM; SSF81296; E set domains; 24. DR PROSITE; PS00019; ACTININ_1; 1. DR PROSITE; PS00020; ACTININ_2; 1. DR PROSITE; PS50021; CH; 2. DR PROSITE; PS50194; FILAMIN_REPEAT; 24. PE 1: Evidence at protein level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A8M9PHR9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 45..151 FT /note="Calponin-homology (CH)" FT /evidence="ECO:0000259|PROSITE:PS50021" FT DOMAIN 168..271 FT /note="Calponin-homology (CH)" FT /evidence="ECO:0000259|PROSITE:PS50021" FT REPEAT 279..377 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 379..477 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 519..615 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 616..708 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 712..808 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 809..911 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 912..1010 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1011..1106 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1107..1199 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1200..1294 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1295..1394 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1395..1487 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1488..1583 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1584..1680 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1693..1784 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1833..1902 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1902..1994 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 1992..2081 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 2084..2176 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 2251..2355 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 2358..2450 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 2452..2545 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 2549..2641 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REPEAT 2678..2772 FT /note="Filamin" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087" FT REGION 1..39 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 484..532 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2230..2315 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..18 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 505..521 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2231..2258 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2282..2311 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2773 AA; 297889 MW; 32865ABF7CEA3D46 CRC64; MMSNNTYYDQ QLPPQYYQGT DNGEDGDEEM PATEKDLAED APWKKIQQNT FTRWCNEHLK CLNRKILDLQ KDLTDGLKLI GLLEVLSQKK MYRKYHARPN FRQMKLENVS VALEFLEREH IKLVSIDSKA IVDGNLKLIL GLIWTLILHY SISMPMWEDE DDEDARKLTP KQRLLGWIQN KVPQLHINNF HRDWRDGKAL GALVDNCAPG LCPDWETWDP SQPVENAREA MQQADDWLGV PQVIAPEEIV DPNVDEHSVM TYLSQFPKAK LKPGAPLRPK TLHPKRAKAY GPGIEPRGNV VLKPAEFVVE TVEAGLGEVL VYIEDPEGHT EEARVIPNND RNRSYSVVYV PKVEGLHKVK VLFAGQDIDR SPFLVNVSKA LGDPNKVQAR GPGLEPVGNV ANKPTYFDIY TAGAGAGDVG VIIVDSQGRR DTVEIILENK GDSVFRCTYG PILEGPHTIY VTFAGQQIPR SPFTVHISEA PPHGRQIGSP VHIIPQSLRT PPSEKAKKVP PPTPPKPRRP TSNPNACRAI GRGLQPKGVR VKEVADFKVY TKGAGSGELR VHVKGPTGGD EPVKVEDLGD GVYECDYYPI FCGKYIITVT WGGHAIPRSP FEVIISEDAG PQKVRAWGPG LETGMVGKSA DFVVEAIGTE VGTLGFSIEG PSQAKIECDD KGDGSCDVLY WPTEPGDYAV HVICDDEDIK DSPFMAHILP AASDVFPEKV KCYGPGLEPT GCIVNKPAEF TIDARGAGRG QLQIYAQDSE GFPINIQITD NGDSTYFCVY IPIKPIKHTI IITWGEVNVP NSPFRVTIGE GSHPENVKVH GPGVEKTGLK ANEPTYFTVD CSEAGQGDVS IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR YTIMVLFADQ EIPISPFRIK VDPSHDANKV KAEGPGLNKT GVEVGKPTHF TIYTKGAGKA TPEVHFTASG RGDAVSDFEI IDNHDYSFTV RYTALQQGNM TISVCHGGDP IPKSPFTISV APPLDLNKVK VHGLNNKVDV GKDEEFTVNT RGAGGQGKVD VKITSPSRRP IPCKVESGAS NEVHTVKYIP PEEGPYKVDI SYDGNPVPGS PFTVEGVMPP DPSKVRAYGP GLKGGIVGKP APFAIDTKGA GTGGLGLTVE GPCEAKIECQ DNGDGSCSVS YLPTEPGEYS INILFADAHI PGSPFKAMVQ SVFDPSKVTA SGPGLERGKV NEAGSFTVDC SKAGEAELTI EIISDSGAQA EVHVQNNSDG TYSITYIPPF HGMYTITIKY GGHAVPKFPA RVQVDPALDT SGIKVYGPGV EPRGVLREVT THFIVDTRVH NKMGGNHIKV RIVNPSGANT DAYVTDKADG TYRVEYTAYE DGVHLIEVLY DDVPVPKSPF RVAVAEGCDP SRVRAYGPGL EEGLVNKPNR FTVETRGAGT GGLGLAIEGP SEAKMSCKDN KDGSCSVEYI PFTPGEYDVN ITFGGLPIPG SPFRVPVREL VDPSKVKCTG PGLGSGVRAH VPQTFTVDCS KAGLAPLEVL LYGPTGMTEP VNITDNGDGT HTVVYTPAKD GPYTVCVKYA DQEVPRSPFK IKVLPAHDAS KVRASGPGLN ASGVPASLPV EFTIDARDAG EGLLTVQILD PEGKPKKANI RDNRDGTYTV SYVPDMTGRY TITIKYGGDE IPYSPYRIHA LPSGDASKCL VTVSIGGHGL GSGLGPTIQI GEETVITVDA KAAGKGKVTC KVSTPDGAEL DVDVVENADG TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVVASDTIPI IEEPCDKLQL QQPYAPYQGY SPHWATEEPV TAVDIIEPVL RPFNLVIPFT VQKGEITGEV HMPSGKTASP HITDNKDGTV TVKYAPTEKG LHEMDIKYDG NHIPGSPLQF YVDAINSGHV NAYGPGLSHG MVNKSATFTI VTKDAGEGGL SLAVEGPSKA EISCKDNKDG TCTVSYLPTA PGDYNIIVKF DDKHIAGSPF TAKITGDDSM RTSQLNVGTA TDVSLKITET DLSSLSATIR APSGNEEPCL LKRLPNRHIG ISFTPKEVGE HVVSVKKNGK HVTNSPFKIM VGQSEIGDAS KVKVSGKGLI EGHTFEVAEF IVDTRSAGYG GLGLSIEGPS KVDINCSDVD DGTCKVTYCP TEPGTYIINI KFADQHVPGS PFTVKVLGEG RMKESITRKR QAPSIATVGS TCDLNLKIPG NWFQMVSAQE RLTRTFTRSS HTYTRTERTE ISKTRAGETK REVRVEESTQ VGGDPFRDVF GGFMGRESLG PFNSPQGRQS EGESGTQEMT AQVTSPSGNT EDAEIIEGED STYSVRFVPH EMGPHTVNVK YRGQHVPGSP FQFTVGPLGE GGAHKVRAGG TGLDRGVAGV PAEFSIWTRE AGAGGLSIAV EGPSKAEISF EDRKDGSCGV AYIVQEPGDY EVSIKFNDEH IPDSPFIVPI ASLSDDARLL TVTSLQEMGL KVNQEASFAV QLNGARGAID AKVHTPSGAV EECYITELDN DKHAIRFIPR ENGVHSIDVR FNGSHIPGSP FKIRVGEPGQ AGDPGMVTAF GPGLEGGTTG VPSDFIVNTC NAGSGALSVT IDGPSKVKMD CQECPEGYKV TYTPMAPGSY LISIKYGGPQ HIVGSPFKAK VSGARLSGGH SLHETSSVLV ETVTKSSSVA GSFSTLPKFS SDASKVVSRG AGLSKAFIGQ KNTFTVDCSK AGTNMLMVGV HGPKTPCEEV YVKHMGNRMY NVTYTVKEKG DYILIVKWGE EMVPGSPFHV TVP //