ID   A0A8M9PHR9_DANRE        Unreviewed;      2773 AA.
AC   A0A8M9PHR9; F1QL44;
DT   03-AUG-2022, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=Filamin C, gamma b (actin-binding protein 280) {ECO:0000313|Ensembl:ENSDARP00000024947};
DE   SubName: Full=Filamin-C isoform X1 {ECO:0000313|RefSeq:XP_009298480.1, ECO:0000313|RefSeq:XP_021330897.1};
GN   Name=flncb {ECO:0000313|Ensembl:ENSDARP00000024947,
GN   ECO:0000313|RefSeq:XP_009298480.1, ECO:0000313|RefSeq:XP_021330897.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-041008-175};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_021330897.1};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000024947}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024947};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000024947, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024947};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:XP_009298480.1, ECO:0000313|RefSeq:XP_021330897.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009298480.1,
RC   ECO:0000313|RefSeq:XP_021330897.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the filamin family.
CC       {ECO:0000256|ARBA:ARBA00009238}.
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DR   EMBL; BX470230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009298480.1; XM_009300205.3.
DR   RefSeq; XP_021330897.1; XM_021475222.1.
DR   STRING; 7955.ENSDARP00000024947; -.
DR   PaxDb; 7955-ENSDARP00000024947; -.
DR   Ensembl; ENSDART00000026492; ENSDARP00000024947; ENSDARG00000018820.
DR   Ensembl; ENSDART00000026492.9; ENSDARP00000024947.8; ENSDARG00000018820.11.
DR   GeneID; 570288; -.
DR   KEGG; dre:570288; -.
DR   AGR; ZFIN:ZDB-GENE-041008-175; -.
DR   CTD; 570288; -.
DR   ZFIN; ZDB-GENE-041008-175; flncb.
DR   eggNOG; KOG0518; Eukaryota.
DR   HOGENOM; CLU_000783_0_0_1; -.
DR   OMA; YPVMAGK; -.
DR   OrthoDB; 298396at2759; -.
DR   TreeFam; TF313685; -.
DR   Reactome; R-DRE-446353; Cell-extracellular matrix interactions.
DR   Proteomes; UP000000437; Chromosome 4.
DR   Bgee; ENSDARG00000018820; Expressed in tail bud paraxial mesoderm and 28 other cell types or tissues.
DR   GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0007626; P:locomotory behavior; IMP:ZFIN.
DR   GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:ZFIN.
DR   GO; GO:0045214; P:sarcomere organization; IMP:ZFIN.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR044801; Filamin.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR001298; Filamin/ABP280_rpt.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR   PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF00630; Filamin; 24.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00557; IG_FLMN; 24.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF81296; E set domains; 24.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE   1: Evidence at protein level;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:A0A8M9PHR9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          45..151
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          168..271
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REPEAT          279..377
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          379..477
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          519..615
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          616..708
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          712..808
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          809..911
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          912..1010
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1011..1106
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1107..1199
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1200..1294
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1295..1394
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1395..1487
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1488..1583
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1584..1680
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1693..1784
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1833..1902
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1902..1994
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          1992..2081
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          2084..2176
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          2251..2355
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          2358..2450
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          2452..2545
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          2549..2641
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          2678..2772
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2230..2315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..521
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2231..2258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2282..2311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2773 AA;  297889 MW;  32865ABF7CEA3D46 CRC64;
     MMSNNTYYDQ QLPPQYYQGT DNGEDGDEEM PATEKDLAED APWKKIQQNT FTRWCNEHLK
     CLNRKILDLQ KDLTDGLKLI GLLEVLSQKK MYRKYHARPN FRQMKLENVS VALEFLEREH
     IKLVSIDSKA IVDGNLKLIL GLIWTLILHY SISMPMWEDE DDEDARKLTP KQRLLGWIQN
     KVPQLHINNF HRDWRDGKAL GALVDNCAPG LCPDWETWDP SQPVENAREA MQQADDWLGV
     PQVIAPEEIV DPNVDEHSVM TYLSQFPKAK LKPGAPLRPK TLHPKRAKAY GPGIEPRGNV
     VLKPAEFVVE TVEAGLGEVL VYIEDPEGHT EEARVIPNND RNRSYSVVYV PKVEGLHKVK
     VLFAGQDIDR SPFLVNVSKA LGDPNKVQAR GPGLEPVGNV ANKPTYFDIY TAGAGAGDVG
     VIIVDSQGRR DTVEIILENK GDSVFRCTYG PILEGPHTIY VTFAGQQIPR SPFTVHISEA
     PPHGRQIGSP VHIIPQSLRT PPSEKAKKVP PPTPPKPRRP TSNPNACRAI GRGLQPKGVR
     VKEVADFKVY TKGAGSGELR VHVKGPTGGD EPVKVEDLGD GVYECDYYPI FCGKYIITVT
     WGGHAIPRSP FEVIISEDAG PQKVRAWGPG LETGMVGKSA DFVVEAIGTE VGTLGFSIEG
     PSQAKIECDD KGDGSCDVLY WPTEPGDYAV HVICDDEDIK DSPFMAHILP AASDVFPEKV
     KCYGPGLEPT GCIVNKPAEF TIDARGAGRG QLQIYAQDSE GFPINIQITD NGDSTYFCVY
     IPIKPIKHTI IITWGEVNVP NSPFRVTIGE GSHPENVKVH GPGVEKTGLK ANEPTYFTVD
     CSEAGQGDVS IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR YTIMVLFADQ
     EIPISPFRIK VDPSHDANKV KAEGPGLNKT GVEVGKPTHF TIYTKGAGKA TPEVHFTASG
     RGDAVSDFEI IDNHDYSFTV RYTALQQGNM TISVCHGGDP IPKSPFTISV APPLDLNKVK
     VHGLNNKVDV GKDEEFTVNT RGAGGQGKVD VKITSPSRRP IPCKVESGAS NEVHTVKYIP
     PEEGPYKVDI SYDGNPVPGS PFTVEGVMPP DPSKVRAYGP GLKGGIVGKP APFAIDTKGA
     GTGGLGLTVE GPCEAKIECQ DNGDGSCSVS YLPTEPGEYS INILFADAHI PGSPFKAMVQ
     SVFDPSKVTA SGPGLERGKV NEAGSFTVDC SKAGEAELTI EIISDSGAQA EVHVQNNSDG
     TYSITYIPPF HGMYTITIKY GGHAVPKFPA RVQVDPALDT SGIKVYGPGV EPRGVLREVT
     THFIVDTRVH NKMGGNHIKV RIVNPSGANT DAYVTDKADG TYRVEYTAYE DGVHLIEVLY
     DDVPVPKSPF RVAVAEGCDP SRVRAYGPGL EEGLVNKPNR FTVETRGAGT GGLGLAIEGP
     SEAKMSCKDN KDGSCSVEYI PFTPGEYDVN ITFGGLPIPG SPFRVPVREL VDPSKVKCTG
     PGLGSGVRAH VPQTFTVDCS KAGLAPLEVL LYGPTGMTEP VNITDNGDGT HTVVYTPAKD
     GPYTVCVKYA DQEVPRSPFK IKVLPAHDAS KVRASGPGLN ASGVPASLPV EFTIDARDAG
     EGLLTVQILD PEGKPKKANI RDNRDGTYTV SYVPDMTGRY TITIKYGGDE IPYSPYRIHA
     LPSGDASKCL VTVSIGGHGL GSGLGPTIQI GEETVITVDA KAAGKGKVTC KVSTPDGAEL
     DVDVVENADG TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVVASDTIPI IEEPCDKLQL
     QQPYAPYQGY SPHWATEEPV TAVDIIEPVL RPFNLVIPFT VQKGEITGEV HMPSGKTASP
     HITDNKDGTV TVKYAPTEKG LHEMDIKYDG NHIPGSPLQF YVDAINSGHV NAYGPGLSHG
     MVNKSATFTI VTKDAGEGGL SLAVEGPSKA EISCKDNKDG TCTVSYLPTA PGDYNIIVKF
     DDKHIAGSPF TAKITGDDSM RTSQLNVGTA TDVSLKITET DLSSLSATIR APSGNEEPCL
     LKRLPNRHIG ISFTPKEVGE HVVSVKKNGK HVTNSPFKIM VGQSEIGDAS KVKVSGKGLI
     EGHTFEVAEF IVDTRSAGYG GLGLSIEGPS KVDINCSDVD DGTCKVTYCP TEPGTYIINI
     KFADQHVPGS PFTVKVLGEG RMKESITRKR QAPSIATVGS TCDLNLKIPG NWFQMVSAQE
     RLTRTFTRSS HTYTRTERTE ISKTRAGETK REVRVEESTQ VGGDPFRDVF GGFMGRESLG
     PFNSPQGRQS EGESGTQEMT AQVTSPSGNT EDAEIIEGED STYSVRFVPH EMGPHTVNVK
     YRGQHVPGSP FQFTVGPLGE GGAHKVRAGG TGLDRGVAGV PAEFSIWTRE AGAGGLSIAV
     EGPSKAEISF EDRKDGSCGV AYIVQEPGDY EVSIKFNDEH IPDSPFIVPI ASLSDDARLL
     TVTSLQEMGL KVNQEASFAV QLNGARGAID AKVHTPSGAV EECYITELDN DKHAIRFIPR
     ENGVHSIDVR FNGSHIPGSP FKIRVGEPGQ AGDPGMVTAF GPGLEGGTTG VPSDFIVNTC
     NAGSGALSVT IDGPSKVKMD CQECPEGYKV TYTPMAPGSY LISIKYGGPQ HIVGSPFKAK
     VSGARLSGGH SLHETSSVLV ETVTKSSSVA GSFSTLPKFS SDASKVVSRG AGLSKAFIGQ
     KNTFTVDCSK AGTNMLMVGV HGPKTPCEEV YVKHMGNRMY NVTYTVKEKG DYILIVKWGE
     EMVPGSPFHV TVP
//