ID A0A8M3BEJ1_DANRE Unreviewed; 1260 AA. AC A0A8M3BEJ1; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 22-FEB-2023, entry version 4. DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574}; GN Name=dctn1b {ECO:0000313|RefSeq:XP_009305475.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_009305475.1}; RN [1] {ECO:0000313|RefSeq:XP_009305475.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009305475.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton CC {ECO:0000256|ARBA:ARBA00004245}. CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family. CC {ECO:0000256|ARBA:ARBA00011010}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_009305475.1; XM_009307200.3. DR GeneID; 100003026; -. DR KEGG; dre:100003026; -. DR CTD; 100003026; -. DR Proteomes; UP000000437; Chromosome 13. DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell. DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW. DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1. DR InterPro; IPR036859; CAP-Gly_dom_sf. DR InterPro; IPR000938; CAP-Gly_domain. DR InterPro; IPR022157; Dynactin. DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1. DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1. DR Pfam; PF01302; CAP_GLY; 1. DR Pfam; PF12455; Dynactin; 1. DR SMART; SM01052; CAP_GLY; 1. DR SUPFAM; SSF74924; Cap-Gly domain; 1. DR PROSITE; PS00845; CAP_GLY_1; 1. DR PROSITE; PS50245; CAP_GLY_2; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212}; KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}; KW Dynein {ECO:0000256|ARBA:ARBA00023017}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 50..92 FT /note="CAP-Gly" FT /evidence="ECO:0000259|PROSITE:PS50245" FT REGION 1..28 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 130..215 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 946..1037 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1080..1107 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1167..1194 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 133..151 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 167..182 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 184..207 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1260 AA; 140642 MW; 1F95513F71499D8C CRC64; MSQMKRYTYS RTTSSGSSRM SSDGGGRPVK VGSLVEVIGK GHRGTVAYIG NTLFASGKWV GVILDEPKGK NDGTVQGKRY FLCQENHGIF VRQSQIQLVE DGADTTSPET PEALTSKMLK REIIEGLKSN KVRGTKPKKA PTTRKTTTRR PKQTRAGVGV KVGSGSASAG EMSSSEPSTP AQTPLAAPVI PSPVGALPSP GAPPIPGPSK EEESLRALVK DLEEKLETLK MKRTEDKAKL KELEKHKIQL EQLQEWKSKM QEQQNELQKQ LKEAKREAKE ALEAKERYME EMADTADAIE MATLDKEMAE ERAESLQLEA DALKERVDEL TMDLEILKHE IEEKGSDGAA SSYHVKQLEE QNARLKEALV RMRDLSASEK QEHGKQQKLM EKKNFELDAL RCHKEKLQEE MKMAEKTIDE LKEQVDASLG AEEMVEMLTE RNLDLEEKVR ELRETVADLE AINEMNDELQ ENARETELEL REQLDLGAAG VREAEKRVEA AQETVADYQQ TIQKYRELTA NLQEVNRELM SQQEANSEQQ QQPAEIFDFK IKFAETKAYA KAIEMELRKM EVIQANRQVS LLISFMPDSF LKHRGDHDCI LALLLIPRLI CKSELISKQA QEKFELTESC SQKPGMRGAV GERLSFAAGL IYSLTLLQAA LHKYEHALSQ CSVDVYKRVG SLYSELSVHE RSLDFLIDLL YKDLLDETVN VEPLTKAIKY YQHLYSIHLA EQPEDCTMQL ADHIRFTQSA LDCMAVEVGR LRAFIQTGQD EEAFCVLLKD LDTSCSDIRQ FCKKIRRRMP GTDAPGIPAA LSFGPQVCEA LADSRRQLAW VNAVLQEVAA AAAQLIAPLS EHEGLPAVKL EDMAFKAAEQ IYGSQGINAQ ECLRQSCSVV IATMNKMATA MQEGEYDSDR PQTGISPVEV RAAALRAEIT DAEGLGLKLE DRETVIKELK KSLKIKGEEL SEANVRLSLL EKKLDSASKD ADERVEKIQA ILDETDSLLK KKEKEFEETM DALQADIDQL ESEKVELKHR ISSQSKMTIE SLRGSQASGI ASIVTCGITA GVCAAAGLQV IDSPLLTQQI EAQRLSIKHL KNENNRLKAE RMRAQLASLP PLNVPKLGWR EGCRPEVLSS ALYRKTDQLL DTLLQMSANV KVVDITGRSP VSPSAQLLEQ TARLQSLNDT LDRLKDEVAE HVVTHRPGAQ VSSDFATFPC TSFVKAKEEK RGDAVLVGRV MMPCARGQEQ VHRLVLSQTQ IHRVHRLLQT //