ID A0A8M3B129_DANRE Unreviewed; 2310 AA. AC A0A8M3B129; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 08-NOV-2023, entry version 8. DE SubName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X21 {ECO:0000313|RefSeq:XP_009297866.1}; GN Name=cacna1aa {ECO:0000313|RefSeq:XP_009297866.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_009297866.1}; RN [1] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|RefSeq:XP_009297866.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009297866.1}; RG RefSeq; RL Submitted (JUL-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi- CC pass membrane protein {ECO:0000256|RuleBase:RU003808}. CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_009297866.1; XM_009299591.3. DR GeneID; 562059; -. DR CTD; 562059; -. DR Proteomes; UP000000437; Chromosome 3. DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro. DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IEA:UniProtKB-KW. DR Gene3D; 1.10.287.70; -; 4. DR Gene3D; 6.10.250.2180; -; 1. DR Gene3D; 6.10.250.2500; -; 1. DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4. DR InterPro; IPR031649; GPHH_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR014873; VDCC_a1su_IQ. DR InterPro; IPR002077; VDCCAlpha1. DR InterPro; IPR027359; Volt_channel_dom_sf. DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1. DR PANTHER; PTHR45628:SF3; VOLTAGE-DEPENDENT P/Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A; 1. DR Pfam; PF08763; Ca_chan_IQ; 1. DR Pfam; PF16905; GPHH; 1. DR Pfam; PF00520; Ion_trans; 4. DR PRINTS; PR00167; CACHANNEL. DR SMART; SM01062; Ca_chan_IQ; 1. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673, KW ECO:0000256|RuleBase:RU003808}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568, KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils}; KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3}; KW Ion channel {ECO:0000256|RuleBase:RU003808}; KW Ion transport {ECO:0000256|ARBA:ARBA00022568, KW ECO:0000256|RuleBase:RU003808}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR602077-1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808}; KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}. FT TRANSMEM 93..110 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 131..152 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 164..184 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 219..242 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 295..316 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 328..350 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 472..491 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 503..523 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 535..555 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 598..620 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 673..698 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1140..1159 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1179..1200 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1212..1230 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1274..1296 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1387..1412 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1466..1483 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1495..1521 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1589..1607 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1679..1703 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1841..1875 FT /note="Voltage-dependent calcium channel alpha-1 subunit FT IQ" FT /evidence="ECO:0000259|SMART:SM01062" FT REGION 1..41 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 816..1000 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1084..1117 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1882..1910 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1932..2310 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 694..721 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 829..859 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 890..904 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 915..977 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 978..1000 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1954..1968 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1977..1999 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2016..2036 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2046..2063 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2064..2098 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2099..2139 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2171..2187 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2230..2255 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 309 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1" FT BINDING 652 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1" FT BINDING 1358 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1" FT CARBOHYD 274 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3" SQ SEQUENCE 2310 AA; 262654 MW; EEFCE287E77B6F2D CRC64; MARFGDEVPS RYGGGPGHAQ GGPGRGGSRQ GGPPGAQQRM YKQSMAQRAR TMALYNPIPV RQNCFTVNRS LFIFSEDNFV RKYAKKITEW PPFEYMILAT IIANCIVLAL EQHLPDGDKT PMSERLEDTE PYFIGIFCFE SGIKILALGF AFHKGSYLRN GWNVMDFVVV LTGILSTVGS DFDLRTLRAV RVLRPLKLVS GIPSLQVVLK SIMKAMIPLL QIGLLLFFAI LMFAIIGLEF YMGKFHTTCF DKITDEIREE FPCGEEVPAR ICPNGTVCKK YWLGPNYGIT QFDNILFAVL TVFQCITMEG WTDLLYYSND AAGSAWNWMY FIPLIIIGSF FMLNLVLGVL SGEFAKERER VENRSEFLKL KRQQQIEREL NGYLEWICKA EEVILADEDN DPDDRMPFDG SRRRPTIKKS KTDLLDAEDG DGDIGSPFAR GSLKSSKLEG SSFHKKERRL RFFIRRIVKT QAFYWTVLCL VGLNTLCVAV VHYDQPETLS DFLYFAEFIF LGIFMSEMCI KMYGLGTRPY FHSSFNCFDC IVICGSIFEV LWAMIQPGTS FGISVLRALR LLRIFKVTKY WASLRNLVVS LLNSMKSIIS LLFLLFLFIV VFALLGMQLF GGQFNFEAGT PPTNFDTFPA AIMTVFQILT GEDWNMVMYD GIESQGGVKK GMVFSVFFIV LTLFGNYTLL NVFLAIAVDN LANAQELTKD EQEEEQAANK KMALQTAKEV AEVSPLSAAN LSIAAVTVNS ERLDATEHFL DCKEQQKNHK GCKSVWEQRT SELRRQTLVN SREALYNELD PEDRWKVSYS RHIRPDMKTH LDRPLVVDPQ ENRNNNTNKT RPGDGQPQHS HQLLHKQPNF NEAETGGGGG SESWPALERG DSTGSRRSLL GSEHYEEGRE SHRRHQHSQH CSQARQHRKA AEGGGEPGGR RHRSKAKERG PECEHSDGGE RKHRRHRHEG EGRKERGVRH RNRRDGHASG PTLSTTRPIQ KTLSRQDSQY SEDLDNAMNN KLATQPHDSL LNLANTAHSA GLAHTGTESS LILTNPSSTI ANVTSIGHLG MKPEYTAVDI PPMFPSSNAI LQVNKNANTE PLPKKEDTKG DDDDDEKDDG GPKPMPPYTS MFILTTTNPF RRLCHYIVTL RYFEMCILLV IAMSSIALAA EDPVWPESPR NNVLRYFDYV FTGVFTFEML IKMVDLGLVL HQGSYFRDLW NILDFIVVSG ALVAFAFTGS SKGKDISTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVNS LKNVLNILIV YMLFMFIFAV VAVQLFKGRF FYCTDESKEF ERDCRGEYLV YERDNEVRSQ KREWKKYDFH YDNVLWALLT LFTVSTGEGW PQVLKHSVDA TYENQGPSPG YRMEMSIFYV VYFVVFPFFF VNIFVALIII TFQEQGDKMM EDYSLEKNER ACIDFAINAK PLTRHMPQNK QTFQYRMWEF VVSPPFEYTI MALIALNTIV LMMKYDGASL TYEDVLKYLN IVFTSLFSME CILKIIAFGA LNYFKDAWNI FDCVTVLGSI TDILVTELGN NFINLSFLRL FRAARLIKLL RQGETIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ LFGNIKIEEN SDSAITQHNN FRTFFQALML LFRSATGEAW HDIMLSCLGK KPCDILSDNP KPECGSEFAY LYFVSFIFLC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEYVRIWAE YDPAACGRIH YKDMYSLLRV IDPPLGLGKK CPHRVACKRL LRMDLPVADD NTVHFNSTLM ALIRTALDIK IAKGGVDKHQ MDAELRKEMM AIWPNLSQKN LDLLVTPHKS ATDLTVGKIY AAMMIMEYYR QSKAKRTQAL HDEQNRTPLM FQRLEPPSPS QDVGPGLTGL PDTQMHPANH LPVDERIPES QSWVTARAQE ISQKAGNWSP EGQHPDDTTD NRRQSQPITD NSPMKRSASS LGHGRAGRSM RGEDYAMERV IPEEGHRHGH RHRDRSHRAS ERSLSRYTDA DTGLGTDLST TTQSGDLPSK ERDRGRAKDR KHHHHHHHHH GSLDKEHYGH ERDRGEYGHR QSRERDRRWS RSPSEGRECL THRQGSSSVS GSPVPSTSGT STPRRGRRQL PQTPATPRPH VTYSPVVRKP ISSTPPPGQQ SRLPTPTSRR FSPTGPEPPL PPHHHPSPPH HGSPRSGRHA HWGPEPAESV EGDGFYDDQD YEFNHHEPPS YEQSPVQGNP HPHSPRTSRH NTPPQGQAHP RRMPNGYRSS SPSPHHHAPA HPGTHKPPHP RGPRKGLHEP YSETDEDDWC //