ID A0A8M3AYX5_DANRE Unreviewed; 1258 AA. AC A0A8M3AYX5; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 29-MAY-2024, entry version 11. DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574}; GN Name=dctn1b {ECO:0000313|RefSeq:XP_009305476.1, GN ECO:0000313|ZFIN:ZDB-GENE-050419-28}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_009305476.1}; RN [1] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|RefSeq:XP_009305476.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009305476.1}; RG RefSeq; RL Submitted (FEB-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton CC {ECO:0000256|ARBA:ARBA00004245}. CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family. CC {ECO:0000256|ARBA:ARBA00011010}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_009305476.1; XM_009307201.3. DR GeneID; 100003026; -. DR AGR; ZFIN:ZDB-GENE-050419-28; -. DR CTD; 100003026; -. DR ZFIN; ZDB-GENE-050419-28; dctn1b. DR Proteomes; UP000000437; Chromosome 13. DR GO; GO:0030424; C:axon; IBA:GO_Central. DR GO; GO:0051286; C:cell tip; IEA:TreeGrafter. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW. DR GO; GO:0000776; C:kinetochore; IBA:GO_Central. DR GO; GO:0005875; C:microtubule associated complex; IBA:GO_Central. DR GO; GO:0035371; C:microtubule plus-end; IEA:TreeGrafter. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0000922; C:spindle pole; IBA:GO_Central. DR GO; GO:0051010; F:microtubule plus-end binding; IEA:TreeGrafter. DR GO; GO:0060219; P:camera-type eye photoreceptor cell differentiation; IGI:ZFIN. DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:TreeGrafter. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central. DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central. DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1. DR InterPro; IPR036859; CAP-Gly_dom_sf. DR InterPro; IPR000938; CAP-Gly_domain. DR InterPro; IPR022157; Dynactin. DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1. DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1. DR Pfam; PF01302; CAP_GLY; 1. DR Pfam; PF12455; Dynactin; 1. DR SMART; SM01052; CAP_GLY; 1. DR SUPFAM; SSF74924; Cap-Gly domain; 1. DR PROSITE; PS00845; CAP_GLY_1; 1. DR PROSITE; PS50245; CAP_GLY_2; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Dynein {ECO:0000256|ARBA:ARBA00023017}; KW Microtubule {ECO:0000256|ARBA:ARBA00022701}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 50..92 FT /note="CAP-Gly" FT /evidence="ECO:0000259|PROSITE:PS50245" FT REGION 1..28 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 131..209 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 940..1031 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1078..1105 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1165..1192 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 161..176 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 178..201 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1258 AA; 140502 MW; CFF54CB040BD2926 CRC64; MSQMKRYTYS RTTSSGSSRM SSDGGGRPVK VGSLVEVIGK GHRGTVAYIG NTLFASGKWV GVILDEPKGK NDGTVQGKRY FLCQENHGIF VRQSQIQLVE DGADTTSPET PEALTSKMLK REIIEGLKSN KVRGTKPKKT TTRRPKQTRA GVGVKVGSGS ASAGEMSSSE PSTPAQTPLA APVIPSPVGA LPSPGAPPIP GPSKEEESLR ALVKDLEEKL ETLKMKRTED KAKLKELEKH KIQLEQLQEW KSKMQEQQNE LQKQLKEAKR EAKEALEAKE RYMEEMADTA DAIEMATLDK EMAEERAESL QLEADALKER VDELTMDLEI LKHEIEEKGS DGAASSYHVK QLEEQNARLK EALVRMRDLS ASEKQEHGKQ QKLMEKKNFE LDALRCHKEK LQEEMKMAEK TIDELKEQVD ASLGAEEMVE MLTERNLDLE EKVRELRETV ADLEAINEMN DELQENARET ELELREQLDL GAAGVREAEK RVEAAQETVA DYQQTIQKYR ELTANLQEVN RELMSQQEAN SEQQQQPAEI FDFKIKFAET KAYAKAIEME LRKMEVIQAN RQVSLLISFM PDSFLKHRGD HDCILALLLI PRLICKSELI SKQAQEKFEL TESCSQKPGM RGAVGERLSF AAGLIYSLTL LQAALHKYEH ALSQCSVDVY KRVGSLYSEL SVHERSLDFL IDLLYKDLLD ETVNVEPLTK AIKYYQHLYS IHLAEQPEDC TMQLADHIRF TQSALDCMAV EVGRLRAFIQ TGQDEEAFCV LLKDLDTSCS DIRQFCKKIR RRMPGTDAPG IPAALSFGPQ VCEALADSRR QLAWVNAVLQ EVAAAAAQLI APLSEHEGLP AVKLEDMAFK AAEQIYGSQG INAQECLRQS CSVVIATMNK MATAMQEGEY DSDRPQTGIS PVEVRAAALR AEITDAEGLG LKLEDRETVI KELKKSLKIK GEELSEANVR LSLLEKKLDS ASKDADERVE KIQAILDETD SLLKKKEKEF EETMDALQAD IDQLESEKVE LKHRISSQSK MTIESLRGSQ ASGIASIVTC GITAEEQKGV CAAAGLQVID SPLLTQQIEA QRLSIKHLKN ENNRLKAERM RAQLASLPPL NVPKLGWREG CRPEVLSSAL YRKTDQLLDT LLQMSANVKV VDITGRSPVS PSAQLLEQTA RLQSLNDTLD RLKDEVAEHV VTHRPGAQVS SDFATFPCTS FVKAKEEKRG DAVLVGRVMM PCARGQEQVH RLVLSQTQIH RVHRLLQT //