ID A0A8M2BED6_DANRE Unreviewed; 517 AA. AC A0A8M2BED6; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 12-OCT-2022, entry version 2. DE SubName: Full=metalloprotease TIKI2 isoform X1 {ECO:0000313|RefSeq:XP_005166934.1}; GN Name=trabd2b {ECO:0000313|RefSeq:XP_005166934.1}; GN Synonyms=si:ch211-120j21.1 {ECO:0000313|RefSeq:XP_005166934.1}, TIKI2 GN {ECO:0000313|RefSeq:XP_005166934.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_005166934.1}; RN [1] {ECO:0000313|RefSeq:XP_005166934.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005166934.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- COFACTOR: CC Name=Co(2+); Xref=ChEBI:CHEBI:48828; CC Evidence={ECO:0000256|ARBA:ARBA00001941}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the TIKI family. CC {ECO:0000256|ARBA:ARBA00008261}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005166934.1; XM_005166877.3. DR GeneID; 566028; -. DR Proteomes; UP000000437; Chromosome 8. DR InterPro; IPR040230; TIKI1/2-like. DR InterPro; IPR002816; TraB/PrgY/GumN_fam. DR PANTHER; PTHR31120; PTHR31120; 1. DR Pfam; PF01963; TraB_PrgY_gumN; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Metalloprotease {ECO:0000313|RefSeq:XP_005166934.1}; KW Protease {ECO:0000313|RefSeq:XP_005166934.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..517 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5035474082" SQ SEQUENCE 517 AA; 59613 MW; 3088B99E652BFD35 CRC64; MNCQSGLRWL VTLCAFFQVG SARDTHESTR QCDKPVSKDM NSFLWTVKRP RPFPPSYLFG TIHVPYTRVW DYIPESSKRA FQTSNSVFFE LDLTDPLTIS KLTSCQLLPN GENLQTLLPR DLYRRLKRHL DYVKHMMPFW MTADQRGRGL YADYLFNAIA GNWERKRPVW VMLMVNSLTE ADVRSRGTPV LDLFLAQEAE RLGKQTGAVE RVEEQCHPLN GLNFSQVLFA LNQTLLQHES LRAGILQGTF TTEDLIAHYN CGDLNSIIFN HDTSQLPHFI NSSLPDHERL TAQQIDSYLR QELIYKRNER MARRVSALLQ RNPNQSFFFA FGAGHFLGNH SVLDILRQEG YEVEHTPPQE PIIQSWSERE ATTLNPTEDS FESVTEWTSE TPELEEISQE ELSHMLLPDS LSQLEEFGRY KHPRKTHHTH SRPRLFSDLW VRIGDSTTPH PSIRITNGYV TVEPPQIRQE QQQRLRERLK PLSEPTNPSA LDSAAPNPTY ALTCFLACLI SQLLFAS //