ID A0A8M2BBD6_DANRE Unreviewed; 1185 AA. AC A0A8M2BBD6; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 13-SEP-2023, entry version 7. DE SubName: Full=Potassium voltage-gated channel subfamily H member 6 isoform X1 {ECO:0000313|RefSeq:XP_005164064.1}; GN Name=kcnh6a {ECO:0000313|RefSeq:XP_005164064.1}; GN Synonyms=erg {ECO:0000313|RefSeq:XP_005164064.1}, kcnh2 GN {ECO:0000313|RefSeq:XP_005164064.1}, kcnh6 GN {ECO:0000313|RefSeq:XP_005164064.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_005164064.1}; RN [1] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|RefSeq:XP_005164064.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005164064.1}; RG RefSeq; RL Submitted (MAR-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005164064.1; XM_005164007.4. DR GeneID; 405763; -. DR CTD; 405763; -. DR Proteomes; UP000000437; Chromosome 3. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IEA:UniProtKB-KW. DR CDD; cd00038; CAP_ED; 1. DR CDD; cd00130; PAS; 1. DR Gene3D; 1.10.1200.260; -; 1. DR Gene3D; 1.10.287.70; -; 1. DR Gene3D; 2.60.120.10; Jelly Rolls; 1. DR Gene3D; 3.30.450.20; PAS domain; 1. DR InterPro; IPR000595; cNMP-bd_dom. DR InterPro; IPR018490; cNMP-bd_dom_sf. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG. DR InterPro; IPR003967; K_chnl_volt-dep_ERG. DR InterPro; IPR000014; PAS. DR InterPro; IPR035965; PAS-like_dom_sf. DR InterPro; IPR014710; RmlC-like_jellyroll. DR PANTHER; PTHR10217:SF638; ION_TRANS DOMAIN-CONTAINING PROTEIN-RELATED; 1. DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1. DR Pfam; PF00027; cNMP_binding; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF13426; PAS_9; 1. DR PRINTS; PR01463; EAGCHANLFMLY. DR PRINTS; PR01470; ERGCHANNEL. DR SMART; SM00100; cNMP; 1. DR SUPFAM; SSF51206; cAMP-binding domain-like; 1. DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1. DR PROSITE; PS50042; CNMP_BINDING_3; 1. PE 4: Predicted; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|ARBA:ARBA00022958}; KW Potassium channel {ECO:0000256|ARBA:ARBA00022826}; KW Potassium transport {ECO:0000256|ARBA:ARBA00022538}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}. FT TRANSMEM 372..396 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 512..538 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 583..599 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 611..635 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 714..814 FT /note="Cyclic nucleotide-binding" FT /evidence="ECO:0000259|PROSITE:PS50042" FT REGION 213..256 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 845..875 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1052..1185 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 237..256 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1054..1068 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1074..1096 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1107..1133 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1185 AA; 132198 MW; 35425945AAF00F70 CRC64; MPVRRGHVAL QNTYLDTIIR KFDGQNRKFL IANAQMKNCG IIYCNEGFCQ MFGFSRAEIM QQSCTCQFLV GPGTMKSALG QLAQALLGSE ERKVEILYYS KEGTCRPCLI DVIPVKNEEG VVIMFILNFQ ELLDPSMKKG GLKQRMANSW LRAGQRRRMH LRMPSLRVKR QPSLPKDHFE GVVVDYLQPS HEEVALKDLQ MSPDSCLKSE TQALIQQTPS SCELSPPPSR PSDRLEPSGP LLKHSHSRES MHSLRRASSL HDIDGMRDQW SDLKPSNLNS TSDSDLMRHR TIGRIPQVTI SFGSDRLRPP SPTEIEIIAP SKIKDRSQNV SEKVTQVTQV LSLGADVLPE YKLQAPRIHK WTILHYSPFK AVWDWIILLL VLYTAVFTPY SAAFLLNEQE DERRRTCGYT CNPLNVVDLV VDVMFIIDIL INFRTTYVNH NDEVVSNPAR IAQHYFKGWF LIDIVAAIPF DLLIFRSGSD EPQTTTLIGL LKTARLLRLV RVARKLDRYS EYGAAVLFLL MCTFALIAHW LACIWYAIGN MERTSSARIG GMKIGWLDNL ADQIGKQYND SNSFSGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNPEK IFSICVMLIG SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ IPGGLRQRLE EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLNRSLLQ NCKAFRGASK GCLRALAMRF RTTHAPPGDT LVHSGDVLTA LYFISRGSIE ILRDDVVVAI LGKNDIFGEP ISLYARPGKS SADVRALTYC DLHKILRDDL LEVLDMYPDF SDNFWSNLEI TFNLRDVDRI MHPTPSEDSD CGYRRPRHRR NPLRRNRPDG MDRDGMDTYP VQPCSPVGNH RGAIPLSQWD ELCSDGSPAS LSSEEDMKPL VSGQGDMYSL GTEMQEFSPS AVSLMPSAHS TASAMAGPLT GAHQYTAPLN ISGVYSYLSD RRASEYSESQ RRSSAVQACY HHHSPCVGDR PNQLQARLEL LQSQLNRLET RMTADINVIL QLLQRQMAPV PPAYSAVSPD PLAHPAPPAH PTSLYTTAAH NTTPSLQITD ASSPGKSPDV DSLKEKSPDS LSSGIHLTVA STDTMSMSPE TELSVPSAGP LLQPPGLLCS SLRFPSLPDS LEGPGTLEGS PEIQRHVSDP VLPGS //