ID A0A8M2BA12_DANRE Unreviewed; 1335 AA. AC A0A8M2BA12; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 12-OCT-2022, entry version 2. DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902}; DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136}; DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117}; DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820}; DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031}; GN Name=met {ECO:0000313|RefSeq:XP_005163052.1}; GN Synonyms=c-met {ECO:0000313|RefSeq:XP_005163052.1}, cmet GN {ECO:0000313|RefSeq:XP_005163052.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_005163052.1}; RN [1] {ECO:0000313|RefSeq:XP_005163052.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005163052.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005163052.1; XM_005162995.4. DR GeneID; 100150664; -. DR Proteomes; UP000000437; Chromosome 25. DR Gene3D; 2.130.10.10; -; 1. DR Gene3D; 2.60.40.10; -; 3. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR002909; IPT_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR031148; Plexin. DR InterPro; IPR002165; Plexin_repeat. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR016201; PSI. DR InterPro; IPR001627; Semap_dom. DR InterPro; IPR036352; Semap_dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR PANTHER; PTHR22625; PTHR22625; 2. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01437; PSI; 1. DR Pfam; PF01403; Sema; 1. DR Pfam; PF01833; TIG; 3. DR PIRSF; PIRSF000617; TyrPK_HGF-R; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00429; IPT; 4. DR SMART; SM00423; PSI; 1. DR SMART; SM00630; Sema; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF101912; SSF101912; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF81296; SSF81296; 3. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS51004; SEMA; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Kinase {ECO:0000256|ARBA:ARBA00023137}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, KW ECO:0000313|RefSeq:XP_005163052.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|ARBA:ARBA00023137}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..1335 FT /note="Hepatocyte growth factor receptor" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5035460351" FT TRANSMEM 932..954 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 27..510 FT /note="Sema" FT /evidence="ECO:0000259|PROSITE:PS51004" FT DOMAIN 1032..1295 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT BINDING 1064 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 1335 AA; 148831 MW; 9A68E813460D3351 CRC64; MTIHYSEAAS ILIILQSLWW GLNCQCEEPI ESSKLDLSVT YDLPYFVSDT PIQKLLEING TVYVGAVNRL YALSKDLKKK HEYKTGPVHE GPDCKTPTDQ CSGCENKPRN INNTNMALLM ETFYDLELFS CGSVGNGVCS RHVLEDGPLG AEVTCMYTKK NEGSSHGCPD CLAGPAGTQI LNIMSGRVVR FFVANSEPLE SNGPRLHHTI SIRKMRETQD GFEFFSDQSY MDLAPSLRGN YPLHYVYSFQ SGPYVYFLTV QREGGNSKAF HTRIVRMCSS DSEILRYVEM PFECIYSERR RKKRSAQVVF NVLQAAHVAK VGYDFQQEMG LKEGEDVLFA AFARSKPDSP EPTASSAVCL ISITDINEFF KVFIQKGYTR KLHHFPGSEE KTFNQTFVGD SFSCGKHERG YRLEVTSTNP RRDYFHGRFR NVLLTSIAVV PIQNHTVVSL GTAEGRVIQV VVSRFGKTEP HVDFRLDTLP VSSEMALLSP QHHNGSLLLI TGNKVSKLPV IGPGCEQLWT CSSCLLAPGF MGCGWCRTSN LCTRAPRCPQ SQWIQDSCPL LITSISPSSA PLRGQTNITI CGKNFGFNKK DRFDTKLIDV VVAGTKCKLE RKDSNNNRLV CGLDHVNWSS VDSVVTVRSG KEQAQKDGFS FVNPVIIEIF PEFGPQSGGT MLTISGSFLD SGNVQTVTVG NATCVLQSVS ATMLTCRTPP QPSPSQHKVQ LHIDGVIFEA PVSYTYNKNP HISSVQPKHS FISGGSTVTV NGFYLHSALQ PQMVLTAATE GKLFQVTCSH DEDKRNILCI TPSLKGLSVQ PPVATKMTFV LDGFSTDQYD LLYVEDPKFE EFQKPTVTPR GKKNILEIKV PPVNQEAVKN GEVLRVSNRT CESVTLVGNT LECTVPMELQ TAAKELEVEW KQATSSVILG RVILAQDQDY RILITGGVCV SILLLLLIAV FVWIKRKKHI NDQNLPLSQT ESCRPHLYAH SHVDLSPMLG PMEGDLASPL LPSTAPIDLG SLHPELLKEV QHVVIAREDL LLHVNEIIGR GHFGCVFHGT LLEPDGQKQH CAIKSLNRIT DIEEVSQFLK EGIIMKDFSH PNVLSLLGIC LPSEGSPLVV LPYMKHGDLR NFIRDESHNP TVKDLMGFGL QVAKGMEYLA SKKFVHRDLA ARNCMLDESY TVKVADFGLA RDVYDKEYYS VHNKHGVKLP VKWMALESLQ THKFTTKSDV WSFGVLLWEL MTRGAPPYSD VNSFDITVFL LQGRRLLQPE FCPDALYNVM IECWHPKPER RPTFSELVSR ISAIFSSFSG EHYILLNTTY VNIDKMTPYP SLISSQSNLD RDCCT //