ID A0A8M2BA12_DANRE Unreviewed; 1335 AA. AC A0A8M2BA12; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 27-MAR-2024, entry version 10. DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839}; DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902}; DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136}; DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117}; DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820}; DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031}; GN Name=met {ECO:0000313|RefSeq:XP_005163052.1, GN ECO:0000313|ZFIN:ZDB-GENE-041014-1}; GN Synonyms=c-met {ECO:0000313|RefSeq:XP_005163052.1}, cmet GN {ECO:0000313|RefSeq:XP_005163052.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_005163052.1}; RN [1] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|RefSeq:XP_005163052.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005163052.1}; RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the plexin family. CC {ECO:0000256|ARBA:ARBA00010297}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005163052.1; XM_005162995.4. DR GeneID; 100150664; -. DR AGR; ZFIN:ZDB-GENE-041014-1; -. DR CTD; 4233; -. DR ZFIN; ZDB-GENE-041014-1; met. DR Proteomes; UP000000437; Chromosome 25. DR GO; GO:0009925; C:basal plasma membrane; IBA:GO_Central. DR GO; GO:0043235; C:receptor complex; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0005008; F:hepatocyte growth factor receptor activity; IBA:GO_Central. DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro. DR GO; GO:0007411; P:axon guidance; IEA:UniProt. DR GO; GO:0016477; P:cell migration; IMP:ZFIN. DR GO; GO:0021953; P:central nervous system neuron differentiation; IMP:ZFIN. DR GO; GO:0021707; P:cerebellar granule cell differentiation; IMP:ZFIN. DR GO; GO:0021549; P:cerebellum development; IMP:ZFIN. DR GO; GO:0021587; P:cerebellum morphogenesis; IMP:ZFIN. DR GO; GO:0021603; P:cranial nerve formation; IMP:ZFIN. DR GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN. DR GO; GO:0001889; P:liver development; IMP:ZFIN. DR GO; GO:0014812; P:muscle cell migration; IMP:ZFIN. DR GO; GO:0007399; P:nervous system development; IBA:GO_Central. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0001764; P:neuron migration; IMP:ZFIN. DR GO; GO:0031016; P:pancreas development; IBA:GO_Central. DR GO; GO:0033339; P:pectoral fin development; IMP:ZFIN. DR GO; GO:0006909; P:phagocytosis; IBA:GO_Central. DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:ZFIN. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR CDD; cd01179; IPT_plexin_repeat2; 1. DR CDD; cd05058; PTKc_Met_Ron; 1. DR CDD; cd11248; Sema_MET_like; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 3. DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR002909; IPT_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR031148; Plexin. DR InterPro; IPR002165; Plexin_repeat. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR016201; PSI. DR InterPro; IPR001627; Semap_dom. DR InterPro; IPR036352; Semap_dom_sf. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR PANTHER; PTHR22625:SF61; HEPATOCYTE GROWTH FACTOR RECEPTOR; 1. DR PANTHER; PTHR22625; PLEXIN; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF01437; PSI; 1. DR Pfam; PF01403; Sema; 1. DR Pfam; PF01833; TIG; 3. DR PIRSF; PIRSF000617; TyrPK_HGF-R; 2. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00429; IPT; 4. DR SMART; SM00423; PSI; 1. DR SMART; SM00630; Sema; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF81296; E set domains; 3. DR SUPFAM; SSF103575; Plexin repeat; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR SUPFAM; SSF101912; Sema domain; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS51004; SEMA; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000617- KW 2}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR000617-3}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Kinase {ECO:0000256|ARBA:ARBA00023137}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|PIRSR:PIRSR000617-2}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, KW ECO:0000313|RefSeq:XP_005163052.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|ARBA:ARBA00023137}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..1335 FT /note="Hepatocyte growth factor receptor" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5035460351" FT TRANSMEM 932..954 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 27..510 FT /note="Sema" FT /evidence="ECO:0000259|PROSITE:PS51004" FT DOMAIN 1032..1295 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT ACT_SITE 1158 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-1" FT BINDING 1038..1046 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2" FT BINDING 1064 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2, FT ECO:0000256|PROSITE-ProRule:PRU10141" FT BINDING 1111..1114 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2" FT BINDING 1162 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2" FT MOD_RES 1188 FT /note="Phosphotyrosine; by autocatalysis" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4" FT MOD_RES 1189 FT /note="Phosphotyrosine; by autocatalysis" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4" FT MOD_RES 1303 FT /note="Phosphotyrosine; by autocatalysis" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4" FT MOD_RES 1310 FT /note="Phosphotyrosine; by autocatalysis" FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4" FT DISULFID 104..155 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 131..139 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 168..171 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 294..359 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 515..533 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 521..558 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 524..542 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" FT DISULFID 536..548 FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3" SQ SEQUENCE 1335 AA; 148831 MW; 9A68E813460D3351 CRC64; MTIHYSEAAS ILIILQSLWW GLNCQCEEPI ESSKLDLSVT YDLPYFVSDT PIQKLLEING TVYVGAVNRL YALSKDLKKK HEYKTGPVHE GPDCKTPTDQ CSGCENKPRN INNTNMALLM ETFYDLELFS CGSVGNGVCS RHVLEDGPLG AEVTCMYTKK NEGSSHGCPD CLAGPAGTQI LNIMSGRVVR FFVANSEPLE SNGPRLHHTI SIRKMRETQD GFEFFSDQSY MDLAPSLRGN YPLHYVYSFQ SGPYVYFLTV QREGGNSKAF HTRIVRMCSS DSEILRYVEM PFECIYSERR RKKRSAQVVF NVLQAAHVAK VGYDFQQEMG LKEGEDVLFA AFARSKPDSP EPTASSAVCL ISITDINEFF KVFIQKGYTR KLHHFPGSEE KTFNQTFVGD SFSCGKHERG YRLEVTSTNP RRDYFHGRFR NVLLTSIAVV PIQNHTVVSL GTAEGRVIQV VVSRFGKTEP HVDFRLDTLP VSSEMALLSP QHHNGSLLLI TGNKVSKLPV IGPGCEQLWT CSSCLLAPGF MGCGWCRTSN LCTRAPRCPQ SQWIQDSCPL LITSISPSSA PLRGQTNITI CGKNFGFNKK DRFDTKLIDV VVAGTKCKLE RKDSNNNRLV CGLDHVNWSS VDSVVTVRSG KEQAQKDGFS FVNPVIIEIF PEFGPQSGGT MLTISGSFLD SGNVQTVTVG NATCVLQSVS ATMLTCRTPP QPSPSQHKVQ LHIDGVIFEA PVSYTYNKNP HISSVQPKHS FISGGSTVTV NGFYLHSALQ PQMVLTAATE GKLFQVTCSH DEDKRNILCI TPSLKGLSVQ PPVATKMTFV LDGFSTDQYD LLYVEDPKFE EFQKPTVTPR GKKNILEIKV PPVNQEAVKN GEVLRVSNRT CESVTLVGNT LECTVPMELQ TAAKELEVEW KQATSSVILG RVILAQDQDY RILITGGVCV SILLLLLIAV FVWIKRKKHI NDQNLPLSQT ESCRPHLYAH SHVDLSPMLG PMEGDLASPL LPSTAPIDLG SLHPELLKEV QHVVIAREDL LLHVNEIIGR GHFGCVFHGT LLEPDGQKQH CAIKSLNRIT DIEEVSQFLK EGIIMKDFSH PNVLSLLGIC LPSEGSPLVV LPYMKHGDLR NFIRDESHNP TVKDLMGFGL QVAKGMEYLA SKKFVHRDLA ARNCMLDESY TVKVADFGLA RDVYDKEYYS VHNKHGVKLP VKWMALESLQ THKFTTKSDV WSFGVLLWEL MTRGAPPYSD VNSFDITVFL LQGRRLLQPE FCPDALYNVM IECWHPKPER RPTFSELVSR ISAIFSSFSG EHYILLNTTY VNIDKMTPYP SLISSQSNLD RDCCT //