ID A0A8M1P8Z2_DANRE Unreviewed; 388 AA. AC A0A8M1P8Z2; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 12-OCT-2022, entry version 2. DE RecName: Full=E3 ubiquitin-protein ligase E3D {ECO:0000256|ARBA:ARBA00013646}; DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485}; DE AltName: Full=HECT-type E3 ubiquitin transferase E3D {ECO:0000256|ARBA:ARBA00032298}; DE AltName: Full=UbcH10-binding protein with a HECT-like domain {ECO:0000256|ARBA:ARBA00032234}; DE AltName: Full=Ubiquitin-conjugating enzyme E2C-binding protein {ECO:0000256|ARBA:ARBA00029737}; GN Name=ube3d {ECO:0000313|RefSeq:NP_001313339.1}; GN Synonyms=ube2cbp {ECO:0000313|RefSeq:NP_001313339.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:NP_001313339.1}; RN [1] {ECO:0000313|RefSeq:NP_001313339.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001313339.1}; RX PubMed=12477932; DOI=10.1073/pnas.242603899; RG Mammalian Gene Collection Program Team; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K., RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F., RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S., RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J., RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J., RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M., RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C., RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I., RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human and RT mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] {ECO:0000313|RefSeq:NP_001313339.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001313339.1}; RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [3] {ECO:0000313|RefSeq:NP_001313339.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001313339.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from CC specific E2 ubiquitin-conjugating enzymes, and transfers it to CC substrates, generally promoting their degradation by the proteasome. CC {ECO:0000256|ARBA:ARBA00003573}. CC -!- CATALYTIC ACTIVITY: CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001313339.1; NM_001326410.1. DR GeneID; 553294; -. DR Proteomes; UP000000437; Chromosome 16. DR InterPro; IPR019193; UBQ-conj_enz_E2-bd_prot. DR PANTHER; PTHR31531; PTHR31531; 1. DR Pfam; PF09814; HECT_2; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. SQ SEQUENCE 388 AA; 43030 MW; D8EB1C48BEEF5B5B CRC64; MEETANTDVL FIELRQKLQS GLLFIRSDVI GGGADVKIES KPDSILNVQT PDSSFQVTLT PGVSLVETQK QKSPANSEQG SHYRLRLKVE QPTESPCSVI GQLRVDESYS VLCQSCGSRV LQHRSFGRVL PLPNGNWNAL VDDWCCHPDP FANRKLLPRA GDCLLGDTFI LLLRDDGCDE SLTRAAAEKR VLVSCRRCST ALGEEITAEV LKLYITEISV KPSEDGECDL TQLSLEPKSE SVRQRFLEQT LASRLVELSA AQSIFRFSIQ SPDGKAEILL WLLNTDTLVA SFPAPAARAD GFISVGDSHP RMHQSCQAVA AVKVLYILCS DSKLRDVVDV WEKDISVHPL PLPQRSCEEL KTLLTSSTFR LPAFLRCMNS FQVAYMRM //