ID A0A8M1NFQ8_DANRE Unreviewed; 662 AA. AC A0A8M1NFQ8; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 14-DEC-2022, entry version 3. DE RecName: Full=Centrosomal protein of 76 kDa {ECO:0000256|ARBA:ARBA00015706}; GN Name=cep76 {ECO:0000313|RefSeq:NP_001096589.2}; GN Synonyms=zgc:162328 {ECO:0000313|RefSeq:NP_001096589.2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:NP_001096589.2}; RN [1] {ECO:0000313|RefSeq:NP_001096589.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001096589.2}; RX PubMed=18950740; DOI=10.1016/j.ajhg.2008.10.002; RA Gorden N.T., Arts H.H., Parisi M.A., Coene K.L., Letteboer S.J., RA van Beersum S.E., Mans D.A., Hikida A., Eckert M., Knutzen D., RA Alswaid A.F., Ozyurek H., Dibooglu S., Otto E.A., Liu Y., Davis E.E., RA Hutter C.M., Bammler T.K., Farin F.M., Dorschner M., Topcu M., Zackai E.H., RA Rosenthal P., Owens K.N., Katsanis N., Vincent J.B., Hildebrandt F., RA Rubel E.W., Raible D.W., Knoers N.V., Chance P.F., Roepman R., Moens C.B., RA Glass I.A., Doherty D.; RT "CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy- RT associated basal body protein CEP290."; RL Am. J. Hum. Genet. 83:559-571(2008). RN [2] {ECO:0000313|RefSeq:NP_001096589.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001096589.2}; RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [3] {ECO:0000313|RefSeq:NP_001096589.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001096589.2}; RX PubMed=27189481; RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I., RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y., RA Bobe J.; RT "Gene evolution and gene expression after whole genome duplication in fish: RT the PhyloFish database."; RL BMC Genomics 17:368-368(2016). RN [4] {ECO:0000313|RefSeq:NP_001096589.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001096589.2}; RX PubMed=27903883; RA Shim H., Kim J.H., Kim C.Y., Hwang S., Kim H., Yang S., Lee J.E., Lee I.; RT "Function-driven discovery of disease genes in zebrafish using an RT integrated genomics big data resource."; RL Nucleic Acids Res. 44:9611-9623(2016). RN [5] {ECO:0000313|RefSeq:NP_001096589.2} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001096589.2}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- FUNCTION: Centrosomal protein involved in regulation of centriole CC duplication. Required to limit centriole duplication to once per cell CC cycle by preventing centriole reduplication. CC {ECO:0000256|ARBA:ARBA00024729}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing CC center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}. CC -!- SIMILARITY: Belongs to the CEP76 family. CC {ECO:0000256|ARBA:ARBA00005400}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001096589.2; NM_001103119.2. DR GeneID; 564926; -. DR KEGG; dre:564926; -. DR Proteomes; UP000000437; Chromosome 16. DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR InterPro; IPR028926; CEP76-C2. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR Pfam; PF15627; CEP76-C2; 1. DR SUPFAM; SSF54001; Cysteine proteinases; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 108..259 FT /note="CEP76-C2" FT /evidence="ECO:0000259|Pfam:PF15627" SQ SEQUENCE 662 AA; 74348 MW; 2811DBE387E63510 CRC64; MSLSPEKANE LKQIIHDHLI KMDIHGKIRD VLTETVQGDG HHKQCLLSEE DFMHALQRRG IVNDVMKDLH FTNMYNSHTE ADSVNKSATH FMDQNITQLK TANIGQLKRQ LYLQVVGGKA FLEQLQEPEP LPGQVCSTFT LHVHFRNQRF RSKPIPCACE PDIQEGFLLE IHRDGPGDAS KMADATTMLS ICDPVHMVLI KTDTSGDTTL VSSYFLDWRT VLSAPNGKIS VSAELLGVGA EAKVPAGVLN LKLELYPPLT ETLSPDVVTM QKSLERQKTA EKERLFLVYA KQWWQEFLDI RPSNKSKLVK IFAQDENGVN RPVCSYVRVL RAGRLLESPR QAARFVSLLA QERAPVVGGG VRQEQWASMM VFLCRNKGDC EDHATLLCSL LLGFGLDAYV CVGTKVKNIP HTWVMTCGTD GSITFWESFT AHRYLHRPID PDAPSMILQP KPVHPYQTLG CVFNHKIFLA NCQVSDAVER CVFDFTDGSR WKAMSEEAVR SVCDPGFNAS LPPTPPLCSS SLVPNEASNQ LELEMRYLLS EHRKDLGLAT VWDDHLSYLL SAALSAYELE RCAGVSYGNE EFQDAVRRAV PDGHTFKAFP INFLHCNARR AFATCLRSPF CEEIVCCRGD HVRLAVRVRV FGYPESACAV WIMFACKYRS VL //