ID A0A8K1H2F1_9TELE Unreviewed; 116 AA. AC A0A8K1H2F1; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 29-MAY-2024, entry version 8. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003640}; GN Name=ND3 {ECO:0000313|EMBL:UBD04593.1}; OS Sillago ingenuua (bay sillago). OG Mitochondrion {ECO:0000313|EMBL:UBD04593.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sillaginidae; Sillago. OX NCBI_TaxID=443724 {ECO:0000313|EMBL:UBD04593.1}; RN [1] {ECO:0000313|EMBL:UBD04593.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A {ECO:0000313|EMBL:UBD04593.1}, and B RC {ECO:0000313|EMBL:UBD04606.1}; RG Fisheries College; RG Ocean University of China; RA Xiao J., Song N., Gao T.; RT "Comparative mitogenomics to discriminate sibling species within a RT morphologically difficult fish Sillago ingenuua (Perciformes: RT Sillaginidae)."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity of complex I. CC {ECO:0000256|RuleBase:RU003640}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003640}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003640}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MF958502; UBD04593.1; -; Genomic_DNA. DR EMBL; MF958503; UBD04606.1; -; Genomic_DNA. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:TreeGrafter. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1. DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003640}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:UBD04593.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640}; KW Respiratory chain {ECO:0000256|RuleBase:RU003640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003640}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003640}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..116 FT /note="NADH-ubiquinone oxidoreductase chain 3" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5035416210" FT TRANSMEM 52..74 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" FT TRANSMEM 86..108 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" SQ SEQUENCE 116 AA; 13108 MW; D7870695621761DD CRC64; MNLVTTIIMI AILLSTVLAI VSFWLPQMTP DHEKLSPYEC GFDPLGSARL PFSLRFFLVA ILFLLFDLEI ALLLPLPWGD QLPSPIFTFI WASTVLVLLT LGLIYEWLQG GLEWAE //