ID A0A8J0QFI3_XENLA Unreviewed; 153 AA. AC A0A8J0QFI3; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 22-FEB-2023, entry version 5. DE SubName: Full=selenoprotein F L homeolog precursor {ECO:0000313|RefSeq:NP_001165183.1}; DE Flags: Precursor; GN Name=selenof.L {ECO:0000313|RefSeq:NP_001165183.1}; GN Synonyms=selenof {ECO:0000313|RefSeq:NP_001165183.1}, sep15 GN {ECO:0000313|RefSeq:NP_001165183.1}, sep15.L GN {ECO:0000313|RefSeq:NP_001165183.1}; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:NP_001165183.1}; RN [1] {ECO:0000313|RefSeq:NP_001165183.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12454917; DOI=10.1002/dvdy.10174; RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W., RA Richardson P.; RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus RT initiative."; RL Dev. Dyn. 225:384-391(2002). RN [2] {ECO:0000313|RefSeq:NP_001165183.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22479358; RA Mariotti M., Ridge P.G., Zhang Y., Lobanov A.V., Pringle T.H., Guigo R., RA Hatfield D.L., Gladyshev V.N.; RT "Composition and evolution of the vertebrate and mammalian RT selenoproteomes."; RL PLoS ONE 7:E33066-E33066(2012). RN [3] {ECO:0000313|RefSeq:NP_001165183.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27645994; DOI=10.1074/jbc.M116.756155; RA Gladyshev V.N., Arner E.S., Berry M.J., Brigelius-Flohe R., Bruford E.A., RA Burk R.F., Carlson B.A., Castellano S., Chavatte L., Conrad M., RA Copeland P.R., Diamond A.M., Driscoll D.M., Ferreiro A., Flohe L., RA Green F.R., Guigo R., Handy D.E., Hatfield D.L., Hesketh J., Hoffmann P.R., RA Holmgren A., Hondal R.J., Howard M.T., Huang K., Kim H.Y., Kim I.Y., RA Kohrle J., Krol A., Kryukov G.V., Lee B.J., Lee B.C., Lei X.G., Liu Q., RA Lescure A., Lobanov A.V., Loscalzo J., Maiorino M., Mariotti M., RA Sandeep Prabhu K., Rayman M.P., Rozovsky S., Salinas G., Schmidt E.E., RA Schomburg L., Schweizer U., Simonovic M., Sunde R.A., Tsuji P.A., RA Tweedie S., Ursini F., Whanger P.D., Zhang Y.; RT "Selenoprotein gene nomenclature."; RL J. Biol. Chem. 291:24036-24040(2016). RN [4] {ECO:0000313|RefSeq:NP_001165183.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SIMILARITY: Belongs to the selenoprotein M/F family. CC {ECO:0000256|ARBA:ARBA00005742}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001165183.1; NM_001171712.2. DR GeneID; 495210; -. DR KEGG; xla:495210; -. DR CTD; 495210; -. DR Proteomes; UP000186698; Chromosome 4L. DR Gene3D; 3.40.30.50; Sep15/SelM thioredoxin-like domain, active-site redox motif; 1. DR InterPro; IPR038219; Sep15/SelM_sf. DR InterPro; IPR039992; Sep15_SelM. DR InterPro; IPR014912; Sep15_SelM_dom. DR InterPro; IPR036249; Thioredoxin-like_sf. DR PANTHER; PTHR13077; SELENOPROTEIN F; 1. DR PANTHER; PTHR13077:SF6; SELENOPROTEIN F; 1. DR Pfam; PF08806; Sep15_SelM; 1. DR SUPFAM; SSF52833; Thioredoxin-like; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000186698}; KW Selenium {ECO:0000313|RefSeq:NP_001165183.1}; KW Selenocysteine {ECO:0000256|ARBA:ARBA00022933, KW ECO:0000313|RefSeq:NP_001165183.1}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..18 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001165183.1" FT CHAIN 19..153 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001165183.1" FT /id="PRO_5033207676" FT DOMAIN 76..150 FT /note="Selenoprotein F/M" FT /evidence="ECO:0000259|Pfam:PF08806" FT NON_STD 84 FT /note="Selenocysteine" FT /evidence="ECO:0000313|RefSeq:NP_001165183.1" SQ SEQUENCE 153 AA; 17201 MW; 605EFF5F82E4F3F6 CRC64; MAAERMLLWL VAVLQALASY GAELSSEACR DLGFSSNLLC SSCDLLGQFG LNEINSFCRQ CCQEEVHLES KKRYPGAVLE ICGUKLGRFP QVQAFVRSEK PKLFKGLQIK YVRGSDPVLK LLDENGNISE ELSILKWNTD SVEEFLSEKL DRV //