ID A0A8I6AWB8_RAT Unreviewed; 822 AA. AC A0A8I6AWB8; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 08-NOV-2023, entry version 9. DE SubName: Full=Potassium voltage-gated channel subfamily Q member 5 {ECO:0000313|Ensembl:ENSRNOP00000097404.1}; GN Name=Kcnq5 {ECO:0000313|Ensembl:ENSRNOP00000097404.1, GN ECO:0000313|RGD:628848}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000097404.1, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000097404.1, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000097404.1, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000097404.1} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000097404.1}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSRNOT00000098049.1; ENSRNOP00000097404.1; ENSRNOG00000013781.9. DR AGR; RGD:628848; -. DR RGD; 628848; Kcnq5. DR GeneTree; ENSGT00940000155933; -. DR Proteomes; UP000002494; Chromosome 9. DR GO; GO:0044305; C:calyx of Held; IDA:SynGO. DR GO; GO:0030118; C:clathrin coat; ISO:RGD. DR GO; GO:0005886; C:plasma membrane; ISO:RGD. DR GO; GO:0042734; C:presynaptic membrane; IDA:SynGO. DR GO; GO:0008076; C:voltage-gated potassium channel complex; ISO:RGD. DR GO; GO:0099508; F:voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; IDA:SynGO. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IMP:RGD. DR GO; GO:0071805; P:potassium ion transmembrane transport; ISO:RGD. DR GO; GO:0006813; P:potassium ion transport; IMP:RGD. DR Gene3D; 1.10.287.70; -; 1. DR Gene3D; 6.10.140.1910; -; 1. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ. DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C. DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1. DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF03520; KCNQ_channel; 1. DR PRINTS; PR00169; KCHANNEL. DR PRINTS; PR01459; KCNQCHANNEL. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1. PE 4: Predicted; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023303}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|ARBA:ARBA00022958}; KW Potassium channel {ECO:0000256|ARBA:ARBA00022826}; KW Potassium transport {ECO:0000256|ARBA:ARBA00022538}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}. FT TRANSMEM 126..148 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 154..179 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 200..218 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 268..286 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 325..351 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 129..351 FT /note="Ion transport" FT /evidence="ECO:0000259|Pfam:PF00520" FT DOMAIN 413..524 FT /note="Potassium channel voltage dependent KCNQ C-terminal" FT /evidence="ECO:0000259|Pfam:PF03520" FT REGION 767..822 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 791..810 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 822 AA; 90103 MW; E63CFAC16766063E CRC64; MPRHHAGGEE GGAAGLWVRS GAAAAAGGGR PGSGMKDVES GRGRVLLNSA AARGDGLLLL GTRAAALGGG GGGLRESRRG KQGARMSLLG KPLSYTSSQS CRRNVKYRRV QNYLYNVLER PRGWAFVYHA FVFLLVFGCL ILSVFSTIPE HTKLASSCLL ILEFVMIVVF GLEFIIRIWS AGCCCRYRGW QGRLRFARKP FCVIDTIVLI ASIAVVSAKT QGNIFATSAL RSLRFLQILR MVRMDRRGGT WKLLGSVVYA HSKELITAWY IGFLVLIFSS FLVYLVEKDA NKEFSTYADA LWWGTITLTT IGYGDKTPLT WLGRLLSAGF ALLGISFFAL PAGILGSGFA LKVQEQHRQK HFEKRRNPAA NLIQCVWRSY AADEKSVSIA TWKPHLKALH TCSPTKKEQG EAASRIMKFH VAKRKFKETL RPYDVKDVIE QYSAGHLDML CRIKSLQTRV DQILGKGQIT SDKKSREKIT AEHETTTDDL SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALT LTSFQIPPFE CEQTSDYQSP VESKDLSSSA QNSGCLSRSA SANISRGLQF ILTPNEFSAQ TFYALSPTMH SQTTQVPMSQ NDGSSVVATN NLANQISAAP KPAAPTTLQI PPPLSAIKHL SRPEPLLSNP PGVHESISDV TTCLVASKEN VQFAQSNLTK DRSLRKSFDM GGETLLSVRP MVPKDLGKSL SVQNLIRSTE ELNLQFSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGAEE TETDTFDGTP PPAGEAAFSS DSLRTGRSRS SQNICKTGDS TDALSLPHVK LN //