ID A0A8I6A868_RAT Unreviewed; 356 AA. AC A0A8I6A868; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 28-JUN-2023, entry version 7. DE RecName: Full=NIF3-like protein 1 {ECO:0000256|ARBA:ARBA00019069, ECO:0000256|PIRNR:PIRNR037490}; GN Name=Nif3l1 {ECO:0000313|Ensembl:ENSRNOP00000089215.1, GN ECO:0000313|RGD:1310329}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000089215.1, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000089215.1, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000089215.1, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000089215.1} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000089215.1}; RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC -!- FUNCTION: May function as a transcriptional corepressor through its CC interaction with COPS2, negatively regulating the expression of genes CC involved in neuronal differentiation. {ECO:0000256|PIRNR:PIRNR037490}. CC -!- SUBUNIT: Homodimer. Interacts with COPS2. Interacts with THOC7. CC {ECO:0000256|PIRNR:PIRNR037490}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037490}. CC Nucleus {ECO:0000256|PIRNR:PIRNR037490}. CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase I type 2/NIF3 family. CC {ECO:0000256|ARBA:ARBA00006964, ECO:0000256|PIRNR:PIRNR037490}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSRNOT00000119712.1; ENSRNOP00000089215.1; ENSRNOG00000013446.8. DR RGD; 1310329; Nif3l1. DR GeneTree; ENSGT00390000003590; -. DR Proteomes; UP000002494; Chromosome 9. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR Gene3D; 3.40.1390.30; NIF3 (NGG1p interacting factor 3)-like; 2. DR InterPro; IPR002678; DUF34/NIF3. DR InterPro; IPR017222; DUF34/NIF3_animal. DR InterPro; IPR036069; DUF34/NIF3_sf. DR PANTHER; PTHR13799; NGG1 INTERACTING FACTOR 3; 1. DR PANTHER; PTHR13799:SF13; NIF3-LIKE PROTEIN 1; 1. DR Pfam; PF01784; NIF3; 2. DR PIRSF; PIRSF037490; UCP037490_NIF3_euk; 2. DR SUPFAM; SSF102705; NIF3 (NGG1p interacting factor 3)-like; 1. PE 1: Evidence at protein level; KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037490}; KW Nucleus {ECO:0000256|PIRNR:PIRNR037490}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A8I6A868}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. SQ SEQUENCE 356 AA; 39526 MW; 9D43F149F4743DAF CRC64; MLSSAHVVPT SVRRAPSWIC SSSRSFMDLK ALLSSLNDFA SLSFAESWDN VGLLVEPSPP HTVNTLFLTN DLTEEVMEEA LQKKADLILS YHPPIFRPMK HITWKTWKER LVIRALENRV AIYSPHTAYD AAPQGVNSWL AKGLGTCTTR PIHPSKAPNY PTEGTHRLEF SANHSQDLDK VMSAVKGVGG VSVTSFPARC DGEEQTRVSL NCTQKALMQV LAFLSQDRQL YQKTEILSLE KPLLLHTGMG RLCTLDESVS LATMIERIKR HLKLPHLRLA LGVGRTLGCS GSESDSEMSH HDVLDAASKG INVILCEHSN TERGFLSDLQ EMLGVHLENK INIILSETDR DPLRVV //