ID A0A8I5ZUG3_RAT Unreviewed; 1252 AA. AC A0A8I5ZUG3; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 13-SEP-2023, entry version 8. DE SubName: Full=Adhesion G protein-coupled receptor A2 {ECO:0000313|Ensembl:ENSRNOP00000082075.1}; GN Name=Adgra2 {ECO:0000313|Ensembl:ENSRNOP00000082075.1, GN ECO:0000313|RGD:2323365}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000082075.1, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000082075.1, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000082075.1, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000082075.1} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000082075.1}; RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC Adhesion G-protein coupled receptor (ADGR) subfamily. CC {ECO:0000256|ARBA:ARBA00007343}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSRNOT00000095677.1; ENSRNOP00000082075.1; ENSRNOG00000012991.6. DR AGR; RGD:2323365; -. DR RGD; 2323365; Adgra2. DR GeneTree; ENSGT00940000158941; -. DR Proteomes; UP000002494; Chromosome 16. DR GO; GO:0009986; C:cell surface; ISO:RGD. DR GO; GO:0005886; C:plasma membrane; ISO:RGD. DR GO; GO:1990909; C:Wnt signalosome; ISO:RGD. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro. DR GO; GO:0001525; P:angiogenesis; ISO:RGD. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007417; P:central nervous system development; ISO:RGD. DR GO; GO:0043542; P:endothelial cell migration; ISO:RGD. DR GO; GO:1900747; P:negative regulation of vascular endothelial growth factor signaling pathway; ISO:RGD. DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD. DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISO:RGD. DR GO; GO:0045765; P:regulation of angiogenesis; ISO:RGD. DR GO; GO:0050920; P:regulation of chemotaxis; ISO:RGD. DR GO; GO:0090210; P:regulation of establishment of blood-brain barrier; ISO:RGD. DR GO; GO:0002040; P:sprouting angiogenesis; ISO:RGD. DR Gene3D; 2.60.220.50; -; 1. DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR046338; GAIN_dom_sf. DR InterPro; IPR017981; GPCR_2-like_TM. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR000203; GPS. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1. DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF01825; GPS; 1. DR Pfam; PF13855; LRR_8; 1. DR SMART; SM00303; GPS; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00369; LRR_TYP; 4. DR SMART; SM00082; LRRCT; 1. DR SUPFAM; SSF111418; Hormone receptor domain; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF52058; L domain-like; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. DR PROSITE; PS50221; GPS; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS51450; LRR; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 811..832 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 844..864 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 926..946 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 966..989 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1031..1049 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 302..386 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 369..463 FT /note="G-protein coupled receptors family 2 profile 1" FT /evidence="ECO:0000259|PROSITE:PS50227" FT DOMAIN 749..797 FT /note="GPS" FT /evidence="ECO:0000259|PROSITE:PS50221" FT DOMAIN 808..983 FT /note="G-protein coupled receptors family 2 profile 2" FT /evidence="ECO:0000259|PROSITE:PS50261" FT REGION 1..47 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1064..1226 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1083..1100 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1125..1149 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1252 AA; 135012 MW; F36FE239824391D8 CRC64; MAPRPALGRP GLPLSTPLAR SGPSSRRTVR PLRCRSPRGD GLMGAGGRRM PVRSARLLLL PLLPCLLLLA PGTRGAPGCP VPIRGCKCSG ERPKGLSGGA HNPARRRVVC GGGDLPEPPD PGLLPNGTIT LLLSNNKITG LRNGSFLGLS LLEKLDLRSN VISTVQPGAF LGLGELKRLD LSNNRIGCLT SETFQGLPRL LRLNISGNIY SSLQPGVFDE LPDLKIVDFG TEFLTCDCRL RWLLPWARNH SLQLSERTLC AYPSALHAHA LSSLQESQLR CEGALELHTH YLIPSLRQVV FQGDRLPFQC SASYLGNDTQ IHWYHNGAPM ESDEQAGIVL AENLIHDCTF ITSELTLSHI GVWASGEWEC SVSTVQGNTS KKVEIVVLET SASYCPAERV TNNRGDFRWP RTLAGITAYQ SCLQYPFTSV PLSGGAPGTR ASRRCDRAGR WEPGDYSHCL YTNDITRVLY TFVLMPINAS NALTLAHQLR VYTAEAASFS DMMDVVYVAQ MIQKFLGYVD QIKELVEVMV DMASNLMLVD EHLLWLAQRE DKACSGIVGA LERIGGAALS PHAQHISVNS RNVALEAYLI KPHSYVGLTC TAFQRREVGV SGVQPSSPGQ DVPLEPEALA DQQLRFRCTT GRPNVSLSSF HIKNSVALAS IQLPPSLFST LPAALAPPVP PDCTLQLLVF RNGRLFRSHG NTSRPGTAEP SKRRGVATPV IFAGTSGCGV GNLTEPVAVS LRHWAEGTDP LAAWWNQDGP GGWSSEGCKL RFSQPNVSSL YCQHLGNVAV LMELSAFPRE AGGSGAGLHP VVYPCTALLL LCLFSTIITY ILNHSSIHVS RKGWHMLLNL CFHMAMTSAV FVGGVTLTNY QMVCQAVGIT LHYSSLSSLL WMGVKARVLH KELSWRAPPP EEGEAAPPGP RPMLRFYLIA GGIPLIICGI TAAVNIHNYR DHSPYCWLVW RPSLGAFYIP VALILPITWI YFLCAGLHLR GHVAQNPKQV SAGVGTPAPP EESDGVYSPG VQLGALMTTH FLYLAMWACG ALAVSQRWLP RVVAQSQVCE ASMVARGDGE PEPTGSRSSL APRHHNNLHH GRRVHKSRAK GHRAGETGGK SRLKALRAGT SPGAPELLSS ESGSLHNSPS DSYPGSSRNS PGDGLPLEGE PMLTPSEGSD TSAAQIPETG RPGQRRSASR DNLKGSGSAL ERESKRRSYP LNTTSLNGAP KGGKYEDASV TGAEAIAGGC MKTGLWKSET TV //