ID A0A8I5ZL69_RAT Unreviewed; 326 AA. AC A0A8I5ZL69; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 27-NOV-2024, entry version 15. DE RecName: Full=Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 {ECO:0000256|ARBA:ARBA00033769}; GN Name=Cstpp1 {ECO:0000313|Ensembl:ENSRNOP00000078631.1, GN ECO:0000313|RGD:1309540}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000078631.1, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000078631.1, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000078631.1, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000078631.1} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000078631.1}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- FUNCTION: Regulator of the tubulin polyglutamylase complex (TPGC) that CC controls cytoskeletal organization, nuclear shape, and cilium CC disassembly by balancing microtubule and actin assembly. Regulates the CC assembly and stability of the TPGC and thereby modulates CC polyglutamylation of the microtubule, which antagonizes MAP4 binding. CC {ECO:0000256|ARBA:ARBA00045673}. CC -!- SUBUNIT: Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and CC LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to CC alpha-tubulin. {ECO:0000256|ARBA:ARBA00046566}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing CC center, centrosome, centriolar satellite CC {ECO:0000256|ARBA:ARBA00004607}. CC -!- SIMILARITY: Belongs to the CSTPP1 family. CC {ECO:0000256|ARBA:ARBA00033750}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_017447045.1; XM_017591556.1. DR Ensembl; ENSRNOT00000108550.1; ENSRNOP00000078631.1; ENSRNOG00000014798.7. DR GeneID; 295930; -. DR CTD; 79096; -. DR RGD; 1309540; Cstpp1. DR GeneTree; ENSGT00390000012935; -. DR Proteomes; UP000002494; Chromosome 3. DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. DR CDD; cd22959; DD_C11orf49; 1. DR InterPro; IPR038968; CSTPP1. DR PANTHER; PTHR34252:SF1; CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1; 1. DR PANTHER; PTHR34252; UPF0705 PROTEIN C11ORF49; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}; KW Microtubule {ECO:0000256|ARBA:ARBA00022701}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT REGION 283..326 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 326 AA; 37503 MW; E9E33C8A7E691051 CRC64; MLSPERLALP DYEYLAQRHV LTYMEDAVCQ LLENKEDISQ YGIARFFTEY FNSVCQGTHI LFREFSFIQA TPHNRASFLR AFWRCFRTVG KNGDLLTMRE YHCLLQLLCP DFPLELTQKA ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS EFLESVAAIY QDLLSGKNPN TVIVPTSSSG QHRQRPALGD AGMLDGVEAS LFCQRLENLC DRHKYSCPPP ALVKEILSNV QRLTFYGFLV ALSKHHGINQ ALGALPDKGD LMHDPAMDEE LERLVVRSRL YRTPRQQRGK EPGAFGFQRR DKLEAPERVP SALAPTPNPY RWEPRE //