ID A0A8I5ZKA2_RAT Unreviewed; 1914 AA. AC A0A8I5ZKA2; DT 25-MAY-2022, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 1. DT 12-OCT-2022, entry version 3. DE SubName: Full=Thyroid hormone receptor interactor 11 {ECO:0000313|Ensembl:ENSRNOP00000077357}; GN Name=Trip11 {ECO:0000313|Ensembl:ENSRNOP00000077357, GN ECO:0000313|RGD:1586166}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000077357, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000077357, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000077357, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000077357} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000077357}; RG Ensembl; RL Submitted (JAN-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSRNOT00000096337.1; ENSRNOP00000077357.1; ENSRNOG00000005292.8. DR RGD; 1586166; Trip11. DR GeneTree; ENSGT00710000106769; -. DR Proteomes; UP000002494; Chromosome 6. DR GO; GO:0002080; C:acrosomal membrane; ISO:RGD. DR GO; GO:0005801; C:cis-Golgi network; ISO:RGD. DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:RGD. DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central. DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central. DR GO; GO:0060348; P:bone development; ISO:RGD. DR GO; GO:0051216; P:cartilage development; ISO:RGD. DR GO; GO:0003413; P:chondrocyte differentiation involved in endochondral bone morphogenesis; ISO:RGD. DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central. DR GO; GO:0007030; P:Golgi organization; ISO:RGD. DR GO; GO:0090161; P:Golgi ribbon formation; ISO:RGD. DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; ISO:RGD. DR GO; GO:0006486; P:protein glycosylation; ISO:RGD. DR GO; GO:0003281; P:ventricular septum development; ISO:RGD. DR GO; GO:0099041; P:vesicle tethering to Golgi; ISO:RGD. DR InterPro; IPR000237; GRIP_dom. DR PROSITE; PS50913; GRIP; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A8I5ZKA2}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 1734..1783 FT /note="GRIP" FT /evidence="ECO:0000259|PROSITE:PS50913" FT REGION 43..66 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 586..605 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 809..854 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1274..1302 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1324..1356 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 242..361 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 985..1012 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1086..1139 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1164..1219 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1513..1618 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1648..1727 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 586..602 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 809..837 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1338..1356 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1914 AA; 219206 MW; 0E4424EF93122272 CRC64; MSSWLGGLGS GLGQSLGQVG GSLASLTGQI SNFTKDMLME GTEDVPADLP NSGREENGAT HSVLRSENER LKKLYTDLEE KHEASELQIK QQSSSYRSQL QQKEEEINHL KARQTALQDE LLRLQVAAQS AHSGAATAPA ATAPASFSYG ISHPVSAFHE DDMDFGDVIS SQQEINRLSN EVSRLESELG HWRHIAQVQG AQSSDQTEIC KLQNIIKELK QNRSQEIDDH QHEMSVLQNA HQQKLTEISR RHREELRDYE ERIEELENLL QQGGSGVTVT DHSKVYEMQN TIQSLQMERV ESSRKIEDLE NKIKEIHKRL SSAEHDREVC KKEQERLEME KRQMAEQCER LKLDCREAQQ SALRLTDAVT EDERSLSQSA SVAEVLRLQL LSCKLNILQE KEELQTSLSR LSHEYEVIKS TATRDSDLSS QVHDLKHNLE AKEQELNQSI HENEILMAEL EELDKQNQEA TKHVILIKEQ LSKQQSEGDS VIKRLKEELD DEKKRTHQLE DDKMNIIKEL NVQKEKLTHS EQVLSDLQLT KQKLEGKVED LVDQLSKSEK NNFDIQKENR ELREHIRQNE EELSTVRSEL TQSQTQGSNS NLKDDLLREK ETEVQSLKQN LSEIEQLNEH LKQVAFDLRI ENEKLVVACE DVRNQLEESV AGNNQISLEK AAILEWEKAQ LEAEPCRAEK RLLEEGRKYR QTVQGPSSTH SPDASALQLE QERLIQLNQE KDFEIAELKK SIEQMDTDHK QTKETLSSSL EEQKQLAQLI NEKEICIVKL KEKSSELQRE LDRCSQALRK NETLRQTIEE KDRSLGSMKE ENNHLQEELE RLREQQSRAV PVPEPRTLDS TTELESELSQ LHTIKDHLEE EIKHHQKMIE DQNQNKMQLL QSLQEQKKAM DEFKYQHEQM SITHSRLFLE KDEEIKNLQK TIEQIKAQLQ EERQDSQTEN SDIFQETKVQ SLNIEIGSEK HDLSKAETER LVKGIKEREL EIKLLNEKNI SLTKQIDQLS KDEVGKLTQI IQQKDVEIQA LHARISSASY SQDVVYLQQQ VQAYAMEREK VMVVLSEKTR ENSKLKSEYH KMIDILSAKE AALIKLQDEN KKMSTRFESS GQDMFKETIQ NLSRIIREKD IEIDALSQKC QTLLTVLQTS GTGSEVGGVN SNQFEELLQE RDKLKQQVKK MEEWKQQVMT TVQNMQHESA QLQEELHQLQ AQVSVDSDNN TKLQVNYTGL IQSYEQNETK LKNFGQELAQ VQHSIGQLCT TKDLLLGKLD SMSPQLSPGS SLTTQAAEPL KASQCSGPHE SSHLLQQEVD DLRKSLQEKD ATIRTLQENN HRLSDSMAAS SEGERKEHEQ TDSEVKQLKE KQEVLQNLLK EKDLLIKAKS DQLHSSNENF ANKVSENELL RQAVTNLKER ILILEMDISK LKGENEKVIE ASKGKETEYQ ALQETNMKFS MMLREKEFEC HSMREKALAF EQLLKEKEQG KAGELNQLLN AVKSMQEKTV TFQQERDQVM LALKQKQMET STLQNEVQRL RDKEARLNQE LQRLRDHLLE SEDSHTREAL AAEDREAKLR KKVSVLEEKL VSSSNAMENA SHQASVQVES LQEQLNMVSK QRDETALQLS VSQEQVKQYA MSLTNLQMVL EHFQQEEKAM YSAELEKQNQ LLTEWKKKAE SLEGKVLSLQ ERLDEANAAL DSASRLTEQL DLKEEQIEEL KKQNELHQEM LDDAQKKLMS LVNSTEGKVD KVLMRNLFIG HFHTPKNQRH EVLRLMGSIL GVKREEMEQL FAEDQGGVTR WMAGWLGGGS KSVPNTPLRP NQQSVFNSVR PTEGHPQLLG VHEGKSLSYL LDTAESRAGR RTDMNPFLAP RSAAVPLINP AGHGPGGPGH LLLKPISDVL PTFTPLPVSP DNSAGVVLKD LLKQ //