ID   A0A8I5KV47_HUMAN        Unreviewed;       155 AA.
AC   A0A8I5KV47;
DT   25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 1.
DT   29-MAY-2024, entry version 12.
DE   SubName: Full=Exosome component 2 {ECO:0000313|Ensembl:ENSP00000509176.1};
GN   Name=EXOSC2 {ECO:0000313|Ensembl:ENSP00000509176.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000509176.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000509176.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000509176.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2024) to UniProtKB.
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DR   EMBL; AL359092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; A0A8I5KV47; -.
DR   PeptideAtlas; A0A8I5KV47; -.
DR   Ensembl; ENST00000688258.1; ENSP00000509176.1; ENSG00000130713.17.
DR   HGNC; HGNC:17097; EXOSC2.
DR   GeneTree; ENSGT00940000153596; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:TreeGrafter.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:TreeGrafter.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0071034; P:CUT catabolic process; IEA:TreeGrafter.
DR   GO; GO:0043928; P:exonucleolytic catabolism of deadenylated mRNA; IEA:TreeGrafter.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:TreeGrafter.
DR   GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IEA:TreeGrafter.
DR   GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:TreeGrafter.
DR   GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IEA:TreeGrafter.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IEA:TreeGrafter.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IEA:TreeGrafter.
DR   CDD; cd05789; S1_Rrp4; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR025721; Exosome_cplx_N_dom.
DR   InterPro; IPR026699; Exosome_RNA_bind1/RRP40/RRP4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR048565; RRP4_S1.
DR   PANTHER; PTHR21321:SF4; EXOSOME COMPLEX COMPONENT RRP4; 1.
DR   PANTHER; PTHR21321; PNAS-3 RELATED; 1.
DR   Pfam; PF14382; ECR1_N; 1.
DR   Pfam; PF21266; RRP4_S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF110324; Ribosomal L27 protein-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:A0A8I5KV47,
KW   ECO:0007829|MaxQB:A0A8I5KV47};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          26..63
FT                   /note="Exosome complex component N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14382"
FT   DOMAIN          75..142
FT                   /note="RRP4 S1"
FT                   /evidence="ECO:0000259|Pfam:PF21266"
SQ   SEQUENCE   155 AA;  17007 MW;  A4A3DFFA2DD409AD CRC64;
     MAMEMRLPVA RKPLSERLGR DTKKHLVVPG DTITTDTGFM RGHGTYMGEE KLIASVAGSV
     ERVNKLICVK ALKTRYIGEV GDIVVGRITE VQQKRWKVET NSRLDSVLLL SSMNLPGGEL
     RRRSAEDELA MRGFLQEGDL ISDGQGSQGH GSVAL
//