ID A0A8F0ZWG1_9BETC Unreviewed; 7081 AA. AC A0A8F0ZWG1; DT 19-JAN-2022, integrated into UniProtKB/TrEMBL. DT 19-JAN-2022, sequence version 1. DT 27-MAR-2024, entry version 12. DE RecName: Full=ORF1ab polyprotein {ECO:0000256|PROSITE-ProRule:PRU01344}; GN Name=ORF1ab {ECO:0000313|EMBL:QWN56221.1}; OS Betacoronavirus sp. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus. OX NCBI_TaxID=1928434 {ECO:0000313|EMBL:QWN56221.1}; RN [1] {ECO:0000313|EMBL:QWN56221.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bat/Yunnan/RmYN08/2020 {ECO:0000313|EMBL:QWN56221.1}; RA Zhou H., Ji J., Chen X., Bi Y., Li J., Wang Q., Hu T., Song H., Zhao R., RA Chen Y., Cui M., Zhang Y., Hughes A.C., Holmes E.C., Shi W.; RT "Identification of novel bat coronaviruses sheds light on the evolutionary RT origins of SARS-CoV-2 and related viruses."; RL Cell 0:0-0(2021). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|ARBA:ARBA00001556}; CC -!- CATALYTIC ACTIVITY: CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- CC residue protein attached to proteins as an intracellular targeting CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside CC in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- CC triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S- CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:67020, Rhea:RHEA-COMP:17167, CC Rhea:RHEA-COMP:17168, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167609; CC EC=2.1.1.57; Evidence={ECO:0000256|ARBA:ARBA00024256}; CC -!- CATALYTIC ACTIVITY: CC Reaction=uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl- CC 2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside- CC RNA; Xref=Rhea:RHEA:67732, Rhea:RHEA-COMP:13936, Rhea:RHEA- CC COMP:17334, Rhea:RHEA-COMP:17335, ChEBI:CHEBI:138284, CC ChEBI:CHEBI:173079, ChEBI:CHEBI:173080; CC Evidence={ECO:0000256|ARBA:ARBA00024600}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Endoplasmic reticulum-Golgi intermediate compartment CC {ECO:0000256|ARBA:ARBA00004399}. Host cytoplasm, host perinuclear CC region {ECO:0000256|ARBA:ARBA00004407}. Host endoplasmic reticulum- CC Golgi intermediate compartment {ECO:0000256|ARBA:ARBA00004452}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family. CC {ECO:0000256|ARBA:ARBA00008087, ECO:0000256|PROSITE-ProRule:PRU01294}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MZ081378; QWN56221.1; -; Genomic_RNA. DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell. DR GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW. DR GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule. DR GO; GO:0002151; F:G-quadruplex RNA binding; IEA:InterPro. DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW. DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW. DR GO; GO:0004483; F:mRNA (nucleoside-2'-O-)-methyltransferase activity; IEA:InterPro. DR GO; GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity; IEA:InterPro. DR GO; GO:0008242; F:omega peptidase activity; IEA:InterPro. DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-UniRule. DR GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW. DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-KW. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW. DR GO; GO:0039579; P:suppression by virus of host ISG15-protein conjugation; IEA:UniProtKB-KW. DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW. DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule. DR GO; GO:0019082; P:viral protein processing; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR CDD; cd21409; 1B_cv_Nsp13-like; 1. DR CDD; cd21901; alpha_betaCoV_Nsp10; 1. DR CDD; cd21560; betaCoV-Nsp6; 1. DR CDD; cd21722; betaCoV_Nsp13-helicase; 1. DR CDD; cd21659; betaCoV_Nsp14; 1. DR CDD; cd21516; betaCoV_Nsp2_SARS-like; 1. DR CDD; cd21666; betaCoV_Nsp5_Mpro; 1. DR CDD; cd21827; betaCoV_Nsp7; 1. DR CDD; cd21831; betaCoV_Nsp8; 1. DR CDD; cd21898; betaCoV_Nsp9; 1. DR CDD; cd21732; betaCoV_PLPro; 1. DR CDD; cd20762; capping_2-OMTase_Nidovirales; 1. DR CDD; cd21473; cv_Nsp4_TM; 1. DR CDD; cd21167; M_alpha_beta_cv_Nsp15-like; 1. DR CDD; cd21563; Macro_cv_SUD-M_Nsp3-like; 1. DR CDD; cd21557; Macro_X_Nsp3-like; 1. DR CDD; cd21161; NendoU_cv_Nsp15-like; 1. DR CDD; cd21171; NTD_alpha_betaCoV_Nsp15-like; 1. DR CDD; cd21796; SARS-CoV-like_Nsp1_N; 1. DR CDD; cd21822; SARS-CoV-like_Nsp3_NAB; 1. DR CDD; cd21591; SARS-CoV-like_RdRp; 1. DR CDD; cd21689; stalk_CoV_Nsp13-like; 1. DR CDD; cd21467; Ubl1_cv_Nsp3_N-like; 1. DR CDD; cd21401; ZBD_cv_Nsp13-like; 1. DR Gene3D; 1.10.8.1190; -; 1. DR Gene3D; 2.60.120.1680; -; 1. DR Gene3D; 3.10.20.350; -; 1. DR Gene3D; 3.10.20.540; -; 1. DR Gene3D; 3.40.50.11580; -; 1. DR Gene3D; 6.10.140.2090; -; 1. DR Gene3D; 1.10.150.420; Coronavirus nonstructural protein 4 C-terminus; 1. DR Gene3D; 3.40.30.150; Coronavirus polyprotein cleavage domain; 1. DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1. DR Gene3D; 1.10.1840.10; main proteinase (3clpro) structure, domain 3; 1. DR Gene3D; 3.30.160.820; Nsp15 N-terminal domain-like; 1. DR Gene3D; 3.40.220.20; Nsp3, SUD-M subdomain; 1. DR Gene3D; 3.40.220.30; Nsp3, SUD-N subdomain; 1. DR Gene3D; 1.10.8.370; nsp7 replicase; 1. DR Gene3D; 3.30.70.3540; Nsp8 replicase, head domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR Gene3D; 2.40.10.250; Replicase NSP9; 1. DR Gene3D; 3.40.50.11020; Replicase polyprotein, nucleic acid-binding domain; 1. DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2. DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1. DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom. DR InterPro; IPR046443; a/bCoV_NSP1_glob. DR InterPro; IPR046440; AV_NSP11N_COV_NSP15M. DR InterPro; IPR046442; bCoV_NSP1_C. DR InterPro; IPR043608; CoV_NSP15_M. DR InterPro; IPR043606; CoV_NSP15_N. DR InterPro; IPR043613; CoV_NSP2_C. DR InterPro; IPR047573; CoV_NSP2_M. DR InterPro; IPR043611; CoV_NSP3_C. DR InterPro; IPR047566; CoV_NSP3_Y3. DR InterPro; IPR032505; CoV_NSP4_C. DR InterPro; IPR043612; CoV_NSP4_N. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR041679; DNA2/NAM7-like_C. DR InterPro; IPR022733; DPUP_SUD_C_bCoV. DR InterPro; IPR037227; EndoU-like. DR InterPro; IPR002589; Macro_dom. DR InterPro; IPR043472; Macro_dom-like. DR InterPro; IPR044371; Macro_X_NSP3-like. DR InterPro; IPR046435; N7_MTase_CoV. DR InterPro; IPR043609; NendoU_nidovirus. DR InterPro; IPR044863; NIRAN. DR InterPro; IPR046438; NIV_2_O_MTASE. DR InterPro; IPR046436; NIV_EXON. DR InterPro; IPR036333; NSP10_sf_CoV. DR InterPro; IPR047570; NSP12_IF_CoV. DR InterPro; IPR044343; NSP13_1B_dom_CoV. DR InterPro; IPR048673; NSP13_stalk_CoV. DR InterPro; IPR048672; NSP13_ZBD_CoV. DR InterPro; IPR027352; NSP13_ZBD_CoV-like. DR InterPro; IPR044315; NSP14_betaCoV. DR InterPro; IPR009466; NSP14_CoV. DR InterPro; IPR044330; NSP15_alpha_betaCoV_N. DR InterPro; IPR044322; NSP15_M_alpha_beta_CoV. DR InterPro; IPR043174; NSP15_middle_sf. DR InterPro; IPR042515; NSP15_N_CoV. DR InterPro; IPR044401; NSP15_NendoU_CoV. DR InterPro; IPR009461; NSP16_CoV-like. DR InterPro; IPR021590; NSP1_glob_bCoV. DR InterPro; IPR038030; NSP1_glob_sf_bCoV. DR InterPro; IPR043615; NSP2_N_CoV. DR InterPro; IPR044389; NSP2_SARS-CoV-like. DR InterPro; IPR024375; NSP3_bCoV. DR InterPro; IPR047567; NSP3_G2M_bCoV. DR InterPro; IPR024358; NSP3_N_bCoV. DR InterPro; IPR032592; NSP3_NAB_bCoV. DR InterPro; IPR042570; NSP3_NAB_bCoV_sf. DR InterPro; IPR038166; NSP3_PL2pro_sf_bCoV. DR InterPro; IPR038400; NSP3_SUD-M_sf_bCoV. DR InterPro; IPR044864; NSP3_SUD-N_bCoV. DR InterPro; IPR043478; NSP3_SUD-N_sf_bCoV. DR InterPro; IPR044357; NSP3_Ubl1_dom_CoV. DR InterPro; IPR044353; Nsp3_Ubl2_dom_CoV. DR InterPro; IPR038083; NSP3A-like. DR InterPro; IPR038123; NSP4_C_sf_CoV. DR InterPro; IPR044367; NSP6_betaCoV. DR InterPro; IPR043610; NSP6_CoV. DR InterPro; IPR014828; NSP7_CoV. DR InterPro; IPR037204; NSP7_sf_CoV. DR InterPro; IPR014829; NSP8_CoV. DR InterPro; IPR037230; NSP8_sf_CoV. DR InterPro; IPR014822; NSP9_CoV. DR InterPro; IPR036499; NSP9_sf_CoV. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR013016; Peptidase_C16_CoV. DR InterPro; IPR008740; Peptidase_C30_CoV. DR InterPro; IPR043477; Peptidase_C30_dom3_CoV. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin. DR InterPro; IPR043177; PLpro_N_sf_CoV. DR InterPro; IPR043503; PLpro_palm_finger_dom_CoV. DR InterPro; IPR043178; PLpro_thumb_sf_CoV. DR InterPro; IPR046441; RdRp_CoV. DR InterPro; IPR009469; RdRp_N_CoV. DR InterPro; IPR044351; RdRp_SARS-CoV-like. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR018995; RNA_synth_NSP10_CoV. DR InterPro; IPR029063; SAM-dependent_MTases_sf. DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1. DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1. DR Pfam; PF13087; AAA_12; 1. DR Pfam; PF16251; bCoV_NAB; 1. DR Pfam; PF11501; bCoV_NSP1; 1. DR Pfam; PF12379; bCoV_NSP3_N; 1. DR Pfam; PF12124; bCoV_SUD_C; 1. DR Pfam; PF11633; bCoV_SUD_M; 1. DR Pfam; PF06471; CoV_ExoN; 1. DR Pfam; PF06460; CoV_Methyltr_2; 1. DR Pfam; PF09401; CoV_NSP10; 1. DR Pfam; PF20631; CoV_NSP13_1B; 1. DR Pfam; PF20633; CoV_NSP13_stalk; 1. DR Pfam; PF20632; CoV_NSP13_ZBD; 1. DR Pfam; PF19215; CoV_NSP15_C; 1. DR Pfam; PF19216; CoV_NSP15_M; 1. DR Pfam; PF19219; CoV_NSP15_N; 1. DR Pfam; PF19212; CoV_NSP2_C; 1. DR Pfam; PF19211; CoV_NSP2_N; 1. DR Pfam; PF19218; CoV_NSP3_C; 1. DR Pfam; PF16348; CoV_NSP4_C; 1. DR Pfam; PF19217; CoV_NSP4_N; 1. DR Pfam; PF19213; CoV_NSP6; 1. DR Pfam; PF08716; CoV_NSP7; 1. DR Pfam; PF08717; CoV_NSP8; 1. DR Pfam; PF08710; CoV_NSP9; 1. DR Pfam; PF08715; CoV_peptidase; 1. DR Pfam; PF06478; CoV_RPol_N; 1. DR Pfam; PF01661; Macro; 1. DR Pfam; PF05409; Peptidase_C30; 1. DR Pfam; PF00680; RdRP_1; 1. DR SMART; SM00506; A1pp; 1. DR SUPFAM; SSF144246; Coronavirus NSP10-like; 1. DR SUPFAM; SSF140367; Coronavirus NSP7-like; 1. DR SUPFAM; SSF143076; Coronavirus NSP8-like; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR SUPFAM; SSF142877; EndoU-like; 1. DR SUPFAM; SSF52949; Macro domain-like; 1. DR SUPFAM; SSF159936; NSP3A-like; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF101816; Replicase NSP9; 1. DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1. DR SUPFAM; SSF160099; SARS Nsp1-like; 1. DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1. DR PROSITE; PS51961; AV_NSP11N_COV_NSP15M; 1. DR PROSITE; PS51963; BCOV_NSP1_C; 1. DR PROSITE; PS51942; BCOV_NSP3C_C; 1. DR PROSITE; PS51941; BCOV_NSP3C_M; 1. DR PROSITE; PS51994; BCOV_NSP3E_G2M; 1. DR PROSITE; PS51945; BCOV_NSP3E_NAB; 1. DR PROSITE; PS51952; COV_EXON_MTASE_COACT; 1. DR PROSITE; PS51954; COV_N7_MTASE; 1. DR PROSITE; PS51962; COV_NSP1; 1. DR PROSITE; PS52000; COV_NSP12_IF; 1. DR PROSITE; PS51948; COV_NSP12_RDRP; 1. DR PROSITE; PS51960; COV_NSP15_NTD; 1. DR PROSITE; PS51991; COV_NSP2_C; 1. DR PROSITE; PS51990; COV_NSP2_M; 1. DR PROSITE; PS51989; COV_NSP2_N; 1. DR PROSITE; PS51992; COV_NSP3_Y3; 1. DR PROSITE; PS51943; COV_NSP3A_UBL; 1. DR PROSITE; PS51944; COV_NSP3D_UBL; 1. DR PROSITE; PS51946; COV_NSP4C; 1. DR PROSITE; PS51949; COV_NSP7; 1. DR PROSITE; PS51950; COV_NSP8; 1. DR PROSITE; PS51951; COV_NSP9_SSRNA_BD; 1. DR PROSITE; PS51653; CV_ZBD; 1. DR PROSITE; PS51442; M_PRO; 1. DR PROSITE; PS51154; MACRO; 1. DR PROSITE; PS51958; NENDOU; 1. DR PROSITE; PS51947; NIRAN; 1. DR PROSITE; PS51955; NIV_2_O_MTASE; 1. DR PROSITE; PS51953; NIV_EXON; 1. DR PROSITE; PS51124; PEPTIDASE_C16; 1. DR PROSITE; PS51657; PSRV_HELICASE; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. DR PROSITE; PS51940; SARS_NSP3C_N; 1. PE 3: Inferred from homology; KW Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|PROSITE- KW ProRule:PRU01303}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|ARBA:ARBA00023247}; KW Eukaryotic host translation shutoff by virus KW {ECO:0000256|ARBA:ARBA00022809, ECO:0000256|PROSITE-ProRule:PRU01308}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PROSITE- KW ProRule:PRU01298}; Helicase {ECO:0000256|ARBA:ARBA00022806}; KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200}; KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557, KW ECO:0000256|PROSITE-ProRule:PRU01308}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE- KW ProRule:PRU01303}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00022632, ECO:0000256|PROSITE-ProRule:PRU01308}; KW Inhibition of host interferon signaling pathway by virus KW {ECO:0000256|ARBA:ARBA00022830, ECO:0000256|PROSITE-ProRule:PRU01308}; KW Inhibition of host ISG15 by virus {ECO:0000256|ARBA:ARBA00023208}; KW Inhibition of host NF-kappa-B by virus {ECO:0000256|ARBA:ARBA00022863}; KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023208}; KW Lyase {ECO:0000256|ARBA:ARBA00023239}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE- KW ProRule:PRU01299}; KW Modulation of host ubiquitin pathway by viral deubiquitinase KW {ECO:0000256|ARBA:ARBA00022876}; KW Modulation of host ubiquitin pathway by virus KW {ECO:0000256|ARBA:ARBA00022662}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PROSITE- KW ProRule:PRU01298}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Protease {ECO:0000256|ARBA:ARBA00022670}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU01289}; KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484}; KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE- KW ProRule:PRU01299}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280, ECO:0000256|PROSITE- KW ProRule:PRU01308}; Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00444}. FT TRANSMEM 2211..2231 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2356..2379 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2754..2775 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3028..3050 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3062..3086 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3093..3115 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3121..3142 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3567..3590 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3596..3614 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3621..3642 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3668..3686 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3716..3740 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3752..3774 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 12..127 FT /note="CoV Nsp1 globular" FT /evidence="ECO:0000259|PROSITE:PS51962" FT DOMAIN 148..179 FT /note="BetaCoV Nsp1 C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51963" FT DOMAIN 183..456 FT /note="CoV Nsp2 N-terminal" FT /evidence="ECO:0000259|PROSITE:PS51989" FT DOMAIN 458..688 FT /note="CoV Nsp2 middle" FT /evidence="ECO:0000259|PROSITE:PS51990" FT DOMAIN 690..818 FT /note="CoV Nsp2 C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51991" FT DOMAIN 821..929 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS51943" FT DOMAIN 1012..1178 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51154" FT DOMAIN 1215..1343 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51940" FT DOMAIN 1351..1478 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51941" FT DOMAIN 1480..1552 FT /note="DPUP" FT /evidence="ECO:0000259|PROSITE:PS51942" FT DOMAIN 1550..1605 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS51944" FT DOMAIN 1619..1883 FT /note="Peptidase C16" FT /evidence="ECO:0000259|PROSITE:PS51124" FT DOMAIN 1896..2006 FT /note="Nucleic acid-binding" FT /evidence="ECO:0000259|PROSITE:PS51945" FT DOMAIN 2031..2140 FT /note="G2M" FT /evidence="ECO:0000259|PROSITE:PS51994" FT DOMAIN 2645..2748 FT /note="CoV Nsp3 Y" FT /evidence="ECO:0000259|PROSITE:PS51992" FT DOMAIN 3150..3248 FT /note="Nsp4C" FT /evidence="ECO:0000259|PROSITE:PS51946" FT DOMAIN 3249..3554 FT /note="Peptidase C30" FT /evidence="ECO:0000259|PROSITE:PS51442" FT DOMAIN 3845..3927 FT /note="RdRp Nsp7 cofactor" FT /evidence="ECO:0000259|PROSITE:PS51949" FT DOMAIN 3928..4125 FT /note="RdRp Nsp8 cofactor" FT /evidence="ECO:0000259|PROSITE:PS51950" FT DOMAIN 4126..4238 FT /note="Nsp9 ssRNA-binding" FT /evidence="ECO:0000259|PROSITE:PS51951" FT DOMAIN 4239..4377 FT /note="ExoN/MTase coactivator" FT /evidence="ECO:0000259|PROSITE:PS51952" FT DOMAIN 4384..4638 FT /note="NiRAN" FT /evidence="ECO:0000259|PROSITE:PS51947" FT DOMAIN 4643..4741 FT /note="Nsp12 Interface" FT /evidence="ECO:0000259|PROSITE:PS52000" FT DOMAIN 4742..5309 FT /note="Nsp12 RNA-dependent RNA polymerase" FT /evidence="ECO:0000259|PROSITE:PS51948" FT DOMAIN 4989..5151 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT DOMAIN 5310..5393 FT /note="CV ZBD" FT /evidence="ECO:0000259|PROSITE:PS51653" FT DOMAIN 5566..5917 FT /note="(+)RNA virus helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51657" FT DOMAIN 5982..6197 FT /note="ExoN" FT /evidence="ECO:0000259|PROSITE:PS51953" FT DOMAIN 6206..6437 FT /note="N7-MTase" FT /evidence="ECO:0000259|PROSITE:PS51954" FT DOMAIN 6438..6498 FT /note="Nsp15 N-terminal oligomerization" FT /evidence="ECO:0000259|PROSITE:PS51960" FT DOMAIN 6499..6624 FT /note="AV-Nsp11N/CoV-Nsp15M" FT /evidence="ECO:0000259|PROSITE:PS51961" FT DOMAIN 6641..6780 FT /note="NendoU" FT /evidence="ECO:0000259|PROSITE:PS51958" FT DOMAIN 6785..7079 FT /note="Nidovirus-type SAM-dependent 2'-O-MTase" FT /evidence="ECO:0000259|PROSITE:PS51955" FT REGION 6324..6338 FT /note="GpppA-binding" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01299" FT ACT_SITE 6000 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 6002 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 6101 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 6178 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 6183 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01298" FT ACT_SITE 6671 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303" FT ACT_SITE 6686 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303" FT ACT_SITE 6726 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01303" FT BINDING 6241..6247 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01299" SQ SEQUENCE 7081 AA; 791648 MW; CAC716B8946C4170 CRC64; MESLVPGFNE KTHVQLSLPV LQVRDVLVRG FGDSVEGALA EARQHLIDGT CGIIEVEKGV LPQLEQPFVF VKRSDARAAP HGHVVVELVA ELDGVQYGRS GETLGVLVPH VGEVPVAYRK ILLRKNGNKG AGGHSFGADL KSYDLGTDLV TDPFEDFEFN CNTKYSGGVT RNLMRELNGG SYTRYIDNNF CGPDGYPLEC VKDLLARAGK ASCTLAEQLD YLETKRGIYC CRDHDHEIAW FTERSDVSYA QQTPFEIKIA KKFDSFTGEC PKFVFPLNST VHVLQPRVDK KKMDGFMGRI RSVYPVSSPC ECNTMHLSIL MKCSHCDETS WQSGDFVNAT CEYCGTKNAV DDGPSTCGYL PQNPVVKISC PACHNPDMGP EHSVAEYHNE SGLKTILRKG GRTIQFGGCV FSYVGCYNKC AFWVPRASAN IGNRHTGIVG AETEALNDSL REVLHKDKIV INVVGDFKLT EEVAIILASF SASTSAFIDT IKGLDFKKFK QIVESCGNFK VARGEYKKGA WNIGESTSIL TPLHAFSTQA ASVVRSIFSR TMKTADCSVQ VLQSRAVDIL SSISEYSLRL IDAMSFTCEL ATDNLIVMAY VTGSLVQMTN QWFVNIFGMV HDQLKPVLNW LEDSLKSGVE FLKDGWEIFK VISQCACDIV SGQLVALTTE VKDCVKAFFA LVNKFLALCA DTIIIGGARL RALNLGETFI AHSKGLYKKC VRPKGDAGLL MPLKAPKEVV FLEGATLPTE VIAEEVVLKT GELQPLDEPA SADAKNPLVG TPVCINGLML LEIKDTTKYC ALSPNMLATN NLFTLKGGAP TKVTFGDDTV IEIQGYKTIK VTFELDERVD KALNEKCSDY TVELGTDVKE LACVVADNVV KTLTPLTDLL TPLGIDLDEW SVATFYLFDE AGDYKLASSM YCSFYPPSED YEDNASEFDQ QESTEYGTEA DYEGRTMEFE ATQQEFVEEE DWLADLEEST LETEVDPVSV AIDHEDPTVE SAAEEIQLQP TTNNANGYLK LTDNVFIKNV DIVEEALNMQ PQVIVNAANV YLKHGGGVAG ALNKATKGAM QLESDKYIAD RGPLQVGGSC VLSGHNLATN CLHVVGPNLT RGEDISLLAQ AYKNFNQFNC LLAPLLSAGI FGADPLVSLE ACIQNVNSTV FLVVFDKAMY DKLISDFLSK KSDAVQTKQS AIVQDTLQSE VSQLEVPQAE QTKQNVVPCV DEVTTTLEET KFLTKNLLVY IDINGKPYHD SLSLLGDMDL TFLTKDAPHI VGDIIISDFI TAVVIPTKKA GGTMSMLCKV LKNIPTNQYI TTYPGQGCAG YTIEEAKAAL KKAKSAFYIL PSNQPNKKEE ILGTVAWNLR EMLTHAEETR KLMPVCMDTR AIISTIQRRF KGIKVQEGVI DYGVRFYFYT SKTPIANVIA AINNLNETII TMPLGYVTHG LNLEEAARYM RSLKVPATVS VSSPEAVTAY NGYLTSSSKT AEEHFIETVS LAGSYKDWSY IGQSTTLGIA FLKRGDVVIY HTTNKPILFH KEGETIGLED LKKYLALREL RTIKVFTTVD NINLHTQIVD MSMTYGQQFG PIYLDGADVT KIKPHTNHDG KTFYVLPSDD VLRTEAFEHY HTTDESFLGR YMSALNLTKK WKYPQVGGLT SIKWADNNCY LATTLLTLQQ IEVKFNPPAL QDAYYRARAG DAANFCALIL AYSNKTVGEL GDVRETMAHL LRHVNLDTCK RVLNTVCKTC GQQQKTLHNL EAVMYMGTLS YDELKTGVKV PCVCGKDAIQ YLVQQESPFV MMSAPPATHE LEMGTFLCAS EYTGDYLCGH YKHITTKETI YSIDGALLTK MSEYKGFVTD VFYKESSYYT TISPVVYKLD GSIYTELNPN LDNYYKKDNA YFTEQPIDLI PNQPFPNASY DNFKFVCENS KFADDLNQIA GYSKPATREL QVTFYPDLTG DVVAIDYRHY TSAFKKGAKL VHKPILWHVN KTTNKATYKP NTWCIRCLWS TKPIDTANKF DVLQKEDAQG MDTLACAEVN DVTEEVVETP TVQKDIIECN VKQLETVGNV ILKPSQEGTK VTEELGHEDM MTAYIEKTSL TIKRPNELSE LLGLKTLLTH GVAAINSVPW NTIIMYAKPF LNTTASLTTD VLKRCVNRVC TDYMPYFVTL LLQLCTFTKH TNSKIRASLP TTIAKNTVKS VLRVCMEASI NYVKSINFSR ILTLVIWLLL IGVSLSSLVY LGSSLSLLMS VAGLPSYCNL YREGYLNSTN VTGTSYCSSY IPCMICLSDL DSLDLYPALA TIQVTISSFN WDFTLLCIVA EWFVAYILFT KAFYVLGLIA IMQLFLNLFS AHFVGNSWLM WFIINLVQMA PISAMVRMYI FFASFYYVWR CYVHVVDGCT SSTCMMCYKR NRATRVECTT IVNGVRRSFY VYANGGRGFC KLHNWNCVNC DTFCSGSTFI SDEVARDLSF QFKRTINPTD QSSYIVDNVV VKNGSLHLYF DKEGQKTYER HPLSHFVNLD NLRASNSKGS LPINVIVFDG KSKCEEAAAK VASVYYSQLM CQPILLLDQA LISDIGDSTE VAVKMFNAYV NTFAATFNAP IDKLKALITT AESELTKGVA LDNVLSTFIA AARQGFVDSD VDVKDIMECL KLSHQSDIEF TGDSCNNYML TYNKIDNMTP RDLGACIDCN ARQINAQVAK SHNISLIWNV RDFMSLSEQL RKQVRSAAKK NGLPFKLTCA TTRQVVNVVT TKISLKGGKL ITNWLKFMLK VTIGLTVLVT ILYCIMPVHI LSKHSDFSSE IIGYKAIEGG VTRDIVNTDN CFANKHVDFD SWFSQRGGSY KNDKSCPIVA AVITKDVGFV VPGLPGTILR TINGDFLHFL PRVFSAVGNI CYTPSKLIEY SDFSTAACVL AAECTIFKDA TGKPMPYCYD TNVLEGSIPY EDLRPDTRYV LMDGSIIQFP STYLEGSVRV VTTFDSEYCR HGTCERSEAG VCVSTSGRWV LNNDHYRSLP GVFCGVDAFN LLTNIFLPLV QPVGTMDISA SVIAGGFIAI VITCLAYYFM RFRRAFGEYS HVIASNALLF LMSFTVLCLT PSYAFVPSVY SLLYLYFTFY LANDVSFLAH VQWFVMFTPL VPFWITVLYG LCVFLKHFYW FFSNYLKRRI VFDGVSFSTF EEAALCTFLL NKEMYLKLRS DVLLPLTQYN RYLALYNKYK YFSGAMDTTS YREAACCHLA KALNDFSNSG SDVLYQPPQT SITSAVLQSG FRKMAFPSGK VEGCMVQVTC GTTTLNGLWL DDIVYCPRHV ICTAEDMLNP NYDDLLIRKS NHNFIVRAGN VQLRVIGHSM HNSVLRLKVD TANAKTPKYK FVRIQPGQTF SVLACYNGSP SGVYQCAMRP NYTIKGSFLN GSCGSVGFNI DYDCVSFCYM HHMELPTGVH AGTDLDGNFY GPFEDRQTAQ SAGTDTVITV NVLAWLYAAV INGDRWFLNH FTTTLNDFNL IAMKFNYEPL TQEQVDILGP LSAQTGIPVL SMCAALKEML QNGMNGRTIL GSAILEDEFT PFDVVRQCSG VTFQGAFKRT AKGTYHWLLL TALTSLLILV QTTQWSLFFF VYEHAFLPFV AGIVAMAAIS MMFVKHKHAF LCLFLLPSLA TIAYFNVVYM PASWLVRVMA WLEMIDTSLS GYKLKDCIMY VLASLLLILM TARTVYDDGA RRVWTLMNVF TLIYKVYYGN ALDQALAMWA LIISVTSNYS GVVTTIMFVA RGIVFMCVEY CPILFITGNT LQCIMLIYCV LGYFCTCYFG LFCLLNRYFR LTLGVYDYLV STQEFRYMNS QGLLPPKNSI DALKLNVKLL GIGGKPCIKV ATVQSKMSDV KCTSVVLLSV LQQLRIESSS KLWAQCVQLH NDILLAKDTT EAFEKMVSLL SVLLSMQGAV DINKLCEEML DNRATLQAIA SEFSSLPSYA AYATAQEAYE QAVANGDSDT VLKKLKKALN VAKSEFDRDA AMQRKLEKMA DQAMTQMYKQ ARSEDKRAKV TSAMQTMLFT MLRKLDNDAL NNIINNARDG CVPLNIIPLT TAAKLMVVVP DYNTYKNTCE GNTFTYASAL WEIQQIVDAD SKVVQLSEIT PDNSNIMAWP LIVTALRANS AVRLQNNELS PVALRQMSCA AGTTQNNCNE GSALAYYNTS KGGRFVLALL SDIQDLKWAR FPKSDGTGTI YTELEPPCRF VTDTPKGPKV KYLYFIKGLN NLNRGMVLGS LAATVRLQAG NATEVPANST VLSFCAFAVD AAKAYKDYLT SGGQPITNCV KMLCTHTGTG QAITVTPEAN MDQESFGGAS CCLYCRCHID HPNPKGYCEL KGKYVQIPTT CANDPVGFVL RNTVCAVCGM WKGYGCSCDQ LREPLLQSTD AQSFLNRVCG VSAARLTPCG TGTSTDVVYR AFDIYNDKIA GFAKFLKTNC CRFQEKDEDG NLIDSYFVVK RHTFSNYQHE ETIYNLLKDC PAVAKHDFFK FRIDGDMVPH ISRQRLTKYT MADLVYALRH FDEGNCDTLK EILVTYNCCD DEYFNKKDWY DFVENPDILR VYANLGERIR QALLKTVQFC DAMRDAGIVG VLTLDNQDLN GNWYDFGDFI QATPGSGVPV VDSYYSLLMP ILTLTRALTA ESHVDTDLTK PHIKWDLLKY DFTEERLKLF DRYFKYWDQT YHPNCVNCLD DRCILHCANF NVLFSTVFPP TSFGPLVRKI FVDGVPFVVS TGYHFRELGV VHNQDVNLHS SRLSFKELLV YAADPAMHAA SGNLLLDKRT TCFSVAALTN NVAFQTVKPG NFNKDFYDFA VSKGFFKEGS SIELKHFFFA QDGNAAISDY DYYRYNLPTM CDIRQLLFVV EVVDKYFDCY DGGCINANQV IVNNLDKSAG FPFNKWGKAR LYYDSMSYED QDALFAYTKR NVIPTITQMN LKYAISAKNR ARTVAGVSIC STMTNRQFHQ KLLKSIAATR GATVVIGTSK FYGGWHNMLK TVYSDVENPH LMGWDYPKCD RAMPNMLRIM ASLVLARKHT TCCSLSHRFY RLANECAQVL SEMVMCGGSL YVKPGGTSSG DATTAYANSV FNICQAITAN VNALLSTDGN KIADKYIRNL QHRLYECLYR NRDVDIDFVN EFYAYLRKHF SMMILSDDAV VCFNSTYASQ GLVASIKNFK SVLYYQNNVF MSEAKCWTET DLTKGPHEFC SQHTMLVKQG DDYVYLPYPD PSRILGAGCF VDDIVKTDGT LMIERFVSLA IDAYPLTKHP NQEYADVFHL YLQYIRKLHD ELTGHMLDMY SIMLTNDNTS RYWEPEFYEA MYTPHTVLQA VGACVLCNSQ TSLRCGACIR RPFLCCKCCY DHVISTSHKL VLSVNPYVCN APGCDVTDVT QLYLGGMSYY CKSHKPPISF PLCANGQVFG LYKNTCVGSD NVTDFNAIAT CDWTNAGDYI LANTCTERLK LFAAETLKAT EETFKLSYGI ATVREVLSDR ELHLSWEVGK PRPPLNRNYV FTGYRVTKNS KVQIGEYTFE KGDYGDAVVY RGTTTYKLNV GDYFVLTSHT VMPLSAPTLV PQEHYVRITG LYPTLNISDE FSSNVANYQK VGMQKYSTLQ GPPGTGKSHF AIGLALYYPS ARIVYTACSH AAVDALCEKA LKYLPIDKCS RIIPARARVE CFDKFKVNST LEQYVFCTVN ALPETTADIV VFDEISMATN YDLSVVNARL RAKHYVYIGD PAQLPAPRTL LTKGTLEPEY FNSVCRLMKT IGPDMFLGTC RRCPAEIVDT VSALVYENKL KAHKEKSAQC FKMFYKGVIT HDVSSAINRP QIGVVREFLT RNPAWRKAVF ISPYNSQNAV ASKILGLPTQ TVDSSQGSEY DYVIFAQTTE TAHSCNVNRF NVAITRAKVG ILCIMSDRDL YDSLQFTSLE VPRRNVANLQ AENVTGLFKD CSKIINGLHP TQAPTHLSVD TKFKTEGLCV DIPGIPKDMT YRRLISMMGF KMNYQVNGYP NMFITREEAI RHVRAWIGFD VEGCHATREA VGTNLPLQLG FSTGVNLVAV PTGYVDTPNN TDFSRVSAKP PPGDQFKHLI PLMYKGLPWN VVRIKIVQML SDTLRNLSDR VVFVLWAHGF ELTSMKYFVK IGPERTCCLC DRRATCFSTA SDTYACWHHS IGFDYVYNPF MIDVQQWGFT GNLQSNHDLY CQVHGNAHIA SCDAIMTRCL AVHECFVKRV DWTIEYPIIG DELKINAACR KVQHMVVKAA LLADKFSVLH DIGNPKAIKC VPQAEVEWKF YDAQPCGDKA YKIEELYYSY ATHSDKFTDG VCLFWNCNVD RYPANSIVCR FDTRVLSNLN LPGCDGGSLY VNKHAFHTPA FDKSAFVNLK QLPFFYYSDS PCESHGKQVV SDIDYVPLKS TTCITRCNLG GAVCKHHANE YRLYLDAYNM MISAGFSLWV YKQFDTYNLW NTFTKLQSLE NVAFNVVNKG HFDGQQGEVP VSIINNTVYT KVDGVDVELF ENKTTLPVNV AFELWAKRNI KPVPEVKILN NLGVDIAANT VIWDYKRDAP AYMSTIGVCT MTDIAKKPTE PTCASLTVLF DGRVEGQVDL FRNARNGVLY TEGSVKGLQS SVGPKHASLN GVTLVGEAVK TQFNYYKKVD GVIQQLPETY FTQSRTLQEF KPRSQMENDF LELAMDEFIH RYKLEGYAFE HIVYGDFSHS QLGGLHLLIG LTKRSMESPL VLEDFIPLDS TVKNYFITDA QTGSSKCVCS VIDLLLDDFV NIIKSQDLSV VSKVVKVTID YTEISFMLWC KDGHAETFYP KLQASQAWQP GVAMPNLYKM QRMLLDKCDI QNYGEAATLP KGIMMNVAKY TQLCQYLNTL TLAVPYNMRV IHFGAGSDKG VAPGTAVLRQ WLPTGTLLVD SDINDFVSDS DATLIGDCAT IHTANKWDLI ISDMYDPKTK NVTCENDSKE GFFTYICGFI QQRLALGGSV AIKITEHSWN ADLYRLMGHF AWWTAFVTNV NASSSEAFLI GCNYLGKQCE LIDGYVMHAN YVFWRNTNPI QLSSYSLFDM SKFPLKLKGT AVMSLKESQI NDMILSLLSK GRLIIRENNK VVFSNDVLVN V //