ID A0A8E8PBQ3_9NEOB Unreviewed; 183 AA. AC A0A8E8PBQ3; DT 19-JAN-2022, integrated into UniProtKB/TrEMBL. DT 19-JAN-2022, sequence version 1. DT 29-MAY-2024, entry version 7. DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037}; DE Short=NT-3 {ECO:0000256|RuleBase:RU365037}; DE Flags: Fragment; GN Name=NTF3 {ECO:0000313|EMBL:QWE48611.1}; OS Occidozyga laevis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Neobatrachia; Ranoidea; Dicroglossidae; Occidozyginae; OC Occidozyga. OX NCBI_TaxID=50909 {ECO:0000313|EMBL:QWE48611.1}; RN [1] {ECO:0000313|EMBL:QWE48611.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SH0196 {ECO:0000313|EMBL:QWE48611.1}, and SH0278 RC {ECO:0000313|EMBL:QWE48667.1}; RX PubMed=34029720; RA Flury J.M., Haas A., Brown R.M., Das I., Pui Y.M., Boon-Hee K., Scheidt U., RA Iskandar D.T., Jankowski A., Hertwig S.T.; RT "Unexpectedly high levels of lineage diversity in Sundaland puddle frogs RT (Dicroglossidae: Occidozyga Kuhl and van Hasselt, 1822)."; RL Mol. Phylogenet. Evol. 163:0-107210(2021). CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312, CC ECO:0000256|RuleBase:RU365037}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU365037}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MT572733; QWE48611.1; -; Genomic_DNA. DR EMBL; MT572789; QWE48667.1; -; Genomic_DNA. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0008021; C:synaptic vesicle; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005163; F:nerve growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0007613; P:memory; IEA:TreeGrafter. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:0021675; P:nerve development; IEA:TreeGrafter. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IEA:TreeGrafter. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter. DR GO; GO:0007422; P:peripheral nervous system development; IEA:TreeGrafter. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:TreeGrafter. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:TreeGrafter. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR045815; NTF3_N. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1. DR Pfam; PF00243; NGF; 1. DR Pfam; PF19338; NTF3_N; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS50270; NGF_2; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037}; KW Growth factor {ECO:0000256|RuleBase:RU365037}; KW Secreted {ECO:0000256|RuleBase:RU365037}; KW Signal {ECO:0000256|ARBA:ARBA00022729}. FT DOMAIN 120..183 FT /note="Nerve growth factor-related" FT /evidence="ECO:0000259|SMART:SM00140" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QWE48611.1" FT NON_TER 183 FT /evidence="ECO:0000313|EMBL:QWE48611.1" SQ SEQUENCE 183 AA; 20863 MW; 70D15137F9498F00 CRC64; NSFFIKLMQA DLVKNKVSKQ VANAKANHQQ NTIPKTEILV DLDMVDDSLE SGKSDFQPVT SLEAELFKQQ RQRRYNSPRV LLSGNLPLEP PPLYLMDDFV GHSHSTNRTS RRKRYAEHRS HRGEFSVCDS ESLWVTDKSN AIDIRGHQVT VLGEIKSGNS PVKQYFYETR CKDARPVKNG CRG //