ID   A0A8D0X2F5_PIG          Unreviewed;       602 AA.
AC   A0A8D0X2F5;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   24-JAN-2024, entry version 10.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00030028889.1, ECO:0000313|Proteomes:UP000694570};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00030028889.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSSSCT00030063147.1; ENSSSCP00030028889.1; ENSSSCG00030044945.1.
DR   Proteomes; UP000694570; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR44329:SF253; -; 1.
DR   PANTHER; PTHR44329; SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   SMART; SM00109; C1; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          100..144
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          338..584
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          184..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..235
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  68125 MW;  25880FA7233F6570 CRC64;
     MCVGLHFPLL FLCLPFRAKK KSKPLNLKIH SSVGSCENIP SQQRSPLLSE RSLRSFFVGH
     APFLPSTPPV HTEVNFSANT LSVPRWSPQI PRRDLGNSIK HRFSTKYWMS QTCTVCGKGM
     LFGLKCKNCK LKCHNKCTKE APPCHLLIIH RGARLVRTES VPCDINNPLR KPPRYSDLHI
     SQTLPKTNKI NKDHIPVPYQ PDSSSNPSST TSSTPSSPAP PLPPSATPPS PLHPSPQCTR
     QQKNFNLPDV VPVPETPTRA PQVILHPVTS NPILEGNPLL QIEVEPTSEN EEGHDEAEES
     EDDFEEMNLS LLSARSFPRK ASQTSIFLQE WDIPFEQLEI GELIGKGRFG QVYHGRWHGE
     VAIRLIDIER DNEEQLKAFK REVMAYRQTR HENVVLFMGA CMSPPHLAII TSLCKGRTLY
     SVVRDAKIVL DVNKTRQIAQ EIVKGLGVSA RGLVLLGLSN RAHSVLCFSR RDDKLRIQNG
     WLCHLAPEII RQLSPDTEED KLPFSKHSDV FALGTIWYEL HAREWPFKTQ PAEAIIWQMG
     TGMKPNLSQI GMGKEISDIL LFCWAFEQEE RPTFTKLMDM LEKLPKRNRR LSHPGHFWKS
     AE
//