ID A0A8D0KES4_PIG Unreviewed; 184 AA. AC A0A8D0KES4; DT 19-JAN-2022, integrated into UniProtKB/TrEMBL. DT 19-JAN-2022, sequence version 1. DT 24-JUL-2024, entry version 12. DE RecName: Full=RNA polymerase Rpb4/RPC9 core domain-containing protein {ECO:0000259|SMART:SM00657}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00005037495.1}; RN [1] {ECO:0000313|Ensembl:ENSSSCP00005037495.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. RN [2] {ECO:0007829|PDB:8UHA, ECO:0007829|PDB:8UHD} RP STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 43-184. RX PubMed=38401543; DOI=10.1016/j.molcel.2024.01.023; RA Su B.G., Vos S.M.; RT "Distinct negative elongation factor conformations regulate RNA polymerase RT II promoter-proximal pausing."; RL Mol. Cell 84:1243-1256.e5(2024). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the eukaryotic RPB4 RNA polymerase subunit CC family. {ECO:0000256|ARBA:ARBA00025724}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PDB; 8UHA; EM; 3.50 A; D=43-184. DR PDB; 8UHD; EM; 2.80 A; D=43-184. DR PDB; 8UHG; EM; 2.70 A; D=43-184. DR PDB; 8UI0; EM; 2.70 A; D=43-184. DR PDB; 8UIS; EM; 3.23 A; D=43-184. DR EMDB; EMD-42267; -. DR EMDB; EMD-42270; -. DR EMDB; EMD-42280; -. DR EMDB; EMD-42285; -. DR EMDB; EMD-42303; -. DR SMR; A0A8D0KES4; -. DR Ensembl; ENSSSCT00005060711.1; ENSSSCP00005037495.1; ENSSSCG00005037960.1. DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:TreeGrafter. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0031369; F:translation initiation factor binding; IEA:TreeGrafter. DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:TreeGrafter. DR Gene3D; 1.20.1250.40; -; 1. DR InterPro; IPR010997; HRDC-like_sf. DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core. DR InterPro; IPR045222; Rpb4-like. DR InterPro; IPR005574; Rpb4/RPC9. DR InterPro; IPR038324; Rpb4/RPC9_sf. DR PANTHER; PTHR21297; DNA-DIRECTED RNA POLYMERASE II; 1. DR PANTHER; PTHR21297:SF0; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4; 1. DR Pfam; PF03874; RNA_pol_Rpb4; 1. DR SMART; SM00657; RPOL4c; 1. DR SUPFAM; SSF47819; HRDC-like; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:8UHA, ECO:0007829|PDB:8UHD}; KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}. FT DOMAIN 66..183 FT /note="RNA polymerase Rpb4/RPC9 core" FT /evidence="ECO:0000259|SMART:SM00657" SQ SEQUENCE 184 AA; 20952 MW; 99B30E47A8755F94 CRC64; MWGPAQPYSD SALSPKPRPF RAVFRGSALL FPAVRVEVRG RSMAAGGSDP RAGDVEEDAS QLIFPKEFET AETLLNSEVH MLLEHRKQQN ESAEDEQELS EVFMKTLNYT ARFSRFKNRE TIASVRSLLL QKKLHKFELA CLANLCPETA EESKALIPSL EGRFEDEELQ QILDDIQTKR SFQY //