ID   A0A8C9WZ66_SANLU        Unreviewed;       530 AA.
AC   A0A8C9WZ66;
DT   19-JAN-2022, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2022, sequence version 1.
DT   14-DEC-2022, entry version 5.
DE   RecName: Full=O-acyltransferase {ECO:0000256|PIRNR:PIRNR000439};
GN   Name=dgat1 {ECO:0000313|Ensembl:ENSSLUP00000001486.1};
OS   Sander lucioperca (Pike-perch) (Perca lucioperca).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Percoidei; Percidae; Luciopercinae; Sander.
OX   NCBI_TaxID=283035 {ECO:0000313|Ensembl:ENSSLUP00000001486.1, ECO:0000313|Proteomes:UP000694568};
RN   [1] {ECO:0000313|Ensembl:ENSSLUP00000001486.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)
CC         = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823,
CC         ChEBI:CHEBI:52323, ChEBI:CHEBI:53753;
CC         Evidence={ECO:0000256|ARBA:ARBA00000645};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38380;
CC         Evidence={ECO:0000256|ARBA:ARBA00000645};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387; Evidence={ECO:0000256|ARBA:ARBA00000389};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220;
CC         Evidence={ECO:0000256|ARBA:ARBA00000389};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38435,
CC         ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75735; Evidence={ECO:0000256|ARBA:ARBA00000883};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38436;
CC         Evidence={ECO:0000256|ARBA:ARBA00000883};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-
CC         (9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915,
CC         ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75342; Evidence={ECO:0000256|ARBA:ARBA00001009};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916;
CC         Evidence={ECO:0000256|ARBA:ARBA00001009};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-
CC         (9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA;
CC         Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387, ChEBI:CHEBI:138734;
CC         Evidence={ECO:0000256|ARBA:ARBA00000304};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341;
CC         Evidence={ECO:0000256|ARBA:ARBA00000304};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-
CC         octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-
CC         octadecenoyl)glycerol + CoA; Xref=Rhea:RHEA:55344, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57387, ChEBI:CHEBI:138734, ChEBI:CHEBI:138735;
CC         Evidence={ECO:0000256|ARBA:ARBA00000605};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55345;
CC         Evidence={ECO:0000256|ARBA:ARBA00000605};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-
CC         eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-
CC         eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA;
CC         Xref=Rhea:RHEA:38307, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75728, ChEBI:CHEBI:75729;
CC         Evidence={ECO:0000256|ARBA:ARBA00001100};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38308;
CC         Evidence={ECO:0000256|ARBA:ARBA00001100};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol =
CC         1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38439,
CC         ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:75824; Evidence={ECO:0000256|ARBA:ARBA00001338};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38440;
CC         Evidence={ECO:0000256|ARBA:ARBA00001338};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-
CC         (9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:37911,
CC         ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387,
CC         ChEBI:CHEBI:73990; Evidence={ECO:0000256|ARBA:ARBA00001793};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37912;
CC         Evidence={ECO:0000256|ARBA:ARBA00001793};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-
CC         di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA;
CC         Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57379, ChEBI:CHEBI:75583;
CC         Evidence={ECO:0000256|ARBA:ARBA00001349};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164;
CC         Evidence={ECO:0000256|ARBA:ARBA00001349};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl
CC         hexadecanoate + CoA; Xref=Rhea:RHEA:55296, ChEBI:CHEBI:45479,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:138722;
CC         Evidence={ECO:0000256|ARBA:ARBA00000895};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55297;
CC         Evidence={ECO:0000256|ARBA:ARBA00000895};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-
CC         hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA;
CC         Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC         ChEBI:CHEBI:73990, ChEBI:CHEBI:75466;
CC         Evidence={ECO:0000256|ARBA:ARBA00001313};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072;
CC         Evidence={ECO:0000256|ARBA:ARBA00001313};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol
CC         + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001150};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869;
CC         Evidence={ECO:0000256|ARBA:ARBA00001150};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester +
CC         CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00000633};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489;
CC         Evidence={ECO:0000256|ARBA:ARBA00000633};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl
CC         hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336,
CC         ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379;
CC         Evidence={ECO:0000256|ARBA:ARBA00001764};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176;
CC         Evidence={ECO:0000256|ARBA:ARBA00001764};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl
CC         hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584;
CC         Evidence={ECO:0000256|ARBA:ARBA00001796};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168;
CC         Evidence={ECO:0000256|ARBA:ARBA00001796};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-
CC         dihexadecanoyl-1,2-hexadecanediol + 2 CoA; Xref=Rhea:RHEA:38211,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586,
CC         ChEBI:CHEBI:75608; Evidence={ECO:0000256|ARBA:ARBA00001118};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38212;
CC         Evidence={ECO:0000256|ARBA:ARBA00001118};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl
CC         hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587;
CC         Evidence={ECO:0000256|ARBA:ARBA00000174};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38172;
CC         Evidence={ECO:0000256|ARBA:ARBA00000174};
CC   -!- PATHWAY: Lipid metabolism; glycerolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00005175}.
CC   -!- SUBUNIT: Homodimer or homotetramer; both forms have similar enzymatic
CC       activities. {ECO:0000256|ARBA:ARBA00023610}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|PIRNR:PIRNR000439}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC       Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010,
CC       ECO:0000256|PIRNR:PIRNR000439}.
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DR   Ensembl; ENSSLUT00000001564.1; ENSSLUP00000001486.1; ENSSLUG00000000703.1.
DR   GeneTree; ENSGT00950000183081; -.
DR   UniPathway; UPA00230; -.
DR   Proteomes; UP000694568; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IEA:InterPro.
DR   GO; GO:0019432; P:triglyceride biosynthetic process; IEA:InterPro.
DR   InterPro; IPR027251; Diacylglycerol_acylTrfase1.
DR   InterPro; IPR004299; MBOAT_fam.
DR   InterPro; IPR014371; Oat_ACAT_DAG_ARE.
DR   PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1.
DR   Pfam; PF03062; MBOAT; 1.
DR   PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
DR   PIRSF; PIRSF500231; Oat_dag; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|PIRNR:PIRNR000439};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|PIRNR:PIRNR000439};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000439};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694568};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000439};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        124..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        198..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        471..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        501..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        460
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000439-1"
SQ   SEQUENCE   530 AA;  61152 MW;  452BB8F4E282B9AF CRC64;
     MTEAAEMSDR AEMRGPVSRR RRTTISGGGG SGAVKQANGS KWHDAGEKLP LYPAKAKTDE
     VPRQASNNGK VDREMGMSGQ QQQLAKRTRK QRSLVEDINE KLSCHVLQES LLSSASGYSN
     YRGILNWCVV MLVLSNARLF LENIIKYGIL VDPIQVVSLF LKDPYSWPAA CLIIVSNVFI
     LAALYTERRL AVGTITQMTG LIFHIFNLTS MLIFPSATVL IVTSMTPVGG VLSLGIYTVL
     FLKLYSYQDT NRWCREIRQA KAKRLTRSYS CPSVAQSNGS AGHTHVSYPG NLTHRDMYYF
     VFAPTLCYQL NFPRSPRIRI RFLMRRLFEM LFFMQLLVGL IQQWMVPTIQ NSMKPFQEMD
     FSRMVERLLK LAVPNHLIWL IFFYWFFHSS MNFVAELLQF GDREFYKDWW NSETVTYFWA
     NWNIPVHKWC LRHFYKPMLR KGVNKFLAQT AVFLMSAFFH EYLVSVPLKM FRLWAFMGMM
     AQVPLAWFVG RFLNGNYGNA AVWMSLIIGQ PVAVLMYVHD YYVIHYGSTT
//