ID A0A8C0Q3R4_CANLF Unreviewed; 317 AA. AC A0A8C0Q3R4; DT 19-JAN-2022, integrated into UniProtKB/TrEMBL. DT 19-JAN-2022, sequence version 1. DT 03-MAY-2023, entry version 7. DE RecName: Full=E3 ubiquitin-protein ligase NRDP1 {ECO:0000256|ARBA:ARBA00015711}; DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483}; DE AltName: Full=RING finger protein 41 {ECO:0000256|ARBA:ARBA00030556}; DE AltName: Full=RING-type E3 ubiquitin transferase NRDP1 {ECO:0000256|ARBA:ARBA00031762}; GN Name=RNF41 {ECO:0000313|Ensembl:ENSCAFP00040008103.1}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00040008103.1, ECO:0000313|Proteomes:UP000694542}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00040008103.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900}; CC -!- PATHWAY: Protein modification; protein ubiquitination. CC {ECO:0000256|ARBA:ARBA00004906}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_005625547.1; XM_005625490.2. DR RefSeq; XP_005625548.1; XM_005625491.2. DR RefSeq; XP_848722.1; XM_843629.4. DR RefSeq; XP_856953.1; XM_851860.4. DR Ensembl; ENSCAFT00030026915.1; ENSCAFP00030023488.1; ENSCAFG00030014581.1. DR Ensembl; ENSCAFT00040009357.1; ENSCAFP00040008103.1; ENSCAFG00040004969.1. DR OMA; ENYVCKR; -. DR UniPathway; UPA00143; -. DR Proteomes; UP000694429; Chromosome 10. DR Proteomes; UP000694542; Chromosome 10. DR GO; GO:0071782; C:endoplasmic reticulum tubular network; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0005128; F:erythropoietin receptor binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0005135; F:interleukin-3 receptor binding; IEA:Ensembl. DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl. DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl. DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl. DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:1901525; P:negative regulation of mitophagy; IEA:Ensembl. DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl. DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl. DR GO; GO:0010498; P:proteasomal protein catabolic process; IEA:Ensembl. DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl. DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl. DR GO; GO:0045619; P:regulation of lymphocyte differentiation; IEA:Ensembl. DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl. DR GO; GO:0045637; P:regulation of myeloid cell differentiation; IEA:Ensembl. DR GO; GO:0051896; P:regulation of protein kinase B signaling; IEA:Ensembl. DR CDD; cd16634; mRING-HC-C3HC3D_Nrdp1; 1. DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2. DR InterPro; IPR015036; NRDP1. DR InterPro; IPR037255; NRDP1_C. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR InterPro; IPR013010; Znf_SIAH. DR PANTHER; PTHR10131:SF94; MATH DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1. DR Pfam; PF08941; USP8_interact; 1. DR Pfam; PF13923; zf-C3HC4_2; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF160088; NRDP1 C-terminal domain-like; 1. DR SUPFAM; SSF57850; RING/U-box; 1. DR SUPFAM; SSF49599; TRAF domain-like; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. DR PROSITE; PS51081; ZF_SIAH; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00455}. FT DOMAIN 18..57 FT /note="RING-type" FT /evidence="ECO:0000259|PROSITE:PS50089" FT DOMAIN 78..138 FT /note="SIAH-type" FT /evidence="ECO:0000259|PROSITE:PS51081" FT COILED 135..169 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 317 AA; 35905 MW; 46AE87AF8BE1A369 CRC64; MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC GLEMPKDELP NHNCIKHLRS VVQQQQTRIA ELEKTSAEHK HQLAEQKRDI QLLKAYMRAI RSVNPNLQNL EETIEYNEIL EWVNSLQPAR VTRWGGMIST PDAVLQAVIK RSLVESGCPA SIVNELIENA HERSWPQGLA TLETRQMNRR YYENYVAKRI PGKQAVVVMA CENQHMGDDM VQEPGLVMIF AHGVEEI //