ID A0A8B9YFX3_BOSMU Unreviewed; 406 AA. AC A0A8B9YFX3; DT 19-JAN-2022, integrated into UniProtKB/TrEMBL. DT 19-JAN-2022, sequence version 1. DT 27-NOV-2024, entry version 14. DE RecName: Full=Vasopressin V2 receptor {ECO:0000256|ARBA:ARBA00014011, ECO:0000256|RuleBase:RU046427}; GN Name=AVPR2 {ECO:0000313|Ensembl:ENSBGRP00000034416.1}; OS Bos mutus grunniens (Wild yak) (Bos grunniens). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=30521 {ECO:0000313|Ensembl:ENSBGRP00000034416.1, ECO:0000313|Proteomes:UP000694520}; RN [1] {ECO:0000313|Ensembl:ENSBGRP00000034416.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- FUNCTION: Involved in renal water reabsorption. Receptor for arginine CC vasopressin. The activity of this receptor is mediated by G proteins CC which activate adenylate cyclase. {ECO:0000256|RuleBase:RU046427}. CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this CC receptor is mediated by G proteins which activate adenylate cyclase. CC Involved in renal water reabsorption. {ECO:0000256|ARBA:ARBA00045632}. CC -!- SUBUNIT: Interacts with ARRDC4. Identified in a complex containing at CC least ARRDC4, V2R and HGS. Interacts with TMEM147. CC {ECO:0000256|ARBA:ARBA00046856}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Vasopressin/oxytocin receptor subfamily. CC {ECO:0000256|RuleBase:RU046427}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSBGRT00000039795.1; ENSBGRP00000034416.1; ENSBGRG00000021537.1. DR GeneTree; ENSGT01050000244882; -. DR Proteomes; UP000694520; Chromosome X. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042277; F:peptide binding; IEA:TreeGrafter. DR GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule. DR GO; GO:0032870; P:cellular response to hormone stimulus; IEA:TreeGrafter. DR GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:TreeGrafter. DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IEA:TreeGrafter. DR CDD; cd15388; 7tmA_V2R; 1. DR FunFam; 1.20.1070.10:FF:000190; Vasopressin V2 receptor; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR000161; Vprsn_rcpt_V2. DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24241:SF20; VASOPRESSIN V2 RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00898; VASOPRSNV2R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU046427}; KW Glycoprotein {ECO:0000256|RuleBase:RU046427}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU046427}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU046427}; KW Reference proteome {ECO:0000313|Proteomes:UP000694520}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU046427}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU046427}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU046427}. FT TRANSMEM 77..99 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 111..130 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 150..171 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 192..215 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 240..264 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 309..331 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 343..363 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT DOMAIN 90..360 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 383..406 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 390..406 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 406 AA; 43909 MW; 9400523863B14E63 CRC64; MCCAGRPGAG REEAGGKQRA QVDSGLVPGQ NRLTDLALCP HLCPAVPWHL SQPTPAGNGS EGELLTARDP LLAQAELALL STVFVAVALS NGLVLGALVR RGRRGRWAPM HVFIGHLCLA DLAVALFQLL PQLAWDATDR FRGPDALCRA VKYLQMVGMY ASSYMILAMT LDRHRAICRP MLAHRHGGGT HWNRPVLLAW AFSLLFSLPQ LFIFAQRDVD GSGVLDCWAR FAEPWGLRAY VTWIALMVFV APALGIAACQ VLIFREIHAS LGPGPVPRAG GPRRGCRPGS PAEGARVSAA VAKTVKMTLV IVIVYVLCWA PFFLVQLWAA WDPEAPREGP PFVLLMLLAS LNSCTNPWIY ASFSSSISSE LRSLLCCTWR RAPPSPGPQE ESCATASSFL AKDTPS //