ID A0A8B6RWD7_SARS2 Unreviewed; 192 AA. AC A0A8B6RWD7; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 25-MAY-2022, entry version 3. DE SubName: Full=ORF3a protein {ECO:0000313|EMBL:QTZ54255.1}; DE Flags: Fragment; GN Name=ORF3a {ECO:0000313|EMBL:QTZ54255.1}; OS Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Sarbecovirus. OX NCBI_TaxID=2697049 {ECO:0000313|EMBL:QTZ54255.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:QTZ54255.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SARS-CoV-2/human/USA/CA-IGI-3096/2021 RC {ECO:0000313|EMBL:QTZ54255.1}; RX PubMed=33758899; RA Deng X., Garcia-Knight M.A., Khalid M.M., Servellita V., Wang C., RA Morris M.K., Sotomayor-Gonzalez A., Glasner D.R., Reyes K.R., Gliwa A.S., RA Reddy N.P., Sanchez San Martin C., Federman S., Cheng J., Balcerek J., RA Taylor J., Streithorst J.A., Miller S., Kumar G.R., Sreekumar B., RA Chen P.Y., Schulze-Gahmen U., Taha T.Y., Hayashi J., Simoneau C.R., RA McMahon S., Lidsky P.V., Xiao Y., Hemarajata P., Green N.M., Espinosa A., RA Kath C., Haw M., Bell J., Hacker J.K., Hanson C., Wadford D.A., Anaya C., RA Ferguson D., Lareau L.F., Frankino P.A., Shivram H., Wyman S.K., Ott M., RA Andino R., Chiu C.Y.; RT "Transmission, infectivity, and antibody neutralization of an emerging RT SARS-CoV-2 variant in California carrying a L452R spike protein mutation."; RL medRxiv 0:0-0(2021). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm CC {ECO:0000256|ARBA:ARBA00004496}. Host cell membrane CC {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004598}. Host cytoplasm CC {ECO:0000256|ARBA:ARBA00004192}. Virion CC {ECO:0000256|ARBA:ARBA00004328}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MW974459; QTZ54255.1; -; Genomic_RNA. DR GO; GO:0005216; F:ion channel activity; IEA:InterPro. DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro. DR InterPro; IPR024407; Protein_3a_bCoV. DR Pfam; PF11289; bCoV_viroporin; 1. PE 4: Predicted; KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511}; KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200}; KW Host membrane {ECO:0000256|ARBA:ARBA00022511}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Virion {ECO:0000256|ARBA:ARBA00022844}. FT TRANSMEM 35..56 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 77..101 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 107..129 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT NON_TER 192 FT /evidence="ECO:0000313|EMBL:QTZ54255.1" SQ SEQUENCE 192 AA; 21791 MW; 3A057C9DAF6A51D2 CRC64; MDLFMRIFTI GTVTLKQGEI KDATPSDFVR ATATIPIQAS LPFGWLIVGV ALLAVFHSAS KIITLKKRWQ LALSKGVHFV CNLLLLFVTV YSHLLLVAAG LEAPFLYLYA LVYFLQSINF VRIIMRLWLC WKCRSKNPLL YDANYFLCWH TNCYDYCIPY NSVTSSIVIT SVDGTTSPIS EHDYQIGGYT EK //