ID A0A8A6MUM8_POVBK Unreviewed; 695 AA. AC A0A8A6MUM8; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 25-MAY-2022, entry version 3. DE RecName: Full=Large T antigen {ECO:0000256|ARBA:ARBA00018805}; OS BK polyomavirus (BKPyV) (Human polyomavirus 1). OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; OC Sepolyvirales; Polyomaviridae; Betapolyomavirus. OX NCBI_TaxID=1891762 {ECO:0000313|EMBL:QTJ14971.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:QTJ14971.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=UBK065 {ECO:0000313|EMBL:QTJ14971.1}; RA Addetia A., Phung Q., Greninger A.; RT "Defective polyomavirus genomes in clinical urine samples."; RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MW587965; QTJ14971.1; -; Genomic_DNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:InterPro. DR CDD; cd06257; DnaJ; 1. DR Gene3D; 1.10.10.510; -; 1. DR Gene3D; 1.10.287.110; -; 1. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR001623; DnaJ_domain. DR InterPro; IPR014015; Helicase_SF3_DNA-vir. DR InterPro; IPR036869; J_dom_sf. DR InterPro; IPR016392; Lg_T_Ag_polyomavir. DR InterPro; IPR010932; Lg_T_Ag_Polyomavir_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR003133; T_Ag_DNA-bd. DR InterPro; IPR017910; Znf_lg_T-Ag_D1-typ. DR InterPro; IPR037102; Znf_lg_T-Ag_D1_dom_sf. DR Pfam; PF06431; Polyoma_lg_T_C; 1. DR Pfam; PF02217; T_Ag_DNA_bind; 1. DR PIRSF; PIRSF003368; Large_T_antigen_polyomaV; 2. DR SMART; SM00271; DnaJ; 1. DR SUPFAM; SSF46565; SSF46565; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS50076; DNAJ_2; 1. DR PROSITE; PS51206; SF3_HELICASE_1; 1. DR PROSITE; PS51287; T_AG_OBD; 1. DR PROSITE; PS51341; ZF_LTAG_D1; 1. PE 4: Predicted; KW Acetylation {ECO:0000256|ARBA:ARBA00022990}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00620}; KW Early protein {ECO:0000256|ARBA:ARBA00022518}; KW G1/S host cell cycle checkpoint dysregulation by virus KW {ECO:0000256|ARBA:ARBA00023309}; KW Host nucleus {ECO:0000256|ARBA:ARBA00022562}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00022632}; KW Inhibition of host interferon signaling pathway by virus KW {ECO:0000256|ARBA:ARBA00022830}; KW Inhibition of host JAK1 by virus {ECO:0000256|ARBA:ARBA00023318}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Modulation of host cell cycle by virus {ECO:0000256|ARBA:ARBA00022504}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00671}. FT DOMAIN 12..75 FT /note="J" FT /evidence="ECO:0000259|PROSITE:PS50076" FT DOMAIN 141..256 FT /note="T-ag OBD" FT /evidence="ECO:0000259|PROSITE:PS51287" FT DOMAIN 267..359 FT /note="T-ag D1-type" FT /evidence="ECO:0000259|PROSITE:PS51341" FT DOMAIN 402..562 FT /note="SF3 helicase" FT /evidence="ECO:0000259|PROSITE:PS51206" FT DNA_BIND 141..256 FT /note="T-ag OBD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00620" FT REGION 117..138 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 634..679 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 643..668 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 695 AA; 80504 MW; 4684AE4947F981CC CRC64; MDKVLNREES MELMDLLGLE RAAWGNLPLM RKAYLRKCKE FHPDKGGDED KMKRMNTLYK KMEQDVKVAH QPDFGTWSSS EVPTYGTEEW ESWWSSFNEK WDEDLFCHED MFASDEEATA DSQHSTPPKK KRKVEDPKDF PSDLHQFLSQ AVFSNRTLAC FAVYTTKEKA QILYKKLMEK YSVTFISRHM CAGHNIIFFL TPHRHRVSAI NNFCQKLCTF SFLICKGVNK EYLLYSALTR DPYHTIEESI QGGLKEHDFN PEEPEETKQV SWKLITEYAV ETKCEDVFLL LGMYLEDRYN VEECKKCQKK DQPYHFKYHE KHFANATIFA ESKNQKSICQ QAVDTVLAKK RVDSLHMTRE EMLTERFNHI LDKMDLIFGA HGNAVLEQYM AGVAWLHCLL PKMDSVIFDF LHCIVFNVPK RRYWLFKGPI DSGKTTLAAG LLDLCGGKAL NVNLPMERLT FELGVAIDQY MVVFEDVKGT GAESKDLPSG HGINNLDSLR DYLDGSVKVN LEKKHLNKRT QIFPPGLVTM NEYPVPKTLQ ARFVRQIDFR PKIYLRKSLQ NSEFLLEKRI LQSGMTLLLL LIWFRPVADF ATDIQSRIVE WKERLDSEIS MYTFSRMKYN ICMGKCILDI TREEDSETED SGHGSSTESQ SQCSSQVSDT SAPDSDSQRS DPHSQELHLC KGFQCFKRPK TPPPK //