ID A0A852MPM2_9PASS Unreviewed; 448 AA. AC A0A852MPM2; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 25-MAY-2022, entry version 3. DE SubName: Full=CP39A hydroxylase {ECO:0000313|EMBL:NXY07382.1}; DE Flags: Fragment; GN Name=Cyp39a1 {ECO:0000313|EMBL:NXY07382.1}; GN ORFNames=PTEMEL_R14458 {ECO:0000313|EMBL:NXY07382.1}; OS Pteruthius melanotis. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Sylvioidea; Timaliidae; OC Pteruthius. OX NCBI_TaxID=357074 {ECO:0000313|EMBL:NXY07382.1, ECO:0000313|Proteomes:UP000603297}; RN [1] {ECO:0000313|EMBL:NXY07382.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=B10K-IZ-033-77 {ECO:0000313|EMBL:NXY07382.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971, CC ECO:0000256|PIRSR:PIRSR000047-1}; CC -!- SIMILARITY: Belongs to the cytochrome P450 family. CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NXY07382.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; WEIY01000383; NXY07382.1; -; Genomic_DNA. DR Proteomes; UP000603297; Unassembled WGS sequence. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro. DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. DR Gene3D; 1.10.630.10; -; 1. DR InterPro; IPR001128; Cyt_P450. DR InterPro; IPR017972; Cyt_P450_CS. DR InterPro; IPR024204; Cyt_P450_CYP7A1-type. DR InterPro; IPR002403; Cyt_P450_E_grp-IV. DR InterPro; IPR036396; Cyt_P450_sf. DR Pfam; PF00067; p450; 1. DR PIRSF; PIRSF000047; Cytochrome_CYPVIIA1; 1. DR PRINTS; PR00465; EP450IV. DR SUPFAM; SSF48264; SSF48264; 1. DR PROSITE; PS00086; CYTOCHROME_P450; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR000047-1}; KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000047-1}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022548}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR000047-1}; KW Monooxygenase {ECO:0000256|RuleBase:RU000461}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000461}; KW Reference proteome {ECO:0000313|Proteomes:UP000603297}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00022548}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00022548}. FT METAL 393 FT /note="Iron (heme axial ligand)" FT /evidence="ECO:0000256|PIRSR:PIRSR000047-1" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NXY07382.1" FT NON_TER 448 FT /evidence="ECO:0000313|EMBL:NXY07382.1" SQ SEQUENCE 448 AA; 51360 MW; 62E27AC64275EDF1 CRC64; LLFQLRNPSS PPCIRSWIPW FGAAFQFGKA PLEFIEQARN KHGPVFTIFA LGKRFTFVTE EEGTEAFFKS EDLNFEQAVQ QAVQNAVSVP AEAFYQNHGN LYSMMKGKMS PSNLHMFSGT LCKELHEHMA HLGTEGTGDL NDLVRHVMYP AVVNTLFGKG ICPTSQSEIK EFEEHFQKYD EDFEYASQMP ECFLRNWSKS KKWLLKLFEK VVLDAERTNP SEAASKTLLQ HLLDNLQGKH LAPNYGLLML WAAQANAVPV AFWTLAFILS NPAIYKKVME DLASVFGKAG KDKLEVSEED LKRMPFIKWC TLEAIRLRSP GAITKKVINP IRIKNFTIPA GDMLMLSPYW LHRNPKYFPD PEMFKPDRWK EANLEKNAFL DSFVAFGGGK HQCPGRWFAI MEIQLFVVLF LYKYEFVLLD AVPKESPLHL VGTQQPMAPL RVRYKCRE //