ID A0A850ZEM3_9PASS Unreviewed; 257 AA. AC A0A850ZEM3; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 24-JAN-2024, entry version 7. DE RecName: Full=1-acyl-sn-glycerol-3-phosphate acyltransferase delta {ECO:0000256|ARBA:ARBA00040981}; DE EC=2.3.1.51 {ECO:0000256|ARBA:ARBA00013211}; DE AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 4 {ECO:0000256|ARBA:ARBA00041272}; DE AltName: Full=Lysophosphatidic acid acyltransferase delta {ECO:0000256|ARBA:ARBA00042940}; DE Flags: Fragment; GN Name=Agpat4 {ECO:0000313|EMBL:NWH99569.1}; GN ORFNames=TICMUR_R03496 {ECO:0000313|EMBL:NWH99569.1}; OS Tichodroma muraria. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Sittidae; Tichodroma. OX NCBI_TaxID=237442 {ECO:0000313|EMBL:NWH99569.1, ECO:0000313|Proteomes:UP000629438}; RN [1] {ECO:0000313|EMBL:NWH99569.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=B10K-DU-012-47 {ECO:0000313|EMBL:NWH99569.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z- CC octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2- CC (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA; CC Xref=Rhea:RHEA:55312, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, CC ChEBI:CHEBI:74544, ChEBI:CHEBI:138723; CC Evidence={ECO:0000256|ARBA:ARBA00036892}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55313; CC Evidence={ECO:0000256|ARBA:ARBA00036892}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl- CC sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- CC docosahexaenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:55300, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57518, ChEBI:CHEBI:74298, CC ChEBI:CHEBI:82928; Evidence={ECO:0000256|ARBA:ARBA00035935}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55301; CC Evidence={ECO:0000256|ARBA:ARBA00035935}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl- CC sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z- CC docosahexaenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:55308, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:74565, CC ChEBI:CHEBI:77130; Evidence={ECO:0000256|ARBA:ARBA00036865}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55309; CC Evidence={ECO:0000256|ARBA:ARBA00036865}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3- CC phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- CC phosphate + CoA; Xref=Rhea:RHEA:55304, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57383, ChEBI:CHEBI:74565, ChEBI:CHEBI:77098; CC Evidence={ECO:0000256|ARBA:ARBA00036903}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55305; CC Evidence={ECO:0000256|ARBA:ARBA00036903}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl- CC sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:19709, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342, CC ChEBI:CHEBI:58608; EC=2.3.1.51; CC Evidence={ECO:0000256|ARBA:ARBA00000300}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19710; CC Evidence={ECO:0000256|ARBA:ARBA00000300}; CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP- CC diacylglycerol from sn-glycerol 3-phosphate: step 2/3. CC {ECO:0000256|ARBA:ARBA00004728}. CC -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate CC acyltransferase family. {ECO:0000256|ARBA:ARBA00008655}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWH99569.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; WAAG01025786; NWH99569.1; -; Genomic_DNA. DR AlphaFoldDB; A0A850ZEM3; -. DR Proteomes; UP000629438; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW. DR CDD; cd07990; LPLAT_LCLAT1-like; 1. DR InterPro; IPR032098; Acyltransf_C. DR InterPro; IPR002123; Plipid/glycerol_acylTrfase. DR PANTHER; PTHR10983:SF8; 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE DELTA; 1. DR PANTHER; PTHR10983; 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED; 1. DR Pfam; PF16076; Acyltransf_C; 1. DR Pfam; PF01553; Acyltransferase; 1. DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000313|EMBL:NWH99569.1}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023209}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209}; KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264}; KW Reference proteome {ECO:0000313|Proteomes:UP000629438}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:NWH99569.1}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 13..31 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 191..210 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 216..236 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 6..68 FT /note="Phospholipid/glycerol acyltransferase" FT /evidence="ECO:0000259|Pfam:PF01553" FT DOMAIN 127..194 FT /note="Acyltransferase C-terminal" FT /evidence="ECO:0000259|Pfam:PF16076" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWH99569.1" FT NON_TER 257 FT /evidence="ECO:0000313|EMBL:NWH99569.1" SQ SEQUENCE 257 AA; 30285 MW; 048842C73F324850 CRC64; ILQSSKVLAK KELSYMPIIG WMWYFLEIVF CKRKWEEDRK TVVQKLLNLR DYPENFWNAV EGTKSSRHKK KSWAEIRKKK KQNKKKPKQL IGFLTKRKGF QIFVFVSAVY DSTLNFRNNE NPTLLGVLNG KKYHADLYVR QDVPKDEQEC STWLHKLYQE KDAFQEEYYR TGTYPAVPTV PPRRPWTLLN WLFWALLLLY PLFKLLINMI NSGSSLTLAS FAFVIIIASI GVRWMIGVTE INKGSTYGNN DSKQKQK //