ID A0A850YVQ9_9PASS Unreviewed; 802 AA. AC A0A850YVQ9; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 22-FEB-2023, entry version 7. DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221}; DE Flags: Fragment; GN Name=Clcn7 {ECO:0000313|EMBL:NWH97662.1}; GN ORFNames=TICMUR_R02408 {ECO:0000313|EMBL:NWH97662.1}; OS Tichodroma muraria. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Sittidae; Tichodroma. OX NCBI_TaxID=237442 {ECO:0000313|EMBL:NWH97662.1, ECO:0000313|Proteomes:UP000629438}; RN [1] {ECO:0000313|EMBL:NWH97662.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=B10K-DU-012-47 {ECO:0000313|EMBL:NWH97662.1}; RA Zhang G.; RT "Bird 10,000 Genomes (B10K) Project - Family phase."; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}. CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. CC {ECO:0000256|RuleBase:RU361221}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NWH97662.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; WAAG01009473; NWH97662.1; -; Genomic_DNA. DR AlphaFoldDB; A0A850YVQ9; -. DR Proteomes; UP000629438; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule. DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1. DR CDD; cd03685; ClC_6_like; 1. DR Gene3D; 3.10.580.10; CBS-domain; 1. DR Gene3D; 1.10.3080.10; Clc chloride channel; 1. DR InterPro; IPR000644; CBS_dom. DR InterPro; IPR046342; CBS_dom_sf. DR InterPro; IPR014743; Cl-channel_core. DR InterPro; IPR001807; Cl-channel_volt-gated. DR InterPro; IPR002249; Cl_channel-7. DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1. DR PANTHER; PTHR11689:SF136; H(+)/CL(-) EXCHANGE TRANSPORTER 7; 1. DR Pfam; PF00571; CBS; 1. DR Pfam; PF00654; Voltage_CLC; 1. DR PRINTS; PR00762; CLCHANNEL. DR PRINTS; PR01118; CLCHANNEL7. DR SMART; SM00116; CBS; 2. DR SUPFAM; SSF54631; CBS-domain pair; 1. DR SUPFAM; SSF81340; Clc chloride channel; 1. DR PROSITE; PS51371; CBS; 1. PE 3: Inferred from homology; KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE- KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221}; KW Ion transport {ECO:0000256|RuleBase:RU361221}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221}; KW Reference proteome {ECO:0000313|Proteomes:UP000629438}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU361221}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}. FT TRANSMEM 123..144 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 172..193 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 223..241 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 284..307 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 319..341 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 371..395 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 484..503 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 509..531 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 543..567 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT TRANSMEM 573..594 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361221" FT DOMAIN 738..796 FT /note="CBS" FT /evidence="ECO:0000259|PROSITE:PS51371" FT REGION 1..43 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 9..24 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:NWH97662.1" FT NON_TER 802 FT /evidence="ECO:0000313|EMBL:NWH97662.1" SQ SEQUENCE 802 AA; 88435 MW; ABE1912B4FD82967 CRC64; MANVAKKVSW SGRDRDDDED GRAGETTPLL NGTGPGAAGS GRQLTPSSFL RIGQLSNVDL NEDICELETE VPRQRPNEIP HNEKLLSLKY ESLDYDNSEN QLFLEEERRI NHAAFRTVEI KRWVICAMIG ILTGLVACFI DIVVENLAGL KYRVVKDNID KFTAKGGLSF SLLLWATLNA SVVMVGSVIV AFIEPVAAGS GIPQIKCYLN GVKIPHVVRL KTLVIKVCGV ILSVVGGLAV GKEGPMIHSG SVIAAGISQG RSTSLKRDFK IFEYFRRDTE KRDFVSAGAA AGVSAAFGAP VGGVLFSLEE GASFWNQFLT WRIFFASMIS TFTLNSVLSV YHGNAWDLSS PGLINFGRFD SEKMGYTIQE IPIFIFMGVV GGILGALFNA LNYWLTMFRI RYIHRPCLQV VEAMLVAAVT ATVGFVMIYC SRDCQPIQGS SVAYPLQLFC ADGEYNSMAT AFFNTPEKSV VSLFHDPPGS YNPMTLGMFT LMYFFLACWT YGLTVSAGVF IPSLLIGAAW GRLFGISLSY LTKGSIWADP GKYALMGAAA QLGGIVRMTL SLTVIMMEAT GNVTYGFPIM LVLMTAKIVG DYFVEGLYDM HIQLQSVPFL HWEAPVTSHS LTAREVMSTP VTCLRRIERV GTVVDILSDT SSNHNGFPVV ESNPDTTQVA GLRGLILRSQ LIVLLKHKVF VERANLNLVQ RRLKLKDFRD AYPRFPPIQS IHVSQDEREC MIDLSEFMNP SPYTVPQEAS LPRVFKLFRA LGLRHLVVVD NRNEVVGMVT RKDLARYRLG KEGLEELSLA QT //