ID A0A849P248_HELPX Unreviewed; 314 AA. AC A0A849P248; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 19-JAN-2022, entry version 2. DE RecName: Full=Endolytic peptidoglycan transglycosylase RlpA {ECO:0000256|HAMAP-Rule:MF_02071}; DE EC=4.2.2.- {ECO:0000256|HAMAP-Rule:MF_02071}; GN Name=rlpA {ECO:0000256|HAMAP-Rule:MF_02071}; GN ORFNames=P740_005740 {ECO:0000313|EMBL:NOK31151.1}; OS Helicobacter pylori E48. OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=1400820 {ECO:0000313|EMBL:NOK31151.1, ECO:0000313|Proteomes:UP000551146}; RN [1] {ECO:0000313|EMBL:NOK31151.1, ECO:0000313|Proteomes:UP000551146} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=E48 {ECO:0000313|EMBL:NOK31151.1, RC ECO:0000313|Proteomes:UP000551146}; RA Butenko I., Fedorov D., Babenko V., Manolov A., Boldyreva D., Klimina K., RA Veselovski V., Malahova M., Semashko T., Semenov I., Govorun V.; RT "Proteome, Transcriptome, Methylome of different strains of Helicobacter RT pylori."; RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Lytic transglycosylase with a strong preference for naked CC glycan strands that lack stem peptides. {ECO:0000256|HAMAP- CC Rule:MF_02071}. CC -!- SIMILARITY: Belongs to the RlpA family. {ECO:0000256|HAMAP- CC Rule:MF_02071, ECO:0000256|RuleBase:RU003495}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:NOK31151.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AYHQ02000006; NOK31151.1; -; Genomic_DNA. DR Proteomes; UP000551146; Unassembled WGS sequence. DR Gene3D; 2.40.40.10; -; 1. DR Gene3D; 3.30.70.1070; -; 1. DR HAMAP; MF_02071; RlpA; 1. DR InterPro; IPR034718; RlpA. DR InterPro; IPR009009; RlpA-like_DPBB. DR InterPro; IPR036908; RlpA-like_sf. DR InterPro; IPR012997; RplA. DR InterPro; IPR007730; SPOR-like_dom. DR InterPro; IPR036680; SPOR-like_sf. DR Pfam; PF03330; DPBB_1; 1. DR Pfam; PF05036; SPOR; 1. DR SUPFAM; SSF110997; SSF110997; 1. DR SUPFAM; SSF50685; SSF50685; 1. DR TIGRFAMs; TIGR00413; rlpA; 1. DR PROSITE; PS51724; SPOR; 1. PE 3: Inferred from homology; KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316, KW ECO:0000256|HAMAP-Rule:MF_02071}; KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_02071}. FT DOMAIN 241..314 FT /note="SPOR" FT /evidence="ECO:0000259|PROSITE:PS51724" FT REGION 66..86 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 314 AA; 35305 MW; 497ECB16D841476B CRC64; MGLALKKVCF LGVIFLISAC AVKKEGIKNL SYKHESLRAY ENAKDYDPTT KKATYKRNFF ERHFKHHSDS QGNDTKQPLD NGMRDSSSIQ RATMRPYQVG GKWYYPTKVD LGEKFDGIAS WYGPNFHAKK TSNGEIYNMY AHTAAHKTLP MNTVVKVINV ENNLSTIVRI NDRGPFVSDR IIDLSNAAAR DIDMVKKGTA SVRLIVLGFG GVISKQYEQS FNASSSKILH KEFKVGESEK SVSGGKFSLQ MGAFRNQIGA QTLADKLQAE NPNYSVKVAF KDDLYKVLVQ GFQSEEEARD FMKKNNQNAV LTRE //