ID   A0A843IUF0_9EURY        Unreviewed;       325 AA.
AC   A0A843IUF0;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   25-MAY-2022, entry version 3.
DE   SubName: Full=Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:MBP5082656.1};
DE            EC=2.7.1.49 {ECO:0000313|EMBL:MBP5082656.1};
DE            EC=2.7.4.7 {ECO:0000313|EMBL:MBP5082656.1};
GN   Name=thiD {ECO:0000313|EMBL:MBP5082656.1};
GN   ORFNames=J6104_00260 {ECO:0000313|EMBL:MBP5082656.1};
OS   Methanomicrobium sp.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanomicrobium;
OC   unclassified Methanomicrobium.
OX   NCBI_TaxID=2052684 {ECO:0000313|EMBL:MBP5082656.1, ECO:0000313|Proteomes:UP000674441};
RN   [1] {ECO:0000313|EMBL:MBP5082656.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RGIG10369 {ECO:0000313|EMBL:MBP5082656.1};
RA   Xie F.;
RT   "A highly-resolved spatial and functional map of the ruminant
RT   gastrointestinal microbiome.";
RL   Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBP5082656.1}.
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DR   EMBL; JAGDDN010000011; MBP5082656.1; -; Genomic_DNA.
DR   Proteomes; UP000674441; Unassembled WGS sequence.
DR   GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR   CDD; cd01169; HMPP_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR045029; HMP/HMP-P_kinase.
DR   InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR   InterPro; IPR013749; PM/HMP-P_kinase-1.
DR   InterPro; IPR029056; Ribokinase-like.
DR   PANTHER; PTHR20858; PTHR20858; 1.
DR   Pfam; PF08543; Phos_pyr_kin; 2.
DR   SUPFAM; SSF53613; SSF53613; 1.
DR   TIGRFAMs; TIGR00097; HMP-P_kinase; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:MBP5082656.1};
KW   Transferase {ECO:0000313|EMBL:MBP5082656.1}.
FT   DOMAIN          29..210
FT                   /note="Phos_pyr_kin"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
FT   DOMAIN          252..306
FT                   /note="Phos_pyr_kin"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
SQ   SEQUENCE   325 AA;  33954 MW;  CDDC488D5FC4505F CRC64;
     MDSDTPSERQ NSRITGSAMP CACTIAGSDS GGGAGIQADL KTFAAFDVWG CSVITSLTAQ
     NPCTVLGIEN ASADFVGLQM RAVAGDFRIA AYKTGMLPTE DIIRTVAANI PESVPTVIDP
     VMISTSGSRL IDEDAAEALR SKLLPLAKMV TPNIPETCEL SGIDLSRNPS ETAIANAAEA
     ILDGGAEYVL IKGGHLSGDY STDYLISKDR EDRGEGVAAG DAVRDGWGEG GVSAGIRDDS
     RCRTEIKTGI NGLNIVKYTG PRFRGEIHGS GCCLSSAIAA CLAKEYCVER ACACAKVFIG
     DAIAGAYISE SKRYSINPGH PKKFL
//