ID A0A834DXL6_9CHIR Unreviewed; 784 AA. AC A0A834DXL6; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 08-NOV-2023, entry version 7. DE SubName: Full=Piwi like RNA-mediated gene silencing 2 protein {ECO:0000313|EMBL:KAF6096169.1}; GN ORFNames=HJG60_015029 {ECO:0000313|EMBL:KAF6096169.1}; OS Phyllostomus discolor (pale spear-nosed bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae; OC Phyllostominae; Phyllostomus. OX NCBI_TaxID=89673 {ECO:0000313|EMBL:KAF6096169.1, ECO:0000313|Proteomes:UP000664940}; RN [1] {ECO:0000313|EMBL:KAF6096169.1, ECO:0000313|Proteomes:UP000664940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bat1K_MPI-CBG_1 {ECO:0000313|EMBL:KAF6096169.1}; RX PubMed=32699395; RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P., RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L., RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M., RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N., RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M., RA Vernes S.C., Myers E.W., Teeling E.C.; RT "Six reference-quality genomes reveal evolution of bat adaptations."; RL Nature 583:578-584(2020). CC -!- SIMILARITY: Belongs to the argonaute family. CC {ECO:0000256|RuleBase:RU361178}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAF6096169.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JABVXQ010000008; KAF6096169.1; -; Genomic_DNA. DR AlphaFoldDB; A0A834DXL6; -. DR Proteomes; UP000664940; Unassembled WGS sequence. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW. DR CDD; cd02845; PAZ_piwi_like; 1. DR CDD; cd04658; Piwi_piwi-like_Euk; 1. DR Gene3D; 3.40.50.2300; -; 1. DR Gene3D; 2.170.260.10; paz domain; 1. DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1. DR InterPro; IPR014811; ArgoL1. DR InterPro; IPR003100; PAZ_dom. DR InterPro; IPR036085; PAZ_dom_sf. DR InterPro; IPR003165; Piwi. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1. DR PANTHER; PTHR22891:SF111; PIWI-LIKE PROTEIN 2; 1. DR Pfam; PF08699; ArgoL1; 1. DR Pfam; PF02170; PAZ; 1. DR Pfam; PF02171; Piwi; 1. DR SMART; SM01163; DUF1785; 1. DR SMART; SM00949; PAZ; 1. DR SMART; SM00950; Piwi; 1. DR SUPFAM; SSF101690; PAZ domain; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR PROSITE; PS50821; PAZ; 1. DR PROSITE; PS50822; PIWI; 1. PE 3: Inferred from homology; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}; KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}. FT DOMAIN 199..307 FT /note="PAZ" FT /evidence="ECO:0000259|PROSITE:PS50821" FT DOMAIN 479..770 FT /note="Piwi" FT /evidence="ECO:0000259|PROSITE:PS50822" SQ SEQUENCE 784 AA; 89933 MW; 87EECFC054558B6F CRC64; MGLFVCLFVF GMCGCFCFLF SRELFMKQGS KGKPQPLGLN LIKIQCHNEA VYQYHVTFSP NVECKSMRFG MLKDHQAVTG NVTAFDGSIL YLPVKLQQVL ELKSQRKTDG AEISIKIQLT KILEPCSDLC IPFYNVVFRR VMKLLDMKLV GRNFYDPTNA MVLQQHRLQI WPGYAASIRR TDGGLFLLAD VSHKVIRNDS VLNVMHAIYQ QDKENFQDEC TKLLVGNIVI TRYNNRTYRI DDVDWNKTPK DTFTLSDGKE ITFLEYYSKN YGITIKEEEQ PLLIHRPSER QNSQGTLLKG EILLLPELSF MTGIPEKMKK DYRAMKDLTQ HINLSPKQHH SALECLIQKI SKNETANNEL TRWGLYLQND VHKIEGRVLP MERINLRNTS FITSQEVNWT KEVTRDLSIL TVPMHFWALF YPKRAMDQAR ELVSMLEKIA GPIGMRMSPP AWVELKDDRT ETYVRTIQSM LRAEGKIQMV VCIIMGTRDD LYGAIKKLCC VQAPVPSQVI NARTIGQPTK LRSVAQKILL QINCKLGGEL WGVDIPLKQL MVIGMDVYHD PSRGMRSVVG FVASINLTLT KWFSRVVFQM PHQEIVDSLK LCLVGSLKKF YEVNHCLPEK IVVYRDGVSD GQLRTVANYE IPQLQKCFEA FENYQPKMVV FVVQKKISTN LYLAATEHFA TPSPGTVVDH TITSCDWVDF YLLAHHVRQG CGIPTHYVCV LNTANLSPDH MQRLTFKLCH MYWNWPGTIR VPAPCKYAHK LAFLSGQILH HEPAIQLCEN LFFL //