ID A0A834ACV4_9CHIR Unreviewed; 665 AA. AC A0A834ACV4; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 27-MAR-2024, entry version 9. DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044}; DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044}; GN ORFNames=HJG60_006797 {ECO:0000313|EMBL:KAF6109163.1}; OS Phyllostomus discolor (pale spear-nosed bat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae; OC Phyllostominae; Phyllostomus. OX NCBI_TaxID=89673 {ECO:0000313|EMBL:KAF6109163.1, ECO:0000313|Proteomes:UP000664940}; RN [1] {ECO:0000313|EMBL:KAF6109163.1, ECO:0000313|Proteomes:UP000664940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bat1K_MPI-CBG_1 {ECO:0000313|EMBL:KAF6109163.1}; RX PubMed=32699395; RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P., RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L., RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M., RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N., RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M., RA Vernes S.C., Myers E.W., Teeling E.C.; RT "Six reference-quality genomes reveal evolution of bat adaptations."; RL Nature 583:578-584(2020). CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane CC {ECO:0000256|ARBA:ARBA00004608}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase CC type II family. {ECO:0000256|ARBA:ARBA00005910}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAF6109163.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JABVXQ010000005; KAF6109163.1; -; Genomic_DNA. DR AlphaFoldDB; A0A834ACV4; -. DR Proteomes; UP000664940; Unassembled WGS sequence. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro. DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd09093; INPP5c_INPP5B; 1. DR CDD; cd04380; RhoGAP_OCRL1; 1. DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1. DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR046985; IP5. DR InterPro; IPR000300; IPPc. DR InterPro; IPR048869; OCRL-1_2_ASH. DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c. DR InterPro; IPR008936; Rho_GTPase_activation_prot. DR InterPro; IPR000198; RhoGAP_dom. DR InterPro; IPR047078; RhoGAP_OCRL1. DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1. DR PANTHER; PTHR11200:SF163; TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE; 1. DR Pfam; PF21310; OCRL-like_ASH; 1. DR Pfam; PF00620; RhoGAP; 1. DR SMART; SM00128; IPPc; 1. DR SMART; SM00324; RhoGAP; 1. DR SUPFAM; SSF56219; DNase I-like; 1. DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1. DR PROSITE; PS50238; RHOGAP; 1. PE 3: Inferred from homology; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}. FT DOMAIN 490..665 FT /note="Rho-GAP" FT /evidence="ECO:0000259|PROSITE:PS50238" SQ SEQUENCE 665 AA; 76635 MW; FF46868D8F364591 CRC64; MNDMIRCSTI TVSDKAHILS MQKFGLRDTI VKSHLMQKEE DYTNIQNFSF QELDLSKEAF FFHDTPKEEE WFKVVSESLH PDAKYAKVKL IRLVGIMLLL YVKQEHAAHV SEVEAETVGT GIMGRMGNKG GVAIRFQFHN TSICVVNSHL AAHTEEYERR NQDYKDICSR MQFCQVDPSL PPLTISKHDV ILWLGDLNYR IEELDVEKVK KLIEEKAFQT LHAYDQLKIQ VAAKAVFEGF TEGELTFQPT YKYDTGSDEW DTSEKCRAPA WCDRILWKGK NITQLSYQSH MALKTSDHKP VSSEFDIGVR VKDEDLYRKT LEEIVRSLDK MENANIPSVS LSKREFCFQD VKYMQLQVES FTILNGQVPC QFEFINKPDE ESYCKPWLNV NPSRGFLLPE SSIEIELEVF VNKTMATKLN SGEDKIEDIL VLHLDRGKDY FLSVSGNYLP GCFGTPIHTL CYMREPILDL PLETVRELTL MPLCTEDGGS QLEKPMEIPK ELWMMVDYLY RNAVQQEDLF QQPGLRLEFE KIRDSLDTGM IDTLDILSIN NHSVAEALLL FLESLPEPVI CYSAYHNCLE CSGNYTASKQ VISTLPTFHR NVFYYLMAFL QELLKNSEKN HLDQNILASI FGSLLLRNPA GHQKLEMAEK KKAQEFIHQF LCNSL //