ID   A0A832Z448_9EURY        Unreviewed;       266 AA.
AC   A0A832Z448;
DT   29-SEP-2021, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 1.
DT   27-NOV-2024, entry version 9.
DE   RecName: Full=Hydroxyethylthiazole kinase {ECO:0000256|HAMAP-Rule:MF_00228};
DE            EC=2.7.1.50 {ECO:0000256|HAMAP-Rule:MF_00228};
DE   AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase {ECO:0000256|HAMAP-Rule:MF_00228};
DE            Short=TH kinase {ECO:0000256|HAMAP-Rule:MF_00228};
DE            Short=Thz kinase {ECO:0000256|HAMAP-Rule:MF_00228};
GN   Name=thiM {ECO:0000256|HAMAP-Rule:MF_00228};
GN   ORFNames=EYH13_00300 {ECO:0000313|EMBL:HIP74615.1};
OS   Thermococcus paralvinellae.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=582419 {ECO:0000313|EMBL:HIP74615.1, ECO:0000313|Proteomes:UP000649326};
RN   [1] {ECO:0000313|EMBL:HIP74615.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SZUA-1451 {ECO:0000313|EMBL:HIP74615.1};
RX   PubMed=32820229;
RA   Zhou Z., Liu Y., Pan J., Cron B.R., Toner B.M., Anantharaman K.,
RA   Breier J.A., Dick G.J., Li M.;
RT   "Gammaproteobacteria mediating utilization of methyl-, sulfur- and
RT   petroleum organic compounds in deep ocean hydrothermal plumes.";
RL   ISME J. 14:3136-3148(2020).
CC   -!- FUNCTION: Catalyzes the phosphorylation of the hydroxyl group of 4-
CC       methyl-5-beta-hydroxyethylthiazole (THZ). {ECO:0000256|HAMAP-
CC       Rule:MF_00228}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-
CC         phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=2.7.1.50;
CC         Evidence={ECO:0000256|ARBA:ARBA00001771, ECO:0000256|HAMAP-
CC         Rule:MF_00228};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946,
CC         ECO:0000256|HAMAP-Rule:MF_00228};
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-
CC       methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-
CC       methylthiazole: step 1/1. {ECO:0000256|ARBA:ARBA00004868,
CC       ECO:0000256|HAMAP-Rule:MF_00228}.
CC   -!- SIMILARITY: Belongs to the Thz kinase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:HIP74615.1}.
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DR   EMBL; DQUG01000012; HIP74615.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A832Z448; -.
DR   UniPathway; UPA00060; UER00139.
DR   Proteomes; UP000649326; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004417; F:hydroxyethylthiazole kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01170; THZ_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   HAMAP; MF_00228; Thz_kinase; 1.
DR   InterPro; IPR000417; Hyethyz_kinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   NCBIfam; TIGR00694; thiM; 1.
DR   Pfam; PF02110; HK; 1.
DR   PIRSF; PIRSF000513; Thz_kinase; 1.
DR   PRINTS; PR01099; HYETHTZKNASE.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00228};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|HAMAP-Rule:MF_00228};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00228};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00228};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00228};
KW   Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977, ECO:0000256|HAMAP-
KW   Rule:MF_00228};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00228, ECO:0000313|EMBL:HIP74615.1}.
FT   BINDING         43
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00228"
FT   BINDING         119
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00228"
FT   BINDING         166
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00228"
FT   BINDING         193
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00228"
SQ   SEQUENCE   266 AA;  28810 MW;  4401A155F662E8F8 CRC64;
     MGWVAQALEK VRKRKPLVQN ITNFVVMNTT ANALLAIGAS PVMAHAREEL EDMLRIADSL
     VINIGTLDEH WIASMEKAVK IASELKKPTV LDPVGAGATK LRTETALKLL DMGSVTILRG
     NFGEIASLLG EHGKTRGVDS AAYEKDRAKE LAFIAAKEFN TVVAVTGPVD YVSDGEEVYA
     VYNGHEMLGR VTGTGCMVTA ITGAFAAVEE PLKAAVSSLV VFGIAAEKAY EEAKYPGSFH
     VKLYDWLYRI DGELINKMGR VRKVEP
//