ID A0A832Z448_9EURY Unreviewed; 266 AA. AC A0A832Z448; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 03-AUG-2022, entry version 4. DE RecName: Full=Hydroxyethylthiazole kinase {ECO:0000256|HAMAP-Rule:MF_00228}; DE EC=2.7.1.50 {ECO:0000256|HAMAP-Rule:MF_00228}; DE AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase {ECO:0000256|HAMAP-Rule:MF_00228}; DE Short=TH kinase {ECO:0000256|HAMAP-Rule:MF_00228}; DE Short=Thz kinase {ECO:0000256|HAMAP-Rule:MF_00228}; GN Name=thiM {ECO:0000256|HAMAP-Rule:MF_00228}; GN ORFNames=EYH13_00300 {ECO:0000313|EMBL:HIP74615.1}; OS Thermococcus paralvinellae. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Thermococcus. OX NCBI_TaxID=582419 {ECO:0000313|EMBL:HIP74615.1, ECO:0000313|Proteomes:UP000649326}; RN [1] {ECO:0000313|EMBL:HIP74615.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SZUA-1451 {ECO:0000313|EMBL:HIP74615.1}; RX PubMed=32820229; RA Zhou Z., Liu Y., Pan J., Cron B.R., Toner B.M., Anantharaman K., RA Breier J.A., Dick G.J., Li M.; RT "Gammaproteobacteria mediating utilization of methyl-, sulfur- and RT petroleum organic compounds in deep ocean hydrothermal plumes."; RL ISME J. 14:3136-3148(2020). CC -!- FUNCTION: Catalyzes the phosphorylation of the hydroxyl group of 4- CC methyl-5-beta-hydroxyethylthiazole (THZ). {ECO:0000256|HAMAP- CC Rule:MF_00228}. CC -!- CATALYTIC ACTIVITY: CC Reaction=5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2- CC phosphooxyethyl)-thiazole + ADP + H(+); Xref=Rhea:RHEA:24212, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17957, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:58296, ChEBI:CHEBI:456216; EC=2.7.1.50; CC Evidence={ECO:0000256|ARBA:ARBA00001771, ECO:0000256|HAMAP- CC Rule:MF_00228}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946, CC ECO:0000256|HAMAP-Rule:MF_00228}; CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4- CC methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4- CC methylthiazole: step 1/1. {ECO:0000256|ARBA:ARBA00004868, CC ECO:0000256|HAMAP-Rule:MF_00228}. CC -!- SIMILARITY: Belongs to the Thz kinase family. {ECO:0000256|HAMAP- CC Rule:MF_00228}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:HIP74615.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQUG01000012; HIP74615.1; -; Genomic_DNA. DR UniPathway; UPA00060; UER00139. DR Proteomes; UP000649326; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004417; F:hydroxyethylthiazole kinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd01170; THZ_kinase; 1. DR Gene3D; 3.40.1190.20; -; 1. DR HAMAP; MF_00228; Thz_kinase; 1. DR InterPro; IPR000417; Hyethyz_kinase. DR InterPro; IPR029056; Ribokinase-like. DR Pfam; PF02110; HK; 1. DR PIRSF; PIRSF000513; Thz_kinase; 1. DR PRINTS; PR01099; HYETHTZKNASE. DR SUPFAM; SSF53613; SSF53613; 1. DR TIGRFAMs; TIGR00694; thiM; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00228}; KW Kinase {ECO:0000256|HAMAP-Rule:MF_00228, ECO:0000313|EMBL:HIP74615.1}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00228}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_00228}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00228}; KW Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977, ECO:0000256|HAMAP- KW Rule:MF_00228}; KW Transferase {ECO:0000256|HAMAP-Rule:MF_00228, ECO:0000313|EMBL:HIP74615.1}. FT BINDING 43 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00228" FT BINDING 119 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00228" FT BINDING 166 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00228" FT BINDING 193 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00228" SQ SEQUENCE 266 AA; 28810 MW; 4401A155F662E8F8 CRC64; MGWVAQALEK VRKRKPLVQN ITNFVVMNTT ANALLAIGAS PVMAHAREEL EDMLRIADSL VINIGTLDEH WIASMEKAVK IASELKKPTV LDPVGAGATK LRTETALKLL DMGSVTILRG NFGEIASLLG EHGKTRGVDS AAYEKDRAKE LAFIAAKEFN TVVAVTGPVD YVSDGEEVYA VYNGHEMLGR VTGTGCMVTA ITGAFAAVEE PLKAAVSSLV VFGIAAEKAY EEAKYPGSFH VKLYDWLYRI DGELINKMGR VRKVEP //