ID A0A829RRV6_9GAMM Unreviewed; 267 AA. AC A0A829RRV6; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 03-AUG-2022, entry version 4. DE SubName: Full=Aldo/keto reductase family protein {ECO:0000313|EMBL:EXR17681.1}; GN ORFNames=J671_2010 {ECO:0000313|EMBL:EXR17681.1}; OS Acinetobacter sp. 1130196. OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae; OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex. OX NCBI_TaxID=1310772 {ECO:0000313|EMBL:EXR17681.1, ECO:0000313|Proteomes:UP000020533}; RN [1] {ECO:0000313|EMBL:EXR17681.1, ECO:0000313|Proteomes:UP000020533} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1130196 {ECO:0000313|EMBL:EXR17681.1, RC ECO:0000313|Proteomes:UP000020533}; RA Harris A.D., Johnson K.J., George J., Nadendla S., Daugherty S.C., RA Parankush S., Sadzewicz L., Tallon L., Sengamalay N., Hazen T.H., RA Rasko D.A.; RT "Comparative genomics and transcriptomics to identify genetic mechanisms RT underlying the emergence of carbapenem resistant Acinetobacter baumannii RT (CRAb)."; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EXR17681.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JFWX01000019; EXR17681.1; -; Genomic_DNA. DR RefSeq; WP_004885055.1; NZ_JFWX01000019.1. DR Proteomes; UP000020533; Unassembled WGS sequence. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR Gene3D; 3.20.20.100; -; 1. DR InterPro; IPR020471; AKR. DR InterPro; IPR018170; Aldo/ket_reductase_CS. DR InterPro; IPR023210; NADP_OxRdtase_dom. DR InterPro; IPR036812; NADP_OxRdtase_dom_sf. DR PANTHER; PTHR43827; PTHR43827; 1. DR Pfam; PF00248; Aldo_ket_red; 1. DR PIRSF; PIRSF000097; AKR; 2. DR PRINTS; PR00069; ALDKETRDTASE. DR SUPFAM; SSF51430; SSF51430; 1. DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1. DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1. PE 4: Predicted; FT DOMAIN 11..251 FT /note="Aldo_ket_red" FT /evidence="ECO:0000259|Pfam:PF00248" FT ACT_SITE 39 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1" FT BINDING 97 FT /ligand="substrate" FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2" FT SITE 64 FT /note="Lowers pKa of active site Tyr" FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3" SQ SEQUENCE 267 AA; 29672 MW; 4BDF7FA253B31E50 CRC64; MNIPRFGLGT FRLKEQAVID SVKNALDVGY RAIDTAQIYE NEAAIGQAIA ESGVSRQDLF LTTKIWVDNF AQEKFIPSLK ESLQKLRTDH VDLTLIHWPA PDLGVSIPEV MQLLLEAKQQ GLTKQIGISN FNIALTQQAI DTIGVEHIAT NQIELSPYLQ NHKLVNFLQE KNIDVTSYMT LAYGKVLHDP VLAEIAAANK ASTAQIALAW ALQRGFAVIP SSTKRENLIS NLKAQDIELT SAEMQMIAEL DRNGREVSPE PWAPVWD //