ID A0A828TMA6_STREE Unreviewed; 303 AA. AC A0A828TMA6; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 19-JAN-2022, entry version 2. DE RecName: Full=Tagatose-6-phosphate kinase {ECO:0000256|PIRNR:PIRNR000535}; DE EC=2.7.1.144 {ECO:0000256|PIRNR:PIRNR000535}; GN Name=pfkB {ECO:0000313|EMBL:EHD59909.1}; GN ORFNames=SPAR70_0804 {ECO:0000313|EMBL:EHD59909.1}; OS Streptococcus pneumoniae GA41410. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=760811 {ECO:0000313|EMBL:EHD59909.1, ECO:0000313|Proteomes:UP000003388}; RN [1] {ECO:0000313|EMBL:EHD59909.1, ECO:0000313|Proteomes:UP000003388} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GA41410 {ECO:0000313|EMBL:EHD59909.1, RC ECO:0000313|Proteomes:UP000003388}; RA Chancey S., Kumar N., Sengamalay N., Matthews C., Hine E., Pallavajjal A., RA Abolude O., Daugherty S.C., Sadzewicz L., Tallon L.J., Farley M.M., RA Baughman W., McGee L., Stephens D.S., Tettelin H.; RT "Genomic Sequence of Streptococcus pneumoniae GA41410."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose CC 1,6-bisphosphate + H(+); Xref=Rhea:RHEA:12420, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58694, ChEBI:CHEBI:58695, CC ChEBI:CHEBI:456216; EC=2.7.1.144; CC Evidence={ECO:0000256|PIRNR:PIRNR000535}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6- CC bisphosphate + H(+); Xref=Rhea:RHEA:14213, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:138881, CC ChEBI:CHEBI:456216; EC=2.7.1.56; CC Evidence={ECO:0000256|ARBA:ARBA00000823}; CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation; CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6- CC phosphate: step 1/2. {ECO:0000256|PIRNR:PIRNR000535}. CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family. LacC CC subfamily. {ECO:0000256|PIRNR:PIRNR000535}. CC -!- SIMILARITY: Belongs to the carbohydrate kinase pfkB family. CC {ECO:0000256|ARBA:ARBA00005380}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EHD59909.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AGOJ01000011; EHD59909.1; -; Genomic_DNA. DR UniPathway; UPA00704; UER00715. DR Proteomes; UP000003388; Unassembled WGS sequence. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR CDD; cd01164; FruK_PfkB_like; 1. DR Gene3D; 3.40.1190.20; -; 1. DR InterPro; IPR022463; 1-PFruKinase. DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS. DR InterPro; IPR011611; PfkB_dom. DR InterPro; IPR029056; Ribokinase-like. DR InterPro; IPR017583; Tagatose/fructose_Pkinase. DR Pfam; PF00294; PfkB; 1. DR PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1. DR SUPFAM; SSF53613; SSF53613; 1. DR TIGRFAMs; TIGR03168; 1-PFK; 1. DR TIGRFAMs; TIGR03828; pfkB; 1. DR PROSITE; PS00584; PFKB_KINASES_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRNR:PIRNR000535}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EHD59909.1}; KW Lactose metabolism {ECO:0000256|PIRNR:PIRNR000535}; KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000535}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000535}. FT DOMAIN 7..280 FT /note="PfkB" FT /evidence="ECO:0000259|Pfam:PF00294" SQ SEQUENCE 303 AA; 32651 MW; 25A21A320097C547 CRC64; MIYTVTLNPS IDYIVRLDQV KVGSVNRMDS DDKFAGGKGI NVSRVLKRLN IPNTATGFIG GFTGKFITDT LAEEEIETRF VQVAEDTRIN VKIKADQETE INGTGPTVEP VKLEELKAIL SSLTAEDTVV FAGSSAKNLG NVIYKDLISL TRQTGAQVVC DFEGQTLIDS LDYQPLLVKP NNHELGAIFG VKLESLDEIE KYARELLAKG AQNVIISMAG DGALLVTSEG AYFAKPIKGT VKNSVGAGDS MVAGFTGEFV KSKDAVEAFK WGVACGTATT FSDDLATAEF IKETYGKVEV EKR //