ID A0A811BIT5_MOUSE Unreviewed; 253 AA. AC A0A811BIT5; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 27-NOV-2024, entry version 9. DE SubName: Full=Claudin domain containing 1, isoform CRA_b {ECO:0000313|EMBL:EDK98187.1}; DE SubName: Full=Claudin-25 {ECO:0000313|EMBL:BCT97389.1}; GN Name=Cldnd1 {ECO:0000313|EMBL:EDK98187.1, GN ECO:0000313|MGI:MGI:2447860}; GN Synonyms=CLDN25 {ECO:0000313|EMBL:BCT97389.1}; GN ORFNames=mCG_127941 {ECO:0000313|EMBL:EDK98187.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BCT97389.1}; RN [1] {ECO:0000313|EMBL:EDK98187.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDK98187.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., RA Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., RA Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., RA Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., RA Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., RA Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., RA Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., RA Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., RA Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., RA Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., RA Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., RA Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., RA Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., RA Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., RA Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., RA Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., RA MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., RA Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., RA Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., RA Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., RA Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., RA Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., RA Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., RA Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the RT human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:EDK98187.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDK98187.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:BCT97389.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BCT97389.1}; RX DOI=10.1016/j.febslet.2011.01.028; RA Mineta K., Yamamoto Y., Yamasaki Y., Tanaka H., Tada Y., Saito K., RA Tamura A., Igarashi M., Endo T., Takeuchi K., Tsukita S.; RT "Predicted expansion of the claudin multigene family."; RL FEBS Lett. 585:606-612(2011). RN [4] {ECO:0000313|EMBL:BCT97389.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:BCT97389.1}; RC TISSUE=Brain and testis {ECO:0000313|EMBL:BCT97389.1}; RA Mineta K., Takeuchi K., Tsukita S.; RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC621341; BCT97389.1; -; mRNA. DR EMBL; CH466521; EDK98187.1; -; Genomic_DNA. DR EMBL; CH466521; EDK98188.1; -; Genomic_DNA. DR EMBL; CH466521; EDK98191.1; -; Genomic_DNA. DR RefSeq; NP_741968.1; NM_171826.3. DR RefSeq; XP_006522157.1; XM_006522094.3. DR AlphaFoldDB; A0A811BIT5; -. DR GeneID; 224250; -. DR KEGG; mmu:224250; -. DR AGR; MGI:2447860; -. DR CTD; 56650; -. DR MGI; MGI:2447860; Cldnd1. DR OMA; NTHWYSP; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR FunFam; 1.20.140.150:FF:000009; Claudin domain-containing protein 1; 1. DR Gene3D; 1.20.140.150; -; 1. DR InterPro; IPR042356; CLDN1. DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin. DR PANTHER; PTHR14347; CLAUDIN DOMAIN-CONTAINING PROTEIN 1; 1. DR PANTHER; PTHR14347:SF3; CLAUDIN DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF13903; Claudin_2; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 6..27 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 141..168 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 174..195 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 216..237 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 253 AA; 28572 MW; 46C1C28B0AFAC852 CRC64; MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPIQ ENSSDSNKIA WEDFLGDEAD EKTYNDVLFR YNGSLGLWRR CITIPKNTHW YAPPERTESF DVVTKCMSFT LNEQFMEKYV DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL MCFGALIGLC ACICRSLYPT LATGILHLLA GLCTLGSVSC YVAGIELLHQ KVELPKDVSG EFGWSFCLAC VSAPLQFMAA ALFIWAAHTN RKEYTLMKAY RVA //