ID A0A804HIT4_HUMAN Unreviewed; 965 AA. AC A0A804HIT4; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 14-DEC-2022, entry version 5. DE SubName: Full=Eukaryotic translation initiation factor 2-alpha kinase 3 {ECO:0000313|Ensembl:ENSP00000507214.1}; GN Name=EIF2AK3 {ECO:0000313|Ensembl:ENSP00000507214.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000507214.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000507214.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000507214.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004115}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC062029; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC104134; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001300844.1; NM_001313915.1. DR AlphaFoldDB; A0A804HIT4; -. DR SMR; A0A804HIT4; -. DR PeptideAtlas; A0A804HIT4; -. DR Ensembl; ENST00000682892.1; ENSP00000507214.1; ENSG00000172071.15. DR GeneID; 9451; -. DR CTD; 9451; -. DR HGNC; HGNC:3255; EIF2AK3. DR GeneTree; ENSGT00940000158121; -. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000172071; Expressed in body of pancreas and 197 other tissues. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro. DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt. DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt. DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt. DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:UniProt. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 2. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; KW Proteomics identification {ECO:0007829|EPD:A0A804HIT4, KW ECO:0007829|MaxQB:A0A804HIT4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 442..926 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 399..420 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 690..712 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 939..965 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 471 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 965 AA; 109916 MW; F569903EAD5E681E CRC64; MIIPSLDGAL FQWDQDRESM ETVPFTVESL LESSYKFGDD VVLVGGKSLT TYGLSAYSGK VRYICSALGC RQWDSDEMEQ EEDILLLQRT QKTVRAVGPR SGNEKWNFSV GHFELRYIPD METRAGFIES TFKPNENTEE SKIISDVEEQ EAAIMDIVIK VSVADWKVMA FSKKGGHLEW EYQFCTPIAS AWLLKDGKVI PISLFDDTSY TSNDDVLEDE EDIVEAARGA TENSVYLGMY RGQLYLQSSV RISEKFPSSP KALESVTNEN AIIPLPTIKW KPLIHSPSRT PVLVGSDEFD KCLSNDKFSH EEYSNGALSI LQYPYDNGYY LPYYKRERNK RSTQITVRFL DNPHYNKNIR KKDPVLLLHW WKEIVATILF CIIATTFIVR RLFHPHPHRQ RKESETQCQT ENKYDSVSGE ANDSSWNDIK NSGYISRYLT DFEPIQCLGR GGFGVVFEAK NKVDDCNYAI KRIRLPNREL AREKVMREVK ALAKLEHPGI VRYFNAWLEA PPEKWQEKMD EIWLKDESTD WPLSSPSPMD APSVKIRRMD PFATKEHIEI IAPSPQRSRS FSVGISCDQT SSSESQFSPL EFSGMDHEDI SESVDAAYNL QDSCLTDCDV EDGTMDGNDE GHSFELCPSE ASPYVRSRER TSSSIVFEDS GCDNASSKEE PKTNRLHIGN HCANKLTAFK PTSSKSSSEA TLSISPPRPT TLSLDLTKNT TEKLQPSSPK VYLYIQMQLC RKENLKDWMN GRCTIEERER SVCLHIFLQI AEAVEFLHSK GLMHRDLKPS NIFFTMDDVV KVGDFGLVTA MDQDEEEQTV LTPMPAYARH TGQVGTKLYM SPEQIHGNSY SHKVDIFSLG LILFELLYPF STQMERVRTL TDVRNLKFPP LFTQKYPCEY VMVQDMLSPS PMERPEAINI IENAVFEDLD FPGKTVLRQR SRSLSSSGTK HSRQSNNSHS PLPSN //