ID A0A803U1G8_ANOCA Unreviewed; 817 AA. AC A0A803U1G8; DT 29-SEP-2021, integrated into UniProtKB/TrEMBL. DT 29-SEP-2021, sequence version 1. DT 13-SEP-2023, entry version 10. DE SubName: Full=Piwi like RNA-mediated gene silencing 4 {ECO:0000313|Ensembl:ENSACAP00000041308.1}; GN Name=PIWIL4 {ECO:0000313|Ensembl:ENSACAP00000041308.1}; OS Anolis carolinensis (Green anole) (American chameleon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; OC Iguania; Dactyloidae; Anolis. OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000041308.1, ECO:0000313|Proteomes:UP000001646}; RN [1] {ECO:0000313|Ensembl:ENSACAP00000041308.1, ECO:0000313|Proteomes:UP000001646} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000041308.1, RC ECO:0000313|Proteomes:UP000001646}; RG The Genome Sequencing Platform; RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J., RA Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard)."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSACAP00000041308.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the argonaute family. CC {ECO:0000256|RuleBase:RU361178}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A803U1G8; -. DR Ensembl; ENSACAT00000039690.1; ENSACAP00000041308.1; ENSACAG00000014070.4. DR GeneTree; ENSGT00950000183200; -. DR Proteomes; UP000001646; Chromosome 3. DR Bgee; ENSACAG00000014070; Expressed in dewlap and 5 other tissues. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. DR GO; GO:0031047; P:RNA-mediated gene silencing; IEA:UniProtKB-KW. DR CDD; cd02845; PAZ_piwi_like; 1. DR CDD; cd04658; Piwi_piwi-like_Euk; 1. DR Gene3D; 3.40.50.2300; -; 1. DR Gene3D; 2.170.260.10; paz domain; 1. DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1. DR InterPro; IPR032474; Argonaute_N. DR InterPro; IPR003100; PAZ_dom. DR InterPro; IPR036085; PAZ_dom_sf. DR InterPro; IPR003165; Piwi. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1. DR PANTHER; PTHR22891:SF43; PIWI-LIKE PROTEIN 4; 1. DR Pfam; PF16486; ArgoN; 1. DR Pfam; PF02170; PAZ; 1. DR Pfam; PF02171; Piwi; 1. DR SMART; SM00949; PAZ; 1. DR SMART; SM00950; Piwi; 1. DR SUPFAM; SSF101690; PAZ domain; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR PROSITE; PS50821; PAZ; 1. DR PROSITE; PS50822; PIWI; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000001646}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}; KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}. FT DOMAIN 284..372 FT /note="PAZ" FT /evidence="ECO:0000259|PROSITE:PS50821" FT DOMAIN 511..803 FT /note="Piwi" FT /evidence="ECO:0000259|PROSITE:PS50822" FT REGION 1..34 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..15 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 817 AA; 92762 MW; EC67543D96735C65 CRC64; FIPSITPQGY SGSSGPLALE SGRDDGSSHT RAGNSPPKCK CMISLFGFSA GSAGYKVMDR GGKIRCNFSD MGVNTREKME HVRDSKTGSS GIPVKVVTNL FGLSMPREWQ LYQYHVKFNP ELESKRLKAA LVYNHPVFKG KPVVFDGVST LFLAHKQENE VTELFCETQR GETVKIIITL THQLQSSSPV SIQFLNVTFK KVLKKLSMHQ IGQNFYSPSD PVEIPQHKLT LWPGFAVSVG QYENRVMVCA DVSHKVLRNE SVLEFMTSLY QNVDRARFPE MCEKELVGLI VLTRYNNKTY RIDDIEWSVK ATDSFEKRDG TQITYEQYYK QQYDLVLTDL NQPMLVSELK KGRNIDKPRV VHLVPELCYM TGLSSRAKSN FHLMKDLAQE MHLSPETRHQ RLSRLADNIQ RLLSEFAFPL FLILQCMPMN AGDWLRDMRN MKIIRVARLE NWMVVCTHRN MDMTHDLVNC LRRVGGPMGF HIEYPRVVQV PDSPLAFVRV LQQNVNPEQQ LVLCVLPSDQ KDCYDSVKKF VSLEQPIPSQ CVLARTLSKQ RMMMSVATKM ALQIACKLGG ELWAVEIPLK SLMVVGIDVN KDAVAKGTSV VGFVASTNAS ITRWYSHCVI QKAGTMTADC LKVCMEGAIN KWQTCNGELP ARVIVYRDGI GNGQLRMVVD YEVPQLLSVL NECSGGFRPK LSVVIVRKQT LCRFFTEANR NLQNPPVGTV IDTEATRPEW YDFFLISQNA RQGSVNPTYY NVIYDDNGLK PDHMQRLTYK LCHLYFNWTG LIRVPAPCQY ASKLTFLVGQ SIHREPSLEL ADKLYYL //