ID   A0A7Z9E6A0_BACIU        Unreviewed;       260 AA.
AC   A0A7Z9E6A0;
DT   02-JUN-2021, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 1.
DT   03-MAY-2023, entry version 8.
DE   SubName: Full=Glyoxal reductase {ECO:0000313|EMBL:AMR64651.1};
GN   ORFNames=A1D11_03060 {ECO:0000313|EMBL:AMR64651.1};
OS   Bacillus subtilis subsp. globigii.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1496303 {ECO:0000313|EMBL:AMR64651.1, ECO:0000313|Proteomes:UP000075228};
RN   [1] {ECO:0000313|EMBL:AMR64651.1, ECO:0000313|Proteomes:UP000075228}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49760 {ECO:0000313|EMBL:AMR64651.1,
RC   ECO:0000313|Proteomes:UP000075228};
RX   PubMed=27231364;
RA   Morgan R.D.;
RT   "Complete Genome Sequence and Methylome Analysis of Bacillus globigii ATCC
RT   49760.";
RL   Genome Announc. 4:0-0(2016).
RN   [2] {ECO:0000313|Proteomes:UP000075228}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49760 {ECO:0000313|Proteomes:UP000075228};
RA   Morgan R.D.;
RT   "Complete Genome Sequence and Methylome Analysis of Bacillus globigii ATCC
RT   49760.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP014840; AMR64651.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A7Z9E6A0; -.
DR   Proteomes; UP000075228; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19157; AKR_AKR5G1-3; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR044500; AKR5G.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
FT   DOMAIN          14..246
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        38
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         96
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            63
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   260 AA;  29860 MW;  1C51814E3FD51FB3 CRC64;
     MPRFGLGVFK VENGSEATES VKAAIKNGYR SIDTAAIYKN EEGVGAGIKE SGVARDELFI
     TSKVWNEDQG YETTLAAFEK SLERLELDYL DLYLIHWPGK DKYKDTWRAL EKLYKDGKVR
     AIGVSNFQVH HLEELLKDAE IKPMVNQVEF HPCLTQVELR EYCKKQGIQV EAWSPLMQGQ
     LLDNEVLKQI AEKHNKSVAQ VILRWDLQQD VITIPKSIKE HRIIENADIF DFELSQEDIE
     KINALNKDER VGPNPDELLF
//