ID A0A7U8PV38_BRUPB Unreviewed; 325 AA. AC A0A7U8PV38; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 19-JAN-2022, entry version 3. DE RecName: Full=Ubiquinone biosynthesis protein UbiU {ECO:0000256|HAMAP-Rule:MF_02232}; GN Name=ubiU {ECO:0000256|HAMAP-Rule:MF_02232}; GN ORFNames=BAHG_02245 {ECO:0000313|EMBL:EEY01869.1}; OS Brucella pinnipedialis (strain NCTC 12890 / BCCN 94-73 / B2/94). OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales; OC Brucellaceae; Brucella/Ochrobactrum group; Brucella. OX NCBI_TaxID=520461 {ECO:0000313|EMBL:EEY01869.1}; RN [1] {ECO:0000313|EMBL:EEY01869.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B2/94 {ECO:0000313|EMBL:EEY01869.1}; RG The Broad Institute Genome Sequencing Platform; RA Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., RA White J., Yandava C., Whatmore A.M., Perrett L.L., O'Callaghan D., RA Nusbaum C., Galagan J., Birren B.; RT "The Genome Sequence of Brucella pinnipedialis B2/94."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for O(2)-independent ubiquinone (coenzyme Q) CC biosynthesis. Together with UbiV, is essential for the C6-hydroxylation CC reaction in the oxygen-independent ubiquinone biosynthesis pathway. CC {ECO:0000256|HAMAP-Rule:MF_02232}. CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|HAMAP-Rule:MF_02232}; CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_02232}. CC -!- SUBUNIT: Forms an heterodimer with UbiV. {ECO:0000256|HAMAP- CC Rule:MF_02232}. CC -!- SIMILARITY: Belongs to the peptidase U32 family. UbiU subfamily. CC {ECO:0000256|HAMAP-Rule:MF_02232}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS999851; EEY01869.1; -; Genomic_DNA. DR RefSeq; WP_002966295.1; NZ_DS999851.1. DR GeneID; 3827869; -. DR KEGG; bpp:BPI_II287; -. DR UniPathway; UPA00232; -. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule. DR HAMAP; MF_02232; UbiU; 1. DR InterPro; IPR001539; Peptidase_U32. DR InterPro; IPR043692; UbiU. DR Pfam; PF01136; Peptidase_U32; 1. PE 3: Inferred from homology; KW 4Fe-4S {ECO:0000256|HAMAP-Rule:MF_02232}; KW Iron {ECO:0000256|HAMAP-Rule:MF_02232}; KW Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_02232}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_02232}; KW Ubiquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_02232}. FT METAL 169 FT /note="Iron-sulfur (4Fe-4S)" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02232" FT METAL 176 FT /note="Iron-sulfur (4Fe-4S)" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02232" FT METAL 193 FT /note="Iron-sulfur (4Fe-4S)" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02232" FT METAL 232 FT /note="Iron-sulfur (4Fe-4S)" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02232" SQ SEQUENCE 325 AA; 35243 MW; F8058AD8AE34C4C0 CRC64; MELICPAGTP SALREAVQAG ADAVYCGFRD ETNARNFPGL NFSRDELRDA IGFAHARNCQ VFVAINTFMR AGDEHIWYKA VDDAAALGAD AVILADFGLM AYTAERHPNQ RLHVSVQASA SNADAISFLI DAFKAKRVVL PRVLTIADIA KLGRKIPCEM EVFVFGGLCV MAEGRCSLSS YATGKSPNMN GVCSPASHVR YRHDGSELVS ELGDYTINRF PAGEAAGYPT LCKGRFNIGD EEGYAFEDPV SLDVMDHIDE LRAAGVSALK IEGRQRGKAY VAEVVSTLRQ TLAAGPEKRA ALLSRLRALS EGQQTTSGAY EKRWR //