ID A0A7U3TGT9_BOVIN Unreviewed; 152 AA. AC A0A7U3TGT9; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 29-SEP-2021, entry version 2. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369}; DE EC=7.1.1.9 {ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; GN Name=COX1 {ECO:0000313|EMBL:QQO99923.1}; OS Bos taurus (Bovine). OG Mitochondrion {ECO:0000313|EMBL:QQO99923.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:QQO99923.1}; RN [1] {ECO:0000313|EMBL:QQO99923.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=103_LCO1490_F01_16.ab1 {ECO:0000313|EMBL:QQO99930.1}, RC 25_LCO1490_F02_17.ab1 {ECO:0000313|EMBL:QQO99924.1}, RC 34_LCO1490_E09_15.ab1 {ECO:0000313|EMBL:QQO99925.1}, RC 35_LCO1490_F09_18.ab1 {ECO:0000313|EMBL:QQO99926.1}, RC 39_LCO1490_B10_04.ab1 {ECO:0000313|EMBL:QQO99927.1}, RC 45_LCO1490_H10_22.ab1 {ECO:0000313|EMBL:QQO99928.1}, RC 4_LCO1490_C07_07.ab1 {ECO:0000313|EMBL:QQO99921.1}, RC 5_LCO1490_D07_10.ab1 {ECO:0000313|EMBL:QQO99922.1}, RC 6_LCO1490_E07_13.ab1 {ECO:0000313|EMBL:QQO99923.1}, and RC 87_LCO1490_G11_20.ab1 {ECO:0000313|EMBL:QQO99929.1}; RA Naicker A.E., Zishiri O.T.; RT "Detection of species substitution in processed meat products from RT ethekwini, kwazulu-natal, South Africa."; RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the CC mitochondrial electron transport chain which drives oxidative CC phosphorylation. The respiratory chain contains 3 multisubunit CC complexes succinate dehydrogenase (complex II, CII), ubiquinol- CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to CC transfer electrons derived from NADH and succinate to molecular oxygen, CC creating an electrochemical gradient over the inner membrane that CC drives transmembrane transport and the ATP synthase. Cytochrome c CC oxidase is the component of the respiratory chain that catalyzes the CC reduction of oxygen to water. Electrons originating from reduced CC cytochrome c in the intermembrane space (IMS) are transferred via the CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 CC to the active site in subunit 1, a binuclear center (BNC) formed by CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 CC water molecules using 4 electrons from cytochrome c in the IMS and 4 CC protons from the mitochondrial matrix. {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 [Fe(II)cytochrome c] + 8 H(+)(in) + O2 = 4 CC [Fe(III)cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=7.1.1.9; CC Evidence={ECO:0000256|RuleBase:RU000369}; CC -!- COFACTOR: CC Name=Cu cation; Xref=ChEBI:CHEBI:23378; CC Evidence={ECO:0000256|ARBA:ARBA00001935}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971}; CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|ARBA:ARBA00004673, ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|ARBA:ARBA00009578, ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MW475447; QQO99921.1; -; Genomic_DNA. DR EMBL; MW475448; QQO99922.1; -; Genomic_DNA. DR EMBL; MW475449; QQO99923.1; -; Genomic_DNA. DR EMBL; MW475450; QQO99924.1; -; Genomic_DNA. DR EMBL; MW475451; QQO99925.1; -; Genomic_DNA. DR EMBL; MW475452; QQO99926.1; -; Genomic_DNA. DR EMBL; MW475453; QQO99927.1; -; Genomic_DNA. DR EMBL; MW475454; QQO99928.1; -; Genomic_DNA. DR EMBL; MW475455; QQO99929.1; -; Genomic_DNA. DR EMBL; MW475456; QQO99930.1; -; Genomic_DNA. DR UniPathway; UPA00705; -. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|ARBA:ARBA00023008, ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|ARBA:ARBA00022982, KW ECO:0000256|RuleBase:RU000369}; Heme {ECO:0000256|RuleBase:RU000369}; KW Iron {ECO:0000256|RuleBase:RU000369}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842}; KW Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU000369}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660, KW ECO:0000256|RuleBase:RU000369}; Sodium {ECO:0000256|ARBA:ARBA00023053}; KW Translocase {ECO:0000256|ARBA:ARBA00022967}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000369}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 6..30 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 51..75 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 95..118 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 130..150 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..152 FT /note="COX1" FT /evidence="ECO:0000259|PROSITE:PS50855" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QQO99923.1" FT NON_TER 152 FT /evidence="ECO:0000313|EMBL:QQO99923.1" SQ SEQUENCE 152 AA; 16243 MW; 994137416FA558F1 CRC64; YNVVVTAHAF VMIFFMVMPI MIGGFGNWLV PLMIGAPDMA FPRMNNMSFW LLPPSFLLLL ASSMVEAGAG TGWTVYPPLA GNLAHAGASV DLTIFSLHLA GVSSILGAIN FITTIINMKP PAMSQYQTPL FVWSVMITAV LLLLSLPVLA AG //