ID A0A7U0L6G7_9SAUR Unreviewed; 211 AA. AC A0A7U0L6G7; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 27-MAR-2024, entry version 11. DE SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:QQX07544.1}; DE Flags: Fragment; GN Name=BMP2 {ECO:0000313|EMBL:QQX07544.1}; OS Pelusios castanoides (Yellowbelly mud turtle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Pleurodira; Pelomedusidae; OC Pelusios. OX NCBI_TaxID=904216 {ECO:0000313|EMBL:QQX07544.1}; RN [1] {ECO:0000313|EMBL:QQX07544.1} RP NUCLEOTIDE SEQUENCE. RA Thomson R.C., Spinks P.Q., Shaffer H.B.; RT "A global phylogeny of turtles reveals a burst of climate-associated RT diversification on continental margins."; RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the TGF-beta family. CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MT959702; QQX07541.1; -; Genomic_DNA. DR EMBL; MT959705; QQX07544.1; -; Genomic_DNA. DR EMBL; MT959706; QQX07545.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7U0L6G7; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW. DR Gene3D; 2.60.120.970; -; 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR001839; TGF-b_C. DR InterPro; IPR001111; TGF-b_propeptide. DR InterPro; IPR015615; TGF-beta-rel. DR InterPro; IPR017948; TGFb_CS. DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1. DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1. DR Pfam; PF00019; TGF_beta; 1. DR Pfam; PF00688; TGFb_propeptide; 1. DR PRINTS; PR00669; INHIBINA. DR SMART; SM00204; TGFB; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00250; TGF_BETA_1; 1. DR PROSITE; PS51362; TGF_BETA_2; 1. PE 3: Inferred from homology; KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188}; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Differentiation {ECO:0000256|ARBA:ARBA00022782}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030, KW ECO:0000256|RuleBase:RU000354}; KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}. FT DOMAIN 102..211 FT /note="TGF-beta family profile" FT /evidence="ECO:0000259|PROSITE:PS51362" FT REGION 93..118 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 98..118 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QQX07544.1" FT NON_TER 211 FT /evidence="ECO:0000313|EMBL:QQX07544.1" SQ SEQUENCE 211 AA; 24225 MW; 01F6137499047B0C CRC64; KPATTSSKDP AARLLDTRLV HQNASKWESF DVTPAVMRWI AHRQPNHGFV VEVAHLDNES RVSKRHVRIS RSLHQDEDSW SQLRPLLVTF SHDGKGHPLH KREKRQAKHK QRKRHKSSCK RHPLYVDFND VGWNDWIVAP PGYGAFYCHG ECPFPLADHL NTTNHAIVQT LVNSVNSKIP KACCVPTELS AISMLYLDEN EKVVLKNYQD M //