ID A0A7U0L5P9_9SAUR Unreviewed; 232 AA. AC A0A7U0L5P9; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 29-SEP-2021, entry version 2. DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086}; DE Short=BDNF {ECO:0000256|RuleBase:RU364086}; DE Flags: Fragment; GN Name=BDNF {ECO:0000313|EMBL:QQX07139.1}; OS Acanthochelys spixii (black spine-necked swamp turtle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Pleurodira; Chelidae; OC Acanthochelys. OX NCBI_TaxID=241403 {ECO:0000313|EMBL:QQX07139.1}; RN [1] {ECO:0000313|EMBL:QQX07139.1} RP NUCLEOTIDE SEQUENCE. RA Thomson R.C., Spinks P.Q., Shaffer H.B.; RT "A global phylogeny of turtles reveals a burst of climate-associated RT diversification on continental margins."; RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Promotes the survival of neuronal populations that are all CC located either in the central nervous system or directly connected to CC it. {ECO:0000256|RuleBase:RU364086}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MT959300; QQX07139.1; -; Genomic_DNA. DR EMBL; MT959301; QQX07140.1; -; Genomic_DNA. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589; PTHR11589; 1. DR PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. PE 3: Inferred from homology; KW Growth factor {ECO:0000256|RuleBase:RU364086}. FT DOMAIN 123..230 FT /note="NGF" FT /evidence="ECO:0000259|SMART:SM00140" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QQX07139.1" FT NON_TER 232 FT /evidence="ECO:0000313|EMBL:QQX07139.1" SQ SEQUENCE 232 AA; 26060 MW; 3B6F37AF60B16381 CRC64; ISYFSCMKAA PMKEASIRGP GSLAYPGLRT HGTLESLSGP NTGSRGLTSL ADTFEHVIEE LLDEEQDVQP SEENKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA NMSMRVRRHS DPARRGELSV CDSTSEWVTA AEKKTAVDMS GATVTVLEKV PVLKGQLKQY FYETKCNPKG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DNKKRVGWRF IRIDTSCVCT LT //