ID A0A7U0L5P9_9SAUR Unreviewed; 232 AA. AC A0A7U0L5P9; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 27-NOV-2024, entry version 10. DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086}; DE Short=BDNF {ECO:0000256|RuleBase:RU364086}; DE Flags: Fragment; GN Name=BDNF {ECO:0000313|EMBL:QQX07139.1}; OS Acanthochelys spixii (black spine-necked swamp turtle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Pleurodira; Chelidae; OC Acanthochelys. OX NCBI_TaxID=241403 {ECO:0000313|EMBL:QQX07139.1}; RN [1] {ECO:0000313|EMBL:QQX07139.1} RP NUCLEOTIDE SEQUENCE. RA Thomson R.C., Spinks P.Q., Shaffer H.B.; RT "A global phylogeny of turtles reveals a burst of climate-associated RT diversification on continental margins."; RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Promotes the survival of neuronal populations that are all CC located either in the central nervous system or directly connected to CC it. {ECO:0000256|RuleBase:RU364086}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MT959300; QQX07139.1; -; Genomic_DNA. DR EMBL; MT959301; QQX07140.1; -; Genomic_DNA. DR AlphaFoldDB; A0A7U0L5P9; -. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0008021; C:synaptic vesicle; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005163; F:nerve growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR GO; GO:0007613; P:memory; IEA:TreeGrafter. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:0021675; P:nerve development; IEA:TreeGrafter. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IEA:TreeGrafter. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter. DR GO; GO:0007422; P:peripheral nervous system development; IEA:TreeGrafter. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:TreeGrafter. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:TreeGrafter. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:TreeGrafter. DR FunFam; 2.10.90.10:FF:000002; Brain-derived neurotrophic factor; 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030, KW ECO:0000256|RuleBase:RU364086}. FT DOMAIN 123..230 FT /note="Nerve growth factor-related" FT /evidence="ECO:0000259|SMART:SM00140" FT DISULFID 131..198 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT DISULFID 176..227 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT DISULFID 186..229 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QQX07139.1" FT NON_TER 232 FT /evidence="ECO:0000313|EMBL:QQX07139.1" SQ SEQUENCE 232 AA; 26060 MW; 3B6F37AF60B16381 CRC64; ISYFSCMKAA PMKEASIRGP GSLAYPGLRT HGTLESLSGP NTGSRGLTSL ADTFEHVIEE LLDEEQDVQP SEENKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA NMSMRVRRHS DPARRGELSV CDSTSEWVTA AEKKTAVDMS GATVTVLEKV PVLKGQLKQY FYETKCNPKG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DNKKRVGWRF IRIDTSCVCT LT //