ID A0A7T0Q407_MOUSE Unreviewed; 87 AA. AC A0A7T0Q407; DT 02-JUN-2021, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 1. DT 12-OCT-2022, entry version 5. DE RecName: Full=Vitamin-K-epoxide reductase (warfarin-sensitive) {ECO:0000256|ARBA:ARBA00012278}; DE EC=1.17.4.4 {ECO:0000256|ARBA:ARBA00012278}; DE Flags: Fragment; GN Name=Vkorc1 {ECO:0000313|EMBL:QPL12598.1}; OS Mus musculus domesticus (western European house mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10092 {ECO:0000313|EMBL:QPL12598.1}; RN [1] {ECO:0000313|EMBL:QPL12598.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=32970676; RA Duncan B.J.M.L., Koenders A., Burnham Q., Lohr M.T.; RT "Mus musculus populations in Western Australia lack VKORC1 mutations RT conferring resistance to first generation anticoagulant rodenticides: RT Implications for conservation and biosecurity."; RL PLoS ONE 15:0-e0236234(2020). CC -!- CATALYTIC ACTIVITY: CC Reaction=[protein]-disulfide + H2O + phylloquinone = 2,3- CC epoxyphylloquinone + [protein]-dithiol; Xref=Rhea:RHEA:13817, CC Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15759, ChEBI:CHEBI:18067, ChEBI:CHEBI:29950, CC ChEBI:CHEBI:50058; EC=1.17.4.4; CC Evidence={ECO:0000256|ARBA:ARBA00000266}; CC -!- CATALYTIC ACTIVITY: CC Reaction=[protein]-disulfide + phylloquinol = [protein]-dithiol + CC phylloquinone; Xref=Rhea:RHEA:57744, Rhea:RHEA-COMP:10593, Rhea:RHEA- CC COMP:10594, ChEBI:CHEBI:18067, ChEBI:CHEBI:28433, ChEBI:CHEBI:29950, CC ChEBI:CHEBI:50058; EC=1.17.4.4; CC Evidence={ECO:0000256|ARBA:ARBA00001488}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the VKOR family. CC {ECO:0000256|ARBA:ARBA00006214}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MT956883; QPL12598.1; -; Genomic_DNA. DR EMBL; MT956907; QPL12622.1; -; Genomic_DNA. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016900; F:oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor; IEA:UniProt. DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW. DR GO; GO:0047057; F:vitamin-K-epoxide reductase (warfarin-sensitive) activity; IEA:InterPro. DR GO; GO:0042373; P:vitamin K metabolic process; IEA:InterPro. DR CDD; cd12917; VKOR_euk; 1. DR Gene3D; 1.20.1440.130; -; 1. DR InterPro; IPR012932; VKOR. DR InterPro; IPR038354; VKOR_sf. DR InterPro; IPR042406; VKORC1/VKORC1L1. DR PANTHER; PTHR14519; PTHR14519; 1. DR Pfam; PF07884; VKOR; 1. DR SMART; SM00756; VKc; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Quinone {ECO:0000256|ARBA:ARBA00022719}; KW Redox-active center {ECO:0000256|ARBA:ARBA00023284}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..87 FT /note="Vitamin-K-epoxide reductase (warfarin-sensitive)" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5033598811" FT DOMAIN 1..87 FT /note="VKc" FT /evidence="ECO:0000259|SMART:SM00756" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:QPL12598.1" FT NON_TER 87 FT /evidence="ECO:0000313|EMBL:QPL12598.1" SQ SEQUENCE 87 AA; 9432 MW; 63A8B7645F0491D6 CRC64; PGLVRLALCL AGLALSLYAL HVKAARARDE NYRALCDVGT AISCSRVFSS RWGRGFGLVE HMLGADSVLN QSNSIFGCLF YTLQLLL //